Tr (PCA-Tr) antibody

This is another IgG specificity which reacts with the Purkinje cell cytoplasm.

Primate cerebellum: The anti-Tr antibody stains cytoplasm of Purkinje cells together with the dendrites. In the molecular layer, punctate (dotted) pattern distinguishes from Yo. The staining in the Purkinje cells is finer than that of anti-Yo antibodies.

Associated tumour: Hodgkin's disease

Neurological syndrome:
Cerebellar degeneration