Publications

• PEPITEM, its tripeptide pharmacophores and their peptidomimetic analogues regulate the inflammatory response through parenteral and topical dosing in models of peritonitis and psoriasis. Saviano A, Apta B, Tull S, Pezhman L, Fatima A, Sevim M, Mete A, Chimen M, Schettino A, Marigliano N, McGettrick HM, Iqbal AJ, Maione F, Rainger GE.Pharmacol Res. 2025 Mar;213:107624. doi: 10.1016/j.phrs.2025.107624. Epub 2025 Jan 22.PMID: 39855372

• Therapeutic avenues in bone repair: Harnessing an anabolic osteopeptide, PEPITEM, to boost bone growth and prevent bone loss. Lewis JW, Frost K, Neag G, Wahid M, Finlay M, Northall EH, Abudu O, Kemble S, Davis ET, Powell E, Palmer C, Lu J, Rainger GE, Iqbal AJ, Chimen M, Mahmood A, Jones SW, Edwards JR, Naylor AJ, McGettrick HM.Cell Rep Med. 2024 May 21;5(5):101574. doi: 10.1016/j.xcrm.2024.101574.PMID: 38776873

• Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease. Chimen M, McGettrick HM, Apta B, Kuravi SJ, Yates CM, Kennedy A, Odedra A, Alassiri M, Harrison M, Martin A, Barone F, Nayar S, Hitchcock JR, Cunningham AF, Raza K, Filer A, Copland DA, Dick AD, Robinson J, Kalia N, Walker LSK, Buckley CD, Nash GB, Narendran P, Rainger GE.Nat Med. 2015 May;21(5):467-475. doi: 10.1038/nm.3842. Epub 2015 Apr 20.PMID: 25894827

PEPITEM relevant publications - PEPITEM and birmingham - Search Results - PubMed

• New biologic (Ab-IPL-IL-17) for IL-17-mediated diseases: identification of the bioactive sequence (nIL-17) for IL-17A/F function. Saviano A, Manosour AA, Raucci F, Merlino F, Marigliano N, Schettino A, Wahid M, Begum J, Filer A, Manning JE, Casillo GM, Piccolo M, Ferraro MG, Marzano S, Russomanno P, Bellavita R, Irace C, Amato J, Alfaifi M, Rimmer P, Iqbal T, Pieretti S, Vellecco V, Caso F, Costa L, Giacomelli R, Scarpa R, Cirino G, Bucci M, McGettrick HM, Grieco P, Iqbal AJ, Maione F.Ann Rheum Dis. 2023 Nov;82(11):1415-1428. doi: 10.1136/ard-2023-224479. Epub 2023 Aug 14.PMID: 37580108

IL-17 biologics relevant publications - Ab-IPL-IL-17™ - Search Results - PubMed

• Galectin-9: A novel promoter of atherosclerosis progression. Krautter F, Hussain MT, Zhi Z, Lezama DR, Manning JE, Brown E, Marigliano N, Raucci F, Recio C, Chimen M, Maione F, Tiwari A, McGettrick HM, Cooper D, Fisher EA, Iqbal AJ.Atherosclerosis. 2022 Dec;363:57-68. doi: 10.1016/j.atherosclerosis.2022.11.014. Epub 2022 Nov 19.PMID: 36459823

• Galectin-9 activates platelet ITAM receptors glycoprotein VI and C-type lectin-like receptor-2. Zhi Z, Jooss NJ, Sun Y, Colicchia M, Slater A, Moran LA, Cheung HYF, Di Y, Rayes J, Poulter NS, Watson SP, Iqbal AJ.J Thromb Haemost. 2022 Apr;20(4):936-950. doi: 10.1111/jth.15625. Epub 2022 Jan 6.PMID: 34936188

• Galectin-9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin-dependent manner. Iqbal AJ, Krautter F, Blacksell IA, Wright RD, Austin-Williams SN, Voisin MB, Hussain MT, Law HL, Niki T, Hirashima M, Bombardieri M, Pitzalis C, Tiwari A, Nash GB, Norling LV, Cooper D.FASEB J. 2022 Jan;36(1):e22065. doi: 10.1096/fj.202100832R.PMID: 34847625

• Spleen Tyrosine Kinase Inhibition Mitigates Hemin-Induced Thromboinflammation in an Organ-Specific Manner in Sickle Cell Mice. El-Awaisi J, Perrella G, Mayor N, Tinkova V, Cleary SJ, Grygielska B, Watson SP, Dimitrov JD, Brill A, Hassan E, Nicolson PLR, Kavanagh D, Kalia N, Rayes J. Arteriosclerosis, Thrombosis, and Vascular Biology. 2025 Aug 15. doi: 10.1161/ATVBAHA.124.322072. PMID: 40815598
• Neutrophil and NET-driven pulmonary microvascular injury following myocardial injury: attenuation by S100A8/A9 inhibition. Lezama D, Katsoulis O, Marriott E, Grygielska B, Kavanagh D, Chen CH, Jackson MM, Jenkins E, Spencer K, Abimbola E, Kiwia N, Mahida R, Pavlovic D, McGettrick HM, Naidu B, Schiopu A, Thickett DR, Scott A, Johnston SL, Rayes J, Sapey E, Singanayagam A, El-Awaisi J. bioRxiv. 2025 Sep 12. doi: 10.1101/2025.09.12.675647
• Targeting IL-36 improves age-related coronary microcirculatory dysfunction and attenuates myocardial ischemia/reperfusion injury in mice. El-Awaisi J, Kavanagh DPJ, Rink MR, Weston CJ, Drury NE, Kalia N. JCI Insight. 2022 Mar 8;7(5):e155236. doi: 10.1172/jci.insight.155236. PMID: 35113814
• Appropriation of GPIbα from platelet-derived extracellular vesicles supports monocyte recruitment in systemic inflammation. Chimen M, Evryviadou A, Box CL, Harrison MJ, Hazeldine J, Dib LH, Kuravi SJ, Payne H, Price JMJ, Kavanagh D, Iqbal AJ, Lax S, Kalia N, Brill A, Thomas SG, Belli A, Crombie N, Adams RA, Evans SA, Deckmyn H, Lord JM, Harrison P, Watson SP, Nash GB, Rainger GE.Haematologica. 2020 May;105(5):1248-1261. doi: 10.3324/haematol.2018.215145. Epub 2019 Aug 29.PMID: 31467123
• Endothelial cell-borne platelet bridges selectively recruit monocytes in human and mouse models of vascular inflammation. Kuckleburg CJ, Yates CM, Kalia N, Zhao Y, Nash GB, Watson SP, Rainger GE.Cardiovasc Res. 2011 Jul 1;91(1):134-41. doi: 10.1093/cvr/cvr040. Epub 2011 Feb 1.PMID: 21285294

• Identification of a transitional fibroblast function in very early rheumatoid arthritis. Filer A, Ward LSC, Kemble S, Davies CS, Munir H, Rogers R, Raza K, Buckley CD, Nash GB, McGettrick HM.Ann Rheum Dis. 2017 Dec;76(12):2105-2112. doi: 10.1136/annrheumdis-2017-211286. Epub 2017 Aug 28.PMID: 28847766