Publications and grants

Publications from Centre members.

2019

Blanch RJ, Bishop J, Javidi H, Murray PI. Effect of time to primary repair on final visual outcome after open globe injury. Br J Ophthalmol. 2019 doi: 10.1136/bjophthalmol-2017-311559. [Epub ahead of print] 

Thomas CN, Thompson AN, McCance E, Berry M, Logan A, Blanch RJ*, Ahmed Z. Caspase-2 mediates site-specific retinal ganglion cell death after blunt ocular injury. Invest Ophthalmol Vis Sci 2018 59(11): 4453-4462.

Pigment epithelium-derived factor mediates retinal ganglion cell neuroprotection by suppression of caspase-2. Vigneswara V, Ahmed Z. Cell Death Dis. 2019 Feb 4;10(2):102. doi: 10.1038/s41419-019-1379-6.

2018

Alves DR, Booth SP, Scavone P, Schellenberger P, Salvage J, Dedi C, Thet N, Jenkins ATA, Waters R, Ng KW, Overall ADJ, Nzakizwanayo J, Metcalfe AD and Jones BV (2018). Development of a high-throughput ex-vivo burn wound model using porcine skin, and its application to evaluate new approaches to control wound infection. Front. Cell. Infect. Microbiol. doi: 10.3389/fcimb.2018.00196

Aquaporins and their regulation after spinal cord injury. Halsey AM, Conner AC, Bill RM, Logan A, Ahmed Z. Cells. 2018 Oct 18;7(10). pii: E174. doi: 10.3390/cells7100174. Review.

Begum G, O'Neill J, Chaudhary R, Blachford K, Snead DRJ, Berry M, Scott RAH, Logan A, Blanch RJ.  Altered Decorin Biology in Proliferative Vitreoretinopathy: A Mechanistic and Cohort Study. Invest Ophthalmol Vis Sci 2018 59(12):4929-4936. 

Caspase-2 Mediates Site-Specific Retinal Ganglion Cell Death After Blunt Ocular Injury. Thomas CN, Thompson AM, McCance E, Berry M, Logan A, Blanch RJ, Ahmed Z. Invest Ophthalmol Vis Sci. 2018 Sep 4;59(11):4453-4462. doi: 10.1167/iovs.18-24045.

David Naumann, Jon Hazeldine, Jon Bishop, Mark Midwinter, Paul Harrison, Gerard Nash, and Sam Hutchings (2018) Impact of plasma viscosity on microcirculatory flow dynamics after traumatic haemorrhagic shock: a prospective observational study.  Clin Hemorheol Microcirc. doi: 10.3233/CH-180397. [Epub ahead of print]

Harrison P; Subcommittee on Platelet Physiology (2018) The use of platelets in regenerative medicine and proposal for a new classification system: guidance from the SSC of the ISTH. J Thromb Haemost. 16(9):1895-1900. doi: 10.1111/jth.14223

Hill, L.J., Moakes, R.J.A., Vareechon, C., Butt, G., Ng, A., Brock, K., Chouhan, G., Vincent, R.C., Abbondante, S., Williams, R., Barnes, N.M., Pearlman, E., Wallace, G.R., Rauz, S., Logan, A., Grover, L.M. Sustained release of decorin to the surface of the eye enables scarless corneal regeneration. Nature Regen Medicine 3, 23, 2018 (doi: 10.1038/s41536-018-0061-4).

Kuravi SJ, Harrison P, Rainger GE, Nash GB (2018) Ability of Platelet-Derived Extracellular Vesicles to Promote Neutrophil-Endothelial Cell Interactions. Inflammation. doi: 10.1007/s10753-018-0893-5 [Epub ahead of print].

Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Promote Neuroprotection in a Genetic DBA/2J Mouse Model of Glaucoma. Mead B, Ahmed Z, Tomarev S. Invest Ophthalmol Vis Sci. 2018 Nov 1;59(13):5473-5480. doi: 10.1167/iovs.18-25310.

NF-Y-dependent regulation of glutamate receptor 4 expression and cell survival in cells of the oligodendrocyte lineage. Begum G, Otsu M, Ahmed U, Ahmed Z, Stevens A, Fulton D. Glia. 2018 Sep;66(9):1896-1914. doi: 10.1002/glia.23446.

Non-viral-mediated suppression of AMIGO3 promotes disinhibited NT3-mediated regeneration of spinal cord dorsal column axons. Almutiri S, Berry M, Logan A, Ahmed Z. Sci Rep. 2018 Jul 16;8(1):10707. doi: 10.1038/s41598-018-29124-z.

Return of function after CNS axon regeneration: Lessons from injury-responsive intrinsically photosensitive and alpha retinal ganglion cells. Berry M, Ahmed Z, Logan A. Prog Retin Eye Res. 2018 Nov 17. pii: S1350-9462(18)30047-8. doi: 10.1016/j.preteyeres.2018.11.006. Review.

Rowland, T., Perry, B., Upthegrove, R., Barnes, N.M., Chatterjee, J., Marwaha, S.  Neurotrophins, cytokines and oxidative stress mediators, and mood state in bipolar disorder: systematic review and meta-analyses. Br J Psychiatry 213, 514-525, 2018.

Samantha J. Montague, Céline Delierneux, Christelle Lecut, Nathalie Layios,Robert J. Dinsdale, Natalie S. Poulter, Robert K. Andrews, Peter Hampson, Christopher M. Wearn, Christine Lee, Nathalie Maes, Jonathan Bishop, Amy Bamford, Chris Gardiner, Tariq Iqbal, Naiem Moiemen, Steve P. Watson, Cécile Oury, Elizabeth E. Gardiner, Paul Harrison (2018) Fibrin induces GPVI shedding from platelets: soluble GPVI is elevated in patients with thermal injury. Blood Advances, 2(3):240-251.

Sii F, Barry RJ, Abbott J, Blanch RJ, MacEwen CJ, Shah P. The UK Paediatric Ocular Trauma Study 2 (POTS2): demographics and mechanisms of injuries. Clin Ophthalmol. 2018 Jan 9;12:105-111. 

Sustained release of decorin to the surface of the eye enables scarless corneal regeneration. Hill LJ, Moakes RJA, Vareechon C, Butt G, Ng A, Brock K, Chouhan G, Vincent RC, Abbondante S, Williams RL, Barnes NM, Pearlman E, Wallace GR, Rauz S, Logan A, Grover LM. NPJ Regen Med. 2018 Dec 21;3:23. doi: 10.1038/s41536-018-0061-4. eCollection 2018.

TGF-β-induced IOP elevations are mediated by RhoA in the early but not the late fibrotic phase of open angle glaucoma. Hill LJ, Mead B, Thomas CN, Foale S, Feinstein E, Berry M, Blanch RJ, Ahmed Z, Logan A. Mol Vis. 2018 Oct 29;24:712-726.

Thomas CN, Thompson AN, McCance E, Berry M, Logan A, Blanch RJ*, Ahmed Z. Caspase-2 mediates site-specific retinal ganglion cell death after blunt ocular injury. Invest Ophthalmol Vis Sci 2018 59(11): 4453-4462. *Joint senior author. Pigment epithelium-derived factor mediates retinal ganglion cell neuroprotection by suppression of caspase-2. Vigneswara V, Ahmed Z. Cell Death Dis. 2019 Feb 4;10(2):102. doi: 10.1038/s41419-019-1379-6.

2017

Ahmed, R., Newman, A.S., O’Daly, J., Duffy, S., Grafton, G., Brady, C.A., Curnow, J., Barnes, N.M.*, Gordon, J*. (*Joint senior authors) Inosine Acedoben Dimepranol promotes an early and sustained increase in the natural killer cell component of circulating lymphocytes: A clinical trial supporting anti-viral indications. Int Immunopharmacology 42, 108-114, 2017.

Blanch RJ, Bishop J, Javidi H, Murray PI. Effect of time to primary repair on final visual outcome after open globe injury. Br J Ophthalmol. 2019 doi: 10.1136/bjophthalmol-2017-311559. [Epub ahead of print] 

Caspases in retinal ganglion cell death and axon regeneration. Thomas CN, Berry M, Logan A, Blanch RJ, Ahmed Z. Cell Death Discov. 2017 Jul 3;3:17032. doi: 10.1038/cddiscovery.2017.32.

Cato LD, Wearn CM, Bishop JRB, Stone MJ, Harrison P, Moiemen N. (2017)Platelet count: A predictor of sepsis and mortality in severe burns. Burns. 2017 Oct 9. pii: S0305-4179(17)30468-0.

D’Asta F, Webber M, Bishop J, Halstead F, Moiemen N, Lord J,  Harrison P (2017) The Contribution of Leucocytes to the Antimicrobial Activity of Platelet Rich Plasma Preparations: a systematic review, Platelets, Jul 6:1-12. doi: 10.1080/09537104.2017.1317731

Dinsdale RJ, Devi A, Hampson P, Wearn CM, Bamford AL, Hazeldine J, Bishop J, Ahmed S, Watson C, Lord JM, Moiemen N, Harrison P. (2017) Changes in novel haematological parameters following thermal injury, A prospective observational cohort study, Scientific Reports, 12;7(1):3211

Hazeldine J, Naumann DN, Toman E, Davies D, Bishop JRB, Su Z, Hampson P, Dinsdale RJ, Crombie N, Duggal NA, Harrison P, Belli A, Lord JM (2017) Prehospital immune responses and development of multiple organ dysfunction syndrome following traumatic injury: A prospective cohort study. PLoS Med.14(7):e1002338.

Kozielewicz, P., Alomar, H., Yusof, S., Grafton, G., Cooper, A.J., Curnow, S.J., Ironside, J.W., Pall, H., Barnes, N.M. N-glycosylation and expression in human tissues of the orphan GPR61 receptor. FEBS Open Bio. 7, 1982-1993, 2017.

Kuravi SJ, Yates CM, Foster M, Harrison P, Hazeldine J, Hampson P, Watson C, Belli A, Midwinter M, Nash GB (2017) Changes in the pattern of plasma extracellular vesicles after severe trauma. PLoS One. 12(8):e0183640

LINGO-1 and AMIGO3, potential therapeutic targets for neurological and dysmyelinating disorders? Foale S, Berry M, Logan A, Fulton D, Ahmed Z. Neural Regen Res. 2017 Aug;12(8):1247-1251. doi: 10.4103/1673-5374.213538.

Martin YH, Jubin K, Smalley S, Wong JP, Brown RA, Metcalfe AD (2017). A novel system for expansion and delivery of human keratinocytes for the treatment of severe cutaneous injuries using microcarriers and compressed collagen. J Tissue Eng Regen Med. 2017. doi: 10.1002/term.2220.

Naumann DN, Hazeldine J, Davies DJ, Bishop J, Midwinter MJ, Belli A, Harrison P, Lord JM (2017) Endotheliopathy of Trauma is an On-Scene Phenomenon, and is Associated with Multiple Organ Dysfunction Syndrome: A Prospective Observational Study. Shock. Sep 22. doi: 10.1097/SHK.0000000000000999

Naumann DN, Hazeldine J, Midwinter MJ, Hutchings SD, Harrison P. (2017) Poor microcirculatory flow dynamics are associated with endothelial cell damage and glycocalyx shedding following traumatic hemorrhagic shock. J Trauma Acute Care Surg.  doi: 10.1097/TA.0000000000001695

Sii F, Barry RJ, Abbott J, Blanch RJ, MacEwen CJ, Shah P. The UK Paediatric Ocular Trauma Study 1 (POTS1): development of a global standardized protocol for prospective data collection in pediatric ocular trauma. Clin Ophthalmol. 2017 Feb 23;11: 449–452.

Topical Delivery of Anti-VEGF Drugs to the Ocular Posterior Segment Using Cell-Penetrating Peptides. de Cogan F, Hill LJ, Lynch A, Morgan-Warren PJ, Lechner J, Berwick MR, Peacock AFA, Chen M, Scott RAH, Xu H, Logan A. Invest Ophthalmol Vis Sci. 2017 May 1;58(5):2578-2590. doi: 10.1167/iovs.16-20072.

2016

AndreetaF, Carboni L, Grafton, G, Jeggo R, Whyment AD, van den TopM, HoyerD, Spanswick D, Barnes NM.Hippocampal 5-HT7 receptors signal phosphorylation of the GluA1 subunit to facilitate AMPA receptor mediated neurotransmission in vitro and in vivo. Br J Pharmacol 173, 1438-1451, 2016.

Hampson P, Dinsdale R, Wearn CJ, Hazeldine J, Moiemen N, Lord J, Harrison P. (2016) Neutrophil dysfunction, immature granulocytes and cell-free DNA are early biomarkers of sepsis in burn injured patients: A prospective observational cohort study. Annals of Surgery. Epub ahead of print.

Joanna Sajkowska-Kozielewicz, Pawel Kozielewicz, Nicholas M. Barnes, Iwona Wawer and Katarzyna Paradowska. Antioxidant, cytotoxic and anti-proliferative activities and total polyphenol contents of the extracts of Geissospermum reticulatum bark. Oxid Med Cell Longev doi: 10.1155/2016/2573580.

Long-term neuroprotection of retinal ganglion cells by inhibiting caspase-2. Vigneswara V, Ahmed Z. Cell Death Discov. 2016 Jun 13;2:16044. doi: 10.1038/cddiscovery.2016.44. eCollection 2016.

Powell AD, Grafton G, Roberts A, Larkin S, O’Neill N, Palandri J, Barnes NM. Novel mechanism of modulation at a ligand-gated ion channel; action of Cl-indole at the 5-HT3A receptor. Br J Pharmacol 173, 3467-3479, 2016.

Prospects for mTOR-mediated functional repair after central nervous system trauma. Berry M, Ahmed Z, Morgan-Warren P, Fulton D, Logan A. Neurobiol Dis. 2016 Jan;85:99-110. doi: 10.1016/j.nbd.2015.10.002. Epub 2015 Oct 14. Review.

siRNA-Mediated Knockdown of the mTOR Inhibitor RTP801 Promotes Retinal Ganglion Cell Survival and Axon Elongation by Direct and Indirect Mechanisms. Morgan-Warren PJ, O'Neill J, de Cogan F, Spivak I, Ashush H, Kalinski H, Ahmed Z, Berry M, Feinstein E, Scott RA, Logan A. Invest Ophthalmol Vis Sci. 2016 Feb;57(2):429-43. doi: 10.1167/iovs.15-17511.

2015

Eye drop delivery of pigment epithelium-derived factor-34 promotes retinal ganglion cell neuroprotection and axon regeneration. Vigneswara V, Esmaeili M, Deer L, Berry M, Logan A, Ahmed Z. Mol Cell Neurosci. 2015 Sep;68:212-21. doi: 10.1016/j.mcn.2015.08.001.

Prospects for mTOR-mediated functional repair after central nervous system trauma. Berry M, Ahmed Z, Morgan-Warren P, Fulton D, Logan A. Neurobiol Dis. 2016 Jan;85:99-110. doi: 10.1016/j.nbd.2015.10.002. Epub 2015 Oct 14. Review.

2014/2013/2012/2011

2014

Andrews NAPapakosta MBarnes NM. Discovery of novel anxiolytic agents - The trials and tribulations of pre-clinical models of anxiety. Neurobiol Dis 61:72-78, 2014.

Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling. Vigneswara V, Akpan N, Berry M, Logan A, Troy CM, Ahmed Z. Brain. 2014 Jun;137(Pt 6):1656-75. doi: 10.1093/brain/awu037. Epub 2014 Apr 10.

Decorin blocks scarring and cystic cavitation in acute and induces scar dissolution in chronic spinal cord wounds.Ahmed Z, Bansal D, Tizzard K, Surey S, Esmaeili M, Gonzalez AM, Berry M, Logan A. Neurobiol Dis. 2014 Apr;64:163-76. doi: 10.1016/j.nbd.2013.12.008. Epub 2013 Dec 31.

Differential cavitation, angiogenesis and wound-healing responses in injured mouse and rat spinal cords. Surey S, Berry M, Logan A, Bicknell R, Ahmed Z. Neuroscience. 2014 Sep 5;275:62-80. doi: 10.1016/j.neuroscience.2014.06.003. Epub 2014 Jun 11.

Caspase-9 mediates photoreceptor death after blunt ocular trauma. Blanch RJ, Ahmed Z, Thompson AR, Akpan N, Snead DR, Berry M, Troy CM, Scott RA, Logan A. Invest Ophthalmol Vis Sci. 2014 Sep 4;55(10):6350-7. doi: 10.1167/iovs.13-13708.

Upthegrove R, Manzanares-Teson N, Barnes NM. Cytokine function in medication-naïve first episode psychosis: a systematic review and meta-analysis. Schizophrenia Res 155, 101-108, 2014.

2013

Andreetta F, Barnes NM, Wren PB, Carboni L. p38 MAP kinase activation does not stimulate serotonin transport in rat brain: Implications for sickness behaviour mechanisms. Life Sci. 19, 30-37, 2013.

AMIGO3 is an NgR1/p75 co-receptor signalling axon growth inhibition in the acute phase of adult central nervous system injury. Ahmed Z, Douglas MR, John G, Berry M, Logan A. PLoS One. 2013 Apr 16;8(4):e61878. doi: 10.1371/journal.pone.0061878.

Caspase-2 is upregulated after sciatic nerve transection and its inhibition protects dorsal root ganglion neurons from apoptosis after serum withdrawal. Vigneswara V, Berry M, Logan A, Ahmed Z. PLoS One. 2013;8(2):e57861. doi: 10.1371/journal.pone.0057861. Epub 2013 Feb 25.

Decorin blocks scarring and cystic cavitation in acute and induces scar dissolution in chronic spinal cord wounds.Ahmed Z, Bansal D, Tizzard K, Surey S, Esmaeili M, Gonzalez AM, Berry M, Logan A. Neurobiol Dis. 2014 Apr;64:163-76. doi: 10.1016/j.nbd.2013.12.008. Epub 2013 Dec 31.

Exploiting mTOR signaling: a novel translatable treatment strategy for traumatic optic neuropathy? Morgan-Warren PJ, Berry M, Ahmed Z, Scott RA, Logan A. Invest Ophthalmol Vis Sci. 2013 Oct 23;54(10):6903-16. doi: 10.1167/iovs.13-12803. Review.

Pigment epithelium-derived factor is retinal ganglion cell neuroprotective and axogenic after optic nerve crush injury. Vigneswara V, Berry M, Logan A, Ahmed Z. Invest Ophthalmol Vis Sci. 2013 Apr 12;54(4):2624-33. doi: 10.1167/iovs.13-11803.

2012

Neuroretinal cell death in a murine model of closed globe injury: pathological and functional characterization.Blanch RJ, Ahmed Z, Sik A, Snead DR, Good PA, O'Neill J, Berry M, Scott RA, Logan A. Invest Ophthalmol Vis Sci. 2012 Oct 17;53(11):7220-6. doi: 10.1167/iovs.12-9887

2011

Ocular neuroprotection by siRNA targeting caspase-2. Ahmed Z, Kalinski H, Berry M, Almasieh M, Ashush H, Slager N, Brafman A, Spivak I, Prasad N, Mett I, Shalom E, Alpert E, Di Polo A, Feinstein E, Logan A. Cell Death Dis. 2011 Jun 16;2:e173. doi: 10.1038/cddis.2011.54.

 

Active grants held by CTSR members

Grants held by Dr Zubair Ahmed

Mechanisms of retinal ganglion cell death in direct and indirect traumatic optic neuropathy. Fight for Sight. Zubair Ahmed (PI) and Richard Blanch. 

EXO-EYE - Stem cell-derived exosomes for the treatment of traumatic and degenerative eye disease. EU H2020, Marie Curie MCSA-GF. Ben Mead and Zubair Ahmed (PI). 

The role of aquaporin-4 in limiting oedema after spinal cord injury. International Spinal Research Trust (NRB PhD Studentship). Zubair Ahmed (PI) and Ann Logan. 

White matter really matters in cerebral small vessel disease: WNT signalling in the endothelial-oligodendroglial crosstalk. Birmingham-Maastricht Joint PhD studentship. Zubair Ahmed (UoB PI), Daniel Fulton, Sebastein Foulquier and Matthijis Blankesteijn. 

Repurposing DNA damage inhibitors to promote neuroprotection and functional recovery after central nervous system trauma. MRC CiC. Zubair Ahmed (PI) and Richard Tuxworth. 

Grants held by Professor Nicholas Barnes

MRC DPFS - Development of a synthetic flowable dressing that prevents corneal scarring. Ann Logan (PI), N.M. Barnes (co-I) along with others. Total value £2.727m 

Ministry of Defence (UK), ‘Identification of a suitable drug target(s) to manipulate neuronal function in the cochlear nucleus to relieve noise-induced tinnitus’, £149,000, N.M. Barnes (PI).

MRC Proximity to Discovery - A preliminary investigation of the potential benefits of delivering the anti-scarring biological agent, decorin, using Integra’s commercial dressings. N.M. Barnes (PI), £12,550.

MRC DPFS Industry Asset Sharing Scheme - Potential of P2X7 receptor antagonism to attenuate the adverse consequences of neurotrauma (PROTECT). N.M. Barnes (PI) £911,121.

MRC Psychosis immune mechanisms stratified medicine study (PIMS). N.M. Barnes (co-I). £1.75m

Celentyx Ltd Neuropharmacology studies. £337,794

Grants held by Professor Anthony Metcalf

Scar Free Foundation LIBOR Grant: 01/09/2018 (36mths): £ 971,036 Scar Free Foundation LIBOR grant: First in Human Clinical trial of a bioactive dressing designed to prevent scarring of skin burns. Co-Investigator.

Scar Free Foundation Grant: 01/09/2018 (36mths): £1,000,000 Establishing a Centre for Conflict Wound Research. Co-Applicant.

NIHR i4i:  01/03/2019 (36 mths) £1,215,609: Fluid-Gels as Resorbable Protective Dressings for Ocular Surface Disease. Co-investigator.

NC3R’s grant: 01/03/2019 (24 mths) £ 121,762: From ageing to space travel: Developing an organotypic model of skeletal tissue disuse for understanding degeneration in altered environments. Fellowship Sponsor/Supervisor

Grants held by Dr Paul Harrison

Paul Harrison. 2018. DSTL Defence Accelerator Award, Engineering of Platelet Enhanced Plasma for the treatment of traumatic bleeding and coagulopathy. £80,000

Paul Harrison. 2017 British Heart Foundation PhD studentship. Measurement of preplatelets in inherited an acquired thrombocytopenia. £110,000