Genotyping and Phenotyping of Platelets (GAPP)

We are interested in recruiting the following groups of patients from collaborating centres:

1. Patients with a clinically diagnosed platelet defect (excluding known defects such as Bernard-Soulier, Glanzmann's disease and May Hegglin anomaly) regardless of their local platelet function testing results. If potential recruits have affected family members we would also be interested in recruiting the relatives.

2. Patients with inherited thrombocytopenia. If potential recruits have affected family members we would also be interested in recruiting the relatives.

3. Women presenting with heavy menstrual bleeding (HMB) with no known cause.

4. Bleeding Disorders of Unknown Cause (BDUC)

If you are interested in participating please contact us:

• Neil Morgan (Professor of Cardiovascular Genetics) - Chief Investigator
• E-mail: n.v.morgan@bham.ac.uk

We are happy to discuss potential participants on a case by case basis.

We are very grateful to the funding bodies who support our work, the British Heart Foundation, the Wellcome Trust and the NIHR Birmingham Biomedical Research Centre (BRC).

We are also grateful to the non-malignant haematology NIHR subgroup and the Lead Network service provided by Birmingham and the Black Country Comprehensive Local Research Network.

GAPP is listed on the NIHR non-malignant haematology portfolio (ID 9858) and is co-adopted into the primary care portfolio.

Useful documents

• BCSH guidelines for the laboratory investigation of heritable disorders of platelet function - Download document [pdf, 226KB]
• Review of inherited platelet disorders with guidelines for their management on behalf of the UKHCDO - Download document [pdf, 328KB]
• Standardization of definition and management for bleeding disorder of unknown cause: communication from the SSC of the ISTH

Useful websites

• British Heart Foundation
• The Wellcome Trust
• The Platelet Society
• British Society for Haemostasis and Thrombosis
• British Society for Haematology
• Funny Blood - not-for-profit organisation founded to raise awareness of a rare blood condition called Platelet Function Disorder

For enquiries please email Professor Neil Morgan - Chief Investigator of the GAPP study.