Rachael Shinebaum
MPharm – Pharmacy, Aston University, 2007
PhD with Integrated Studies Research Engineer
Sponsor: EPSRC and AstraZeneca
School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom
PhD Project Background
Twin Screw Granulation: A Step Towards Continuous Processing
Within the pharmaceutical industry, a shift has been made towards continuous processing to produce granules, rather than traditional batch-wise techniques. This has proven successful in plant footprint reduction, reduced process development costs and ease of scale-up to into full production. Twin-screw granulation (TSG) is a continuous process which, in recent years, has been the subject of much research to increase knowledge in its role within solid oral dosage form manufacturing. TSG has a large number of variable process parameters, for example, screw element configuration, screw speed, liquid feed quantity and powder feed rate. Rachael’s PhD project aims to gain a deeper understanding of the TSG process to predict the characteristics and quality of the resulting granules.
Affiliations
Member of the General Pharmaceutical Council (GPhC) – 2008 onwards