Selected research publications

Shown here are some of the recent outstanding publications which highlight significant advances made by researchers in our institute.

Nature (2019). Daza-Martin M, et al. Isomerization of BRCA1-BARD1 promotes replication fork protection. DOI: 10.1038/s41586-019-1363-4

Nature Genetics 51:151-162 (2019). Assi SA, et al. Subtype-specific regulatory network rewiring in acute myeloid leukemia. 

Cell Reports 25: 2061–2069 (2018). Bowry A, et al. BET inhibition induces HEXIM1- and RAD51-dependent conflicts between transcription and replication.

Cancer Cell 34:626-642 e628 (2018). Martinez-Soria N, et al. The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation

Cancer Cell 34:674-689 e678 (2018). de Boer B, et al. Prospective Isolation and Characterization of Genetically and Functionally Distinct AML Subclones. 

Molecular Cell 71:25-41 e26 (2018). Higgs MR, et al. Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2

Nature Communications 9:2442 (2018). Campbell KR, Yau C Uncovering pseudotemporal trajectories with covariates from single cell and bulk expression data.

Nature Communications 9:2704 (2018). Gauvrit S, et al. HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development.

Nature Communications 9:746 (2018). Ronson GE, et al. PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation.

Cell Reports 24:1496-1511 e1498 (2018). Ward C, et al. Fine-Tuning Mybl2 Is Required for Proper Mesenchymal-to-Epithelial Transition during Somatic Reprogramming.

Nature Communications 9:229 (2018). Uckelmann et al. USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A.

N Engl J Med 377:338-351 (2017). James ND, et al. Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy

Cell 168: 843 (2017). Williamson et al. UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene.

Cell Reports 21:3498-3513 (2017). Chiang K, et al. PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression

Cell Reports 19: 1654 (2017). Loke et al. RUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t(8;21) and t(3;21) AML.

Nature Cell Biology (2017) doi: 10.1038/ncb3500 Sonneville R et al. CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis.

Molecular Cell 65:900-916 (2017). Clarke TL et al.PRMT5-dependent methylation of the TIP60 coactivator RUVBL1 is a key regulator of homologous recombination.

Nature Genetics 49:537-549 (2017). Reynolds JJ et al. DONSON encodes a novel replication fork protection factor mutated in microcephalic dwarfism.

Lancet 387:1163-1177 (2016). James ND, et al. Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial

Cancer Cell 30:578 (2016). Bardella et al. Expression of Idh1R132H in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis.

Nature Genetics 48:667 (2016). Cheng et al. Five endometrial cancer risk loci identified through genome-wide association analysis.

Nature Communications 7:13087 (2016). Kotsantis P, et al. Increased global transcription activity as a mechanism of replication stress in cancer.

Nature Structural and Molecular Biology 23:647-655 (2016). Densham R, et al.  The BRCA1:BARD1 Ubiquitin ligase activity counters chromatin barriers to DNA resection.

New England Journal of Medicine 374:1444-1454 (2016). Mehanna H, et al. PET-CT Surveillance versus Neck Dissection in Advanced Head and Neck Cancer.

Nature Genetics 48:36-43 (2016). Harley ME, et al. TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism.

EMBO J  35:515-535 (2016). Bevington SL, et al. Inducible chromatin priming is associated with the establishment of immunological memory in T cells.

Developmental Cell 36:572-587 (2016). Goode et al. Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation.

Molecular Cell 59:462-477 (2015). Higgs MR, et al. BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks.

Nature Communications 6:7203 (2015). Regha K, et al. Developmental-stage-dependent transcriptional response to leukaemic oncogene expression.

Cell Reports 12:821-836 (2015). Cauchy P, et al. Chronic FLT3-ITD Signaling in Acute Myeloid Leukemia Is Connected to a Specific Chromatin Signature.

Lancet 386:9990 (2015). Kehoe et al.Primary chemotherapy versus primary surgery for newly diagnosed advanced ovarian cancer (CHORUS): an open-label, randomised, controlled, non-inferiority trial.

Nature Medicine 21:62 (2014). Davis et al. Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.

Cell 157:1037-1049 (2014). Saponaro M, et al. RECQL5 controls transcript elongation and suppresses genome instability associated with transcription stress

Cell Reports 8: 983 (2014). Lewis et al.  A Polymorphic Enhancer near GREM1 Influences Bowel Cancer Risk through Differential CDX2 and TCF7L2 Binding.

Science 346:477-481 (2014). Moreno SP, et al. Polyubiquitylation drives replisome disassembly at the termination of DNA replication.

Nature Communications 5:3756 (2014). Cazier JB, et al. Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden.

Cell Reports 8:1974-1988 (2014). Ptasinska A, et al. Identification of a Dynamic Core Transcriptional Network in t(8;21) AML that Regulates Differentiation Block and Self-Renewal.

Molecular Cell 53:645-654 (2014). Feng T, et al. Optimal translational termination requires C4 lysyl hydroxylation of eRF1.

Nature 507:381-385 (2014). Haberle V, et al. Two independent transcription initiation codes overlap on vertebrate core promoters.

Nature Genetics 45:136 (2013). Palles et al. Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.

Cell Reports 5:1302-1315 (2013). Sarkar S, et al. Impaired autophagy in the lipid-storage disorder Niemann-Pick type C1 disease.

Genome Research 23:1938-1950 (2013). Nepal C, et al. Dynamic regulation of the transcription initiation landscape at single nucleotide resolution during vertebrate embryogenesis.

EMBO Reports 14:975-983 (2013). Garvin AJ, et al. The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair.

Lancet Oncology 13:1152-1160 (2012). Foxtrot Collaborative Group/Morton D. Feasibility of preoperative chemotherapy for locally advanced, operable colon cancer: the pilot phase of a randomised controlled trial.

Molecular Cell 45:505-516 (2012). Polo SE, et al. Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair.

Cell Reports 2:270-282 (2012). Radulescu S, et al. Luminal iron levels govern intestinal tumorigenesis after Apc loss in vivo.

EMBO J 31:3918-3934 (2012). Butler LR, et al. The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response.

EMBO J 31:4318-4333 (2012). Lichtinger M, et al. RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis.

Nature Chemical Biology 8:960-962 (2012). Ge W, et al. Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans.

Journal of Clinical Oncology  36: 4524 (2012). Skowronska et al. Biallelic ATM Inactivation Significantly Reduces Survival in Patients Treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 Trial.

Journal of Clinical Oncology  36: 4477 (2012). Bartlett et al. Mammostrat As an Immunohistochemical Multigene Assay for Prediction of Early Relapse Risk in the Tamoxifen Versus Exemestane Adjuvant Multicenter Trial Pathology Study.

Lancet 377:321-331 (2011). van de Velde CJ, et al. Adjuvant tamoxifen and exemestane in early breast cancer (TEAM): a randomised phase 3 trial.

Cancer Cell 20:797-809 (2011). Drost R, et al. BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance.

Molecular Cell 43:19-32 (2011). Sarkar S, et al. Complex inhibitory effects of nitric oxide on autophagy.

Nature Genetics 43:1169-1170 (2011). Lin H, et al. Relative overexpression of X-linked genes in mouse embryonic stem cells is consistent with Ohno's hypothesis.

PNAS 107:10799-10803 (2010). Ludwig C, et al. Quantum rotor induced hyperpolarization.

Nature Cell Biology 12:963-972 (2010). Davies CC, et al. Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation.

Molecular Cell 37:492-502 (2010). Petermann E, et al. Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.

Proc Natl Acad Sci U S A 107:16090-16095 (2010). Petermann E, et al. Chk1 promotes replication fork progression by controlling replication initiation.

Lancet Neurology 9:581-591 (2010). Williams A, et al. Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson's disease (PD SURG trial): a randomised, open-label trial.

PNAS 107:12251-12256 (2010). Blackford AN, et al. Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation.