His research focuses on G protein-coupled receptors, which mediate the effects of several hormones and neurotransmitters, and are the targets of at least 30% of all drugs on the market. His group has developed a number of new and innovative optical methods that allow for the investigation of GPCR signalling in living cells. The methods have allowed Professor Calebiro and his team, which is made up of biologists, chemists, physicists, engineers and computer scientists, to investigate some of the fundamental mechanisms at the basis of GPCR signalling, and clarify the pathophysiology of endocrine diseases such as hypothyroidism or Cushing’s syndrome.