Isomerization of BRCA1-BARD1 promotes replication fork protection. Daza-Martin M, Starowicz K, Jamshad M, Tye S, Ronson GE, MacKay HL, Chauhan AS, Walker AK, Stone HR, Beesley JFJ, Coles JL, Garvin AJ, Stewart GS, McCorvie TJ, Zhang X, Densham RM, Morris JR. Nature. 2019 Jul;571(7766):521-527. doi: 10.1038/s41586-019-1363-4. Epub 2019 Jul 3. PMID: 31270457
The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanisms. Garvin AJ, Walker AK, Densham RM, Chauhan AS, Stone HR, Mackay HL, Jamshad M, Starowicz K, Daza-Martin M, Ronson GE, Lanz AJ, Beesley JF, Morris JR. Genes Dev. 2019 Mar 1;33(5-6):333-347. doi: 10.1101/gad.321125.118. Epub 2019 Feb 22. PMID: 30796017
USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A. Uckelmann M, Densham RM, Baas R, Winterwerp HHK, Fish A, Sixma TK, Morris JR. Nat Commun. 2018 Jan 15;9(1):229. doi: 10.1038/s41467-017-02653-3. PMID: 29335415
Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection. Densham RM, Garvin AJ, Stone HR, Strachan J, Baldock RA, Daza-Martin M, Fletcher A, Blair-Reid S, Beesley J, Johal B, Pearl LH, Neely R, Keep NH, Watts FZ, Morris JR. Nat Struct Mol Biol. 2016 Jul;23(7):647-55. doi: 10.1038/nsmb.3236. Epub 2016 May 30. PMID: 27239795
The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair. Garvin AJ, Densham RM, Blair-Reid SA, Pratt KM, Stone RM, Weekes D, Lawrence KJ, and Morris JR. EMBO reports (2013) 14(11) 975-83. doi: 10.1038/embor.2013.141