Substantial Amendment 04 Back to 'For participating sites' SA04 MHRA Cover Letter 12th February 2016 [pdf] SA04 MHRA Acceptance of Amendment Letter 24th March 2016 [pdf] DSUR MHRA Cover Letter 12th February 2016 [pdf] DSUR REC Cover Letter 12th February 2016 [pdf] Palbociclib Investigator's Brochure December 2015 [pdf] Crizotinib Summary of Product Characteristics dated 30-Nov-2015 [pdf] AZD5363 Investigator's Brochure v7, 04 Oct 2015 [pdf] MEDI4736 Investigator's Brochure v8, 01 Sep 2015 [pdf]