Professor Georgios V. Gkoutos PhD, DIC, FRSB, FRSM

Professor Georgios V. Gkoutos

Institute of Cancer and Genomic Sciences
Associate Director of Health Data Research UK (HDR UK), Programme Director Health Data Science
Chair of Clinical Bioinformatics

Contact details

Address
Centre for Computational Biology
Haworth Building
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Professor Gkoutos holds the chair of Clinical Bioinformatics a joint appointment between the University of Birmingham Medical School and the University Hospitals Birmingham NHS Foundation Trust.

He is a Faculty Affiliate Professor Lawrence Berkeley National Laboratory,  Associate Director of MRC Health Data Research UK, Co-Director of the WCH-Birmingham Research Institute and Alan Turing Fellow.

Qualifications

  • D.I.C., Imperial College, 2002
  • PhD in Molecular and Biological Informatics, Imperial College, 2002
  • MSc in Computational Biology, University of Essex, 1999
  • BSc (Hons) in Biochemistry, University of Essex, 1998


Biography

A biochemist by training, George was initially involved in the field of Computational Biology following a MSc degree by research on correlated mutations analysis on G-Protein coupled receptors which involved modelling class A G-Protein Coupled Receptors (GPCRs) and drug design. He then proceeded to obtain a PhD in the areas of Chemoinformatics/Bioinformatics at Imperial College of London.

After the completion of his PhD, he was awarded a MRC Career Development Fellowship at MRC Harwell, Oxford. In 2005, he joined the Department of Genetics at Cambridge University and was part of various international consortia aimed at facilitating the translation of basic research findings to applications that aimed at the identification of the genetic underpinnings of disease mechanisms. In 2012, he became the head of the Bioinformatics and Computational Biology Group at Aberystwyth University, an interdisciplinary group of bioinformatics researchers, working at the interface between computing, biology and medical applications and crossing the Department of Computer Science and the Institute of Biological, Environmental and Rural Sciences (IBERS). George maintains an Aberystwyth University honorary Professorship in Bioinformatics.

In September 2015, George joined the University of Birmingham as the Chair of Clinical Bioinformatics. Professor Gkoutos splits his time between the Centre of Computational Biology, the College of Medical and Dental Sciences, the Institute of Translational Medicine and the Queen Elizabeth Hospital.

Teaching

Research

Professor Gkoutos' research background lies within the areas of clinical and biomedical informatics, health data science, computational biology, and translational research aiming at the discovery of molecular origins of human disease and the precision medicine developments of novel disease diagnostic and intervention strategies. His expertise lies in the fields of integrative systems biology, biomedical knowledge formalization, standardisation and representation, multimodal large data harmonization, interoperability and integration, comparative phenomics, Artificial Intelligence and Machine Learning, and multiomics integration and analytics.

Other activities

Fellowships

  • Fellow of the Royal Society of Medicine
  • Fellow of the Royal Society of Biology
  • Fellow of the Alan Turing Institute

Editorial Boards

  • Member of the Computers in Biology and Medicine
  • Member of the Editorial Board of Genes
  • Member of the Editorial Board of Plos ONE
  • Member of the Editorial Board of ASSAY and Drug Development Technologies
  • Member of the Editorial Board Precision Clinical Medicine Journal

National Committees

2017 -             Member of NIHR Advanced Fellowship Panel

2016 - 2017     Member of the Medical Research Council Skills Development Panel

Honorary Posts 

  • Faculty Affiliate Professor Lawrence Berkeley National Laboratory, USA 
  • Professor of Bioinformatics, University Hospitals Birmingham, NHS Foundation Trust 
  • Honorary Professor of Bioinformatics, University of Aberystwyth

Publications

Karwath A., et.al. (2021) Redefining beta-blocker response in heart failure patients with sinus rhythm and atrial fibrillation: A novel machine learning approach to clustering., Oct 16;398(10309):1427-1435

Chua W., et.al. (2021) Quantification of fibroblast growth factor 23 and N-terminal pro-B-type natriuretic peptide to identify patients with atrial fibrillation using a high-throughput platform: A validation study, Plos Medicine, Feb 3;18(2):e1003405.

Xu Y et.al.  (2021), CACONET: a novel classification framework for microbial correlation networks, Bioinformatics. 2022 Jan 4:btab879

Chapman M, (2021), Desiderata for the development of next-generation electronic health record phenotype libraries, GigascienceSep 11;10(9):giab059.

Wang J., et.al (2021), Fractal Analysis: Prognostic Value of Left Ventricular Trabecular Complexity Cardiovascular MRI in Participants with Hypertrophic Cardiomyopathy, Radiology, Jan;298(1):71-79.

Carr et al (2021), Evaluation and improvement of the National Early Warning Score (NEWS2) for COVID-19: a multi-hospital study, BMC Med, Jan 21;19(1):23.

Chua, W., et al., (2019) Data-driven discovery and validation of circulating blood-based biomarkers associated with prevalent atrial fibrillation, 2019, Eur Heart J. 7. doi: 10.1093/eurheartj/ehy815

Leighton, S, et.al. (2019), Development and validation of multivariable prediction models of remission, recovery and quality of life outcomes in people with first episode psychosis - a machine learning approach, The Lancet Digital Health., 1, 6, e261-e270

View all publications in research portal

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