Recent publications
Article
Green, C, Clarke, J, Bicknell, R & Turner, A 2021, 'Pulmonary MicroRNA changes alter angiogenesis in chronic obstructive pulmonary disease and lung cancer', Biomedicines, vol. 9, no. 7, 830. https://doi.org/10.3390/biomedicines9070830
Robinson, J, Whitworth, K, Jinks, E, Nagy, Z, Bicknell, R & Lee, S 2020, 'An evaluation of the tumour endothelial marker CLEC14A as a therapeutic target in solid tumours', Journal of Pathology: Clinical Research, vol. 6, no. 4, pp. 308-319. https://doi.org/10.1002/cjp2.176
Zhuang, X, Maione, F, Robinson, J, Bentley, M, Kaul, B, Whitworth, K, Jumbu, N, Jinks, E, Bystrom, J, Gabriele, P, Garibaldi, E, Delmastro, E, Nagy, Z, Gilham, D, Giraudo, E, Bicknell, R & Lee, S 2020, 'CAR T-cells targeting tumor endothelial marker CLEC14A inhibit tumor growth', JCI Insight, vol. 5, no. 19, e138808. https://doi.org/10.1172/jci.insight.138808
Lupino, L, Perry, T, Margielewska, S, Hollows, R, Ibrahim, M, Care, M, Allegood, J, Tooze, R, Sabbadini, R, Reynolds, G, Bicknell, R, Rudzki, Z, Lin Hock, Y, Zanetto, U, Wei, W, Simmons, W, Spiegel, S, Woodman, CBJ, Rowe, M, Vrzalikova, K & Murray, PG 2019, 'Sphingosine-1-phosphate signalling drives an angiogenic transcriptional programme in diffuse large B cell lymphoma', Leukemia, vol. 33, no. 12, pp. 2884-2897. https://doi.org/10.1038/s41375-019-0478-9
Khan, K, Naylor, A, Khan, A, Noy, P, Mambretti, M, Lodhia, P, Athwell, J, Korzystka, A, Buckley, C, Willcox, B, Mohammed, F & Bicknell, R 2017, 'Multimerin-2 is a ligand for group14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface: MMRN2 binds three group 14 family C-type lectins', Oncogene, vol. 36, pp. 6097–6108. https://doi.org/10.1038/onc.2017.214
Kershaw, RM, Roberts, D, Wragg, J, Shaaban, A, Humphreys, E, Halsall, J, Price, L, Bicknell, R, Gaston, K & Jayaraman, P 2017, 'Proline-Rich Homeodomain protein (PRH/HHEX) is a suppressor of breast tumour growth', Oncogenesis, vol. 6, no. 6, e346. https://doi.org/10.1038/oncsis.2017.42
Wragg, J, Heath, V & Bicknell, R 2017, 'Sunitinib treatment enhances metastasis of innately drug resistant breast tumors', Cancer Research, vol. 77, no. 4, pp. 1008-1020. https://doi.org/10.1158/0008-5472.CAN-16-1982
Trevino, V, Cassese, A, Nagy, Z, Zhuang, X, Herbert, J, Antzack, P, Clarke, K, Davies, N, Rahman, A, Campbell, MJ, Guindani, M, Bicknell, R, Vannucci, M & Falciani, F 2016, 'A Network Biology Approach Identifies Molecular Cross-Talk between Normal Prostate Epithelial and Prostate Carcinoma Cells', PLoS Computational Biology, vol. 12, no. 4, e1004884. https://doi.org/10.1371/journal.pcbi.1004884, https://doi.org/10.1371/journal.pcbi.1004884
Khan, KA & Bicknell, R 2016, 'Anti-angiogenic alternatives to VEGF blockade', Clinical & Experimental Metastasis, vol. 33, no. 2, pp. 197-210. https://doi.org/10.1007/s10585-015-9769-3
Ferguson, H, Wragg, J, Ward, S, Heath, V, Ismail, T & Bicknell, R 2016, 'Glutamate Receptor 2D is a novel angiogenic tumour endothelial marker in colorectal cancer', OncoTarget, vol. 7, no. 15, pp. 20440-20454. https://doi.org/10.18632/oncotarget.7812
Wragg, J, Finnity, J, Anderson, J, Ferguson, H, Porfiri, E, Bhatt, R, Murray, P, Heath, V & Bicknell, R 2016, 'MCAM and LAMA4 are highly enriched in tumor blood vessels of renal cell carcinoma and predict patient outcome', Cancer Research, vol. 76, no. 8, pp. 2314-2326. https://doi.org/10.1158/0008-5472.CAN-15-1364
Patent
Naylor, A & Bicknell, R Apr. 15 2021, Treatment of osteopenia and osteoporosis.
Lee, S & Bicknell, R Sept. 21 2017, Antibodies and related molecules and uses thereof, Patent No. WO/2017/158339 .
Lee, S, Bicknell, R, Sharpe, M & Mount, N Sept. 21 2017, Chimeric antigen receptor, Patent No. WO2017158337.
Review article
Khan, KA, McMurray, JL, Mohammed, F & Bicknell, R 2019, 'C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation', The FEBS journal, vol. 286, no. 17, pp. 3299-3332. https://doi.org/10.1111/febs.14985
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