Patients and Public

Tessa Jowell brain-matrix logo

The Tessa Jowell BRAIN MATRIX is a programme of work and its principal purpose is to improve the knowledge of, and identify potential new treatments for, glioma, a type of brain tumour.

Find out more about the background and design of the study, as well as how you can get involved in the study.

About the study

Glioma brain tumours are among the most challenging of cancers to treat. The current standard treatments of surgery, chemotherapy and radiotherapy can have limited effect in terms of the survival time of the patient. They can also impact negatively on the quality of life of the patient during the illness.

Therefore, we need new improved treatments to be developed.

With the latest advances in technology for imaging (e.g. MRI scans) and the availability of improved methods for analysing tumour tissue samples, we have a better chance of developing potential alternative treatments, which may lead to better outcomes.

At the moment we usually treat all people who are diagnosed with a grade 4 glioma in the same way.  By studying the analysis of these images and tissue samples from a large number of glioma patients, we can develop a number of groupings, known as a ‘stratification’, of different types of gliomas. These may enable us to identify different treatments for different groups of patients. The new Tessa Jowell Brain Matrix study will enable us to do this, by providing a UK-wide framework for the consistent and efficient collection and analysis of images and tissue samples. 

The diagram below shows a summary of the Tessa Jowell BRAIN MATRIX Programme:

Flowchart diagram summarising the Tessa Jowell BRAIN MATRIX Platform Study. Glioma patients will have clinical information and Quality of Life collected at their local treating hospital, with this data being sent to the BRAIN MATRIX Study Office. There will also be Imaging performed at Edinburgh and Pathology performed at Oxford/Genomics England, with the results being fed back to the patient’s local treating hospital and the BRAIN MATRIX Study Office. In the future, it is hoped that it will then be possible to match patients to therapeutic trials within and outside the Tessa Jowell BRAIN MATRIX Programme.In the platform study we aim to develop the infrastructure to provide rapid and accurate molecular diagnosis and the infrastructure to deliver clinical trials of new therapies in the future.

Aims of the study

The specific aims of the study can be described as follows:

  1. To create comprehensive databanks of images and the pathology of the glioma tumours of a large number of patients being treated at UK neuro-oncology hospitals.
  2. To conduct state of the art analyses of these images and tumour tissue samples in order to allocate patients into sub-groups of glioma types.
  3. To identify if any existing approved drugs (for other cancers or illnesses) may be candidates for a clinical trial for any of the sub-groups of patients.
  4. Where no such existing drugs are available, to share data with suitable pharmaceutical companies who may have the expertise to develop appropriate drugs for a clinical trial.
  5. Where UK neuro-oncology research centres wish to initiate their own clinical trials, to enable these trials to utilise the data available from the BRAIN MATRIX.

How many participants are needed?

The study is aiming to recruit 1,000 patients from across the UK over a period of 5 years.

Who can enter the study?

As gliomas occur at all ages and their specific subtype is hard to predict before surgery, the patient population eligible for the study is broad.

The study will be open to any adult (aged over 16 years) who is newly diagnosed with a grade 2, 3 or 4 glioma and who is able to undergo a surgical procedure, including biopsy. It will also include adults with recurrent tumours, but only if the clinical team can access an appropriate sample of their original tumour for analysis.

How to get involved

If you think you would be eligible to enter the study, then you should first talk to your oncologist at your next hospital visit about how to be involved.

If you are not being treated at one of the primary recruitment centres and are interested in the study, please discuss it with your consultant. You may still be able to be involved; however, you will need to be able to travel to one of the participating centres.

Please note that the staff at the BRAIN MATRIX Study Office are not able to directly recruit you onto the study.

Which hospitals are running the study?

The study is now open to recruitment at our first centres and further centres will open in due course:

The following hospitals are able to recruit patients to the Tessa Jowell BRAIN MATRIX – Platform Study:

 

 

The following hospitals are planning to open in the future:

 

 

 

 

Liverpool

 

 

 

Patients and Public Involvement

Involving members of the public in designing and running clinical trials, and related projects, is very important. Not only does it help us ensure the best interests of patients are always at the forefront of researchers’ minds, but it provides valuable insights into patients’ experiences that help to shape our research.

Our Study Management Group benefits greatly from patient and carer representation with the involvement of Helen Bulbeck from brainstrust and Peter Buckle. They are both an integral part of the study as co-applicants. Their role has included regularly attending meetings from the outset and being involved in the development of our patient information documents and consent procedures.

Similarly, there will be patient and/or (ex) carer representatives on our Executive Oversight Committee to help bring a patient perspective to these meetings.

The BRAIN MATRIX team also undertakes public engagement activities, for example helping run a stand at the launch of the Birmingham in Action campaign.

If you are a member of the public and would like to be involved in BRAIN MATRIX please get in touch with the BRAIN MATRIX Study Office.

Documents

These documents may be helpful to patients and members of the public: