Research in this area includes development of fluorescent, MRI and multi-technique molecular probes for the recognition of specific markers of disease to guide therapeutic treatment regimes, imaging blood flow, and tracking cells.
Examples of research in this area include:
- Development of fluorescent molecular probes for the detection of unusual DNA structures and for following pathways and localisations of drugs in cells
- New molecular probes based on lanthanide fluorescent markers with narrow emission peaks, long decay times, small mass and high stability against photo-bleaching
- Lanthanide molecular MRI active markers, for imaging specific tumours and macrophages and for tracing the movement and localisation of proteins in cells and tissues
- Micro-MRI contrast agents utilising oscillations between oxidative states in transition metal ion complexes for probing the chemistry of biosystems
Mini-projects and PhDs in this area have included: