CEDAM publications

Below is a list of the latest publications by CEDAM

Read, M., Brookes, K., Thornton, C., Fletcher, A., Nieto, H., Alshahrani, M., Khan, R., Borges de Souza, P., Zha, L., Webster, J., Alderwick, L., Campbell, M., Boelaert, K., Smith, V., & McCabe, C. (2021). Targeting non-canonical pathways as a strategy to modulate the sodium iodide symporter. Cell Chemical Biology, 2021, 1-23. https://doi.org/10.1016/j.chembiol.2021.07.016
Grech, O., Clouter, A., Mitchell, J., Alimajstorovic, Z., Ottridge, R., Yiangou, A., Roque, M., Tahrani, A., Nicholls, M., Taylor, A., Shaheen, F., Arlt, W., Lavery, G., Shapiro, K., Mollan, S., & Sinclair, A. (2021). Cognitive performance in idiopathic intracranial hypertension and relevance of intracranial pressure. Brain Communications, 3(3), [fcab202]. https://doi.org/10.1093/braincomms/fcab202
Pickford, P., Lucey, M. A., Rujan, R-M., McGlone, E. R., Bitsi, S., Ashford, F., Corrêa, I. R., Hodson, D., Tomas, A., Deganutti, G., Reynolds, C. A., Owen, B., Tan, T. M., Minnion, J., Jones, B., & Bloom, S. R. (2021). Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist. Molecular metabolism, 51, [101242]. https://doi.org/10.1016/j.molmet.2021.101242
Nasteska, D., Cuozzo, F., Viloria, K., Johnson, E., Thakker, A., Bakar, R. B., Westbrook, R., Barlow, J., Hoang, M., Joseph, J., Lavery, G., Akerman, I., Cantley, J., Hodson, L., Tennant, D., & Hodson, D. (2021). Prolyl-4-hydroxylase 3 maintains β-cell glucose metabolism during fatty acid excess in mice. JCI Insight, 6(16), [e140288]. https://doi.org/10.1172/jci.insight.140288
Yiangou, A., Mitchell, J., Nicholls, M., Chong, Y. J., Vijay, V., Wakerley, B., Lavery, G., Tahrani, A., Mollan, S., & Sinclair, A. (2021). Obstructive sleep apnoea in women with idiopathic intracranial hypertension: a substudy of the Idiopathic Intracranial Hypertension Weight randomised controlled trial (IIH:WT). Journal of Neurology. https://doi.org/10.1007/s00415-021-10700-9
Bothou, C., Sharma, A., Oo, A., Kim, B., Perge, P., Igaz, P., Ronchi, C., Shapiro, I., & Hantel, C. (2021). Novel insights into the molecular regulation of ribonucleotide reductase in adrenocortical carcinoma treatment. Cancers, 13(16), [4200]. https://doi.org/10.3390/cancers13164200
Singh, P., Adderley, N., Hazlehurst, J., Price, M., Tahrani, A., Nirantharakumar, K., & Bellary, S. (Accepted/In press). Prognostic models for predicting remission of diabetes following bariatric surgery: a systematic review and meta-analysis. Diabetes Care.
Karavitaki, N. (Accepted/In press). Consensus on diagnosis and management of Cushing’s disease: a guideline update. The Lancet Diabetes and Endocrinology.
Marzook, A., Chen, S., Pickford, P., Lucey, M. A., Wang, Y., Corrêa, I. R., Broichhagen, J., Hodson, D., Salem, V., Rutter, G. A., Tan, T. M., Bloom, S. R., Tomas, A., & Jones, B. (2021). Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1. Biochemical Pharmacology, 190, [114656]. https://doi.org/10.1016/j.bcp.2021.114656
Abid, H. A., Inoue, A., & Gorvin, C. M. (2021). Heterogeneity of G-protein activation by the calcium-sensing receptor. Journal of Molecular Endocrinology, 67(2), 41-53. https://doi.org/10.1530/JME-21-0058
Lines, K. E., Gluck, A. K., Thongjuea, S., Bountra, C., Thakker, R. V., & Gorvin, C. M. (2021). The bromodomain inhibitor JQ1+ reduces calcium-sensing receptor activity in pituitary cell-lines. Journal of Molecular Endocrinology, 67(3), 83-94. https://doi.org/10.1530/JME-21-0030
Lucey, M., Ashik, T., Marzook, A., Wang, Y., Goulding, J., Oishi, A., Broichhagen, J., Hodson, D. J., Minnion, J., Elani, Y., Jockers, R., Briddon, S. J., Bloom, S. R., Tomas, A., & Jones, B. (Accepted/In press). Acylation of the incretin peptide exendin-4 directly impacts GLP-1 receptor signalling and trafficking. Molecular Pharmacology. https://doi.org/10.1124/molpharm.121.000270
Singhal, R., Wiggins, T., Super, J., Alqahtani, A., Nadler, E. P., Ludwig, C., Tahrani, A., & Mahawar, K. (2021). 30-Day morbidity and mortality of bariatric metabolic surgery in adolescence during the COVID-19 pandemic - The GENEVA study. Pediatric Obesity, [e12832]. https://doi.org/10.1111/ijpo.12832
Olaniru, O., Cheng, J., Ast, J., Arvaniti, A., Atanes, P., Huang, GC., King, A., Jones, P., Broichhagen, J., Hodson, D., & Persaud, S. J. (2021). SNAP-tag-enabled super-resolution imaging reveals constitutive and agonist-dependent trafficking of GPR56 in pancreatic β-cells. Molecular metabolism, 53, [101285]. https://doi.org/10.1016/j.molmet.2021.101285
Elliot, L., Frew, E., Mollan, S., Mitchell, J., Yiangou, A., Alimajstorovic, Z., Ottridge, R., Wakerley, B., Thaller, M., Grech, O., Singhal, R., Tahrani, A., Harrison, M., Sinclair, A., & Aguiar, M. (2021). Cost-effectiveness of bariatric surgery versus community weight management to treat obesity-related idiopathic intracranial hypertension: evidence from a single payer health care system. Surgery for Obesity and Related Diseases, 17(7), P1310-1316. https://doi.org/10.1016/j.soard.2021.03.020
Allen, S. L., Marshall, R. N., Edwards, S. J., Lord, J. M., Lavery, G. G., & Breen, L. (2021). The effect of young and old ex vivo human serum on cellular protein synthesis and growth in an in vitro model of aging. AJP: Cell Physiology, 321(1), C26-C37. https://doi.org/10.1152/ajpcell.00093.2021
Eigenbrodt, A., Ashina, H., Khan, S., Diener, H-C., Mitsikostas, D., Sinclair, A., Pozo-Rosich, P., Martelletti, P., Ducros, A., Lanteri-Minet, M., Braschinsky, M., Sanchez Del Rio, M., Daniel, O., Ozge, A., Mammadbayli, A., Arons, M., Skorobogatykh, K., Romanenko, V., Terwindt, G., ... Ashina, M. (2021). Diagnosis and management of migraine in ten steps: consensus statement. Nature Reviews Neurology. https://doi.org/10.1038/s41582-021-00509-5
Mollan, S., Grech, O., & Sinclair, A. (2021). Headache attributed to idiopathic intracranial hypertension (IIH) and persistent post-IIH headache: a narrative review. Headache. https://doi.org/10.1111/head.14125
Mollan, S., Mitchell, J., Ottridge, R., Aguiar, M., Alimajstorovic, Z., Cartwright, D., Grech, O., Lavery, G., Westgate, C., Vijay, V., Scotton, W., Wakerley, B., Matthews, T., Ansons, A., Hickman, S., Benzimra, J., Rick, C., Singhal, R., Tahrani, A., ... Sinclair, A. (2021). Effectiveness of Bariatric Surgery vs Community Weight Management Intervention for the Treatment of Idiopathic Intracranial Hypertension: A Randomized Clinical Trial. JAMA Neurology, 78(6), 678-686. https://doi.org/10.1001/jamaneurol.2021.0659
Read, M., Brookes, K., Thornton, C., Nieto, H., Fletcher, A., Zha, L., Alderwick, L., Boelaert, K., Smith, V., & McCabe, C. (2021). Targeting non-canonical pathways as a strategy to modulate radioiodide uptake in thyroid cancer. Abstract from 27TH CONGRESS OF THE EUROPEAN ASSOCIATION FOR CANCER RESEARCH.
Mollan, S., & Sinclair, A. (2021). Outcomes measures in idiopathic intracranial hypertension. Expert Review of Neurotherapeutics. https://doi.org/10.1080/14737175.2021.1931127
Mollan, S., Chong, Y. J., Grech, O., Sinclair, A., & Wakerley, B. (2021). Current perspectives on idiopathic intracranial hypertension without papilloedema. Life, 11, [472]. https://doi.org/10.3390/life11060472
Westgate, C., Botfield, H., Alimajstorovic, Z., Yiangou, A., Walsh, M., Smith, G., Singhal, R., Mitchell, J., Grech, O., Markey, K., Hebenstreit, D., Tennant, D., Tomlinson, J., Mollan, S., Ludwig, C., Akerman, I., Lavery, G., & Sinclair, A. (2021). Systemic and adipocyte transcriptional and metabolic dysregulation in idiopathic intracranial hypertension. JCI Insight, 6(10), [e145346]. https://doi.org/10.1172/jci.insight.145346
Burden and Attitude to Resistant and Refractory (BARR) Study Group, Sacco, S., Lampl, C., Maassen Van Den Brink, A., Caponnetto, V., Braschinsky, M., Ducros, A., Little, P., Pozo-Rosich, P., Reuter, U., Ruiz De La Torre, E., Sanchez Del Rio, M., Sinclair, A., Martelletti, P., & Katsarava, Z. (2021). Burden and attitude to resistant and refractory migraine: a survey from the European Headache Federation with the endorsement of the European Migraine & Headache Alliance. The Journal of Headache and Pain, 22, [39]. https://doi.org/10.1186/s10194-021-01252-4
Gorvin, C. M. (2021). Genetic causes of neonatal and infantile hypercalcaemia. Pediatric Nephrology. https://doi.org/10.1007/s00467-021-05082-z
Foster, P. (2021). Steroid sulphatase and its inhibitors: past, present and future. Molecules, 26(10), [2852]. https://doi.org/10.3390/molecules26102852
Mollan, S., Mytton, J., Tsermoulas, G., & Sinclair, A. (2021). Idiopathic intracranial hypertension: evaluation of admissions and emergency readmissions through the hospital episode statistic dataset between 2002–2020. Life, 11(5), [417]. https://doi.org/10.3390/life11050417
Shad, B. J., Thompson, J. L., Mckendry, J., Holwerda, A. M., Elhassan, Y. S., Breen, L., van Loon, L. J. C., & Wallis, G. A. (2021). Daily myofibrillar protein synthesis rates in response to low- and high-frequency resistance exercise training in healthy, young men. International journal of sport nutrition and exercise metabolism, 31(3), 209–216. https://doi.org/10.1123/ijsnem.2020-0274
Grech, O., Mollan, S., Wakerley, B., Fulton, D., Lavery, G., & Sinclair, A. (2021). The role of metabolism in migraine pathophysiology and susceptibility. Life: Physiology and Pathology, 11(5), [415]. https://doi.org/10.3390/life11050415
Aguiar, M., Frew, E., Mollan, S., Mitchell, J., Ottridge, R., Alimajstorovic, Z., Yiangou, A., Singhal, R., Tahrani, A., & Sinclair, A. (2021). The health economic evaluation of bariatric surgery versus a community weight management intervention analysis from the idiopathic intracranial hypertension weight trial (IIH:WT). Life, 11(5), [409]. https://doi.org/10.3390/life11050409
Akerman, I., Maestro, M. A., De Franco, E., Grau, V., Flanagan, S., Garcia-Hurtado, J., Mittler, G., Ravassard, P., Piemonti, L., Ellard, S., Hattersley, A. T., & Ferrer, J. (2021). Neonatal diabetes mutations disrupt a chromatin pioneering function that activates the human insulin gene. Cell Reports, 35(2), [108981]. https://doi.org/10.1016/j.celrep.2021.108981
Powell, L., & Foster, P. (2021). Protein disulphide isomerase inhibition as a potential cancer therapeutic strategy. Cancer Medicine, 10(8), 2812-2825. https://doi.org/10.1002/cam4.3836
Antza, C., Ottridge, R., Patel, S., Slinn, G., Tearne, S., Nicholls, M., Cooper, B., Ali, A., & Tahrani, A. (2021). The impact of sleep disorders on microvascular complications in patients with type 2 diabetes (SLEEP T2D): the protocol of a cohort study and feasibility randomised control trial. Pilot and Feasibility Studies, 7(1), [80]. https://doi.org/10.1186/s40814-021-00817-z
Mueller, J. W., Vogg, N., Lightning, T. A., Weigand, I., Ronchi, C., Foster, P., & Kroiss, M. (2021). Steroid sulfation in adrenal tumors. Journal of Clinical Endocrinology and Metabolism, 2021(00), [dgab182]. https://doi.org/10.1210/clinem/dgab182
Hakami, O., Ahmed, S. K., & Karavitaki, N. (2021). Epidemiology and mortality of Cushing’s syndrome. Best practice & research. Clinical endocrinology & metabolism, [101521]. https://doi.org/10.1016/j.beem.2021.101521
Lightning, T. A., Gesteira, T. F., & Mueller, J. W. (2021). Steroid disulfates - Sulfation double trouble Molecular and Cellular Endocrinology. Molecular and Cellular Endocrinology, 524, [111161]. https://doi.org/10.1016/j.mce.2021.111161
Viloria, K., Hewison, M., & Hodson, D. (2021). Vitamin D-binding protein/GC-globulin: a novel regulator of alpha cell function and glucagon secretion. Journal of Physiology. https://doi.org/10.1113/JP280890
Read, M., Brookes, K., Thornton, C., Fletcher, A., Nieto, H., Alshahrani, M., Khan, R., Borges de Souza, P., Zha, L., Webster, J., Alderwick, L., Campbell, M., Boelaert, K., Smith, V., & McCabe, C. (2021). Targeting non-canonical pathways as a strategy to modulate the NIS symporter. SSRN. https://doi.org/10.2139/ssrn.3797274
Barnard, L., Schiffer, L., Du-Toit, R. L., Tamblyn, J., Chen, S., Africander, D., Arlt, W., Foster, P., & Storbeck, K-H. (2021). 11-oxygenated estrogens are a novel class of human estrogens but do not contribute to the circulating estrogen pool. Endocrinology, 162(3), [bqaa231]. https://doi.org/10.1210/endocr/bqaa231
Reincke, M., Albani, A., Assie, G., Bancos, I., Brue, T., Buchfelder, M., Chabre, O., Ceccato, F., Daniele, A., Detomas, M., Di Dalmazi, G., Elenkova, A., Findling, J., Grossman, A., Gomez-Sanchez, C., Heaney, A., Honegger, J., Karavitaki, N., Lacroix, A., ... Ritzel, K. (2021). Corticotroph tumor progression after bilateral adrenalectomy (Nelson’s syndrome): systematic review and expert consensus recommendations. European Journal of Endocrinology, 184(3), P1–P16. https://doi.org/10.1530/EJE-20-1088
Riley, J., Antza, C., Kempegowda, P., Subramanian, A., Chandan, J. S., Gokhale, K., Thomas, N., Sainsbury, C., Tahrani, A. A., & Nirantharakumar, K. (2021). Social deprivation and incident diabetes-related foot disease in patients with type 2 diabetes: a population-based cohort study. Diabetes Care, 44(3), 731-739. https://doi.org/10.2337/dc20-1027
Aojula, N., Ready, A., Gittoes, N., & Hassan-Smith, Z. (2021). Management of Parathyroid Disease during the COVID-19 Pandemic. Journal of Clinical Medicine, 10(5), [920]. https://doi.org/10.3390/jcm10050920
Pezhman, L., Tahrani, A., & Chimen, M. (2021). Dysregulation of Leukocyte Trafficking in Type 2 Diabetes: Mechanisms and Potential Therapeutic Avenues. Frontiers in cell and developmental biology, 9, [624184]. https://doi.org/10.3389/fcell.2021.624184
Weigand, I., Ronchi, C., Vanselow, J. T., Bathon, K., Lenz, K., Herterich, S., Schlosser, A., Kroiss, M., Fassnacht, M., Calebiro, D., & Sbiera, S. (2021). PKA Cα subunit mutation triggers caspase-dependent RIIβ subunit degradation via Ser¹¹⁴phosphorylation. Science Advances, 7(8), [eabd4176]. https://doi.org/10.1126/sciadv.abd4176
Smeuninx, B., Elhassan, Y. S., Manolopoulos, K. N., Sapey, E., Rushton, A. B., Edwards, S. J., Morgan, P. T., Philp, A., Brook, M. S., Gharahdaghi, N., Smith, K., Atherton, P. J., & Breen, L. (2021). The effect of short-term exercise prehabilitation on skeletal muscle protein synthesis and atrophy during bed rest in older men. Journal of cachexia, sarcopenia and muscle, 12(1), 52-69. https://doi.org/10.1002/jcsm.12661
Wang, J., Cooper, J., Gokhale, K., Acosta-Mena , D., Dhalla , S., Byne , N., Chandan, J. S., Anand, A., Okoth, K., Subramanian, A., Bangash, M., Jackson, T., Zemedikun, D., Taverner, T., Hanif, W., Ghosh, S., Narendran, P., Toulis, K., Tahrani, A., ... Nirantharakumar, K. (2021). Association of metformin with susceptibility to COVID-19 in people with type 2 diabetes. Journal of Clinical Endocrinology and Metabolism, [dgab067]. https://doi.org/10.1210/clinem/dgab067
Gorvin, C. M. (2021). Calcium-sensing receptor signaling - how human disease informs biology. Current Opinion in Endocrine and Metabolic Research, 16, 10-18. https://doi.org/10.1016/j.coemr.2020.06.007
Fenton, C., Martin, C., Jones, R., Croft, A., Campos, J., Naylor, A., Taylor, A., Chimen, M., Cooper, M., Lavery, G., Raza, K., & Hardy, R. (2021). Local steroid activation is a critical mediator of the anti-inflammatory actions of therapeutic glucocorticoids. Annals of the Rheumatic Diseases, 80(2), 250-260. https://doi.org/10.1136/annrheumdis-2020-218493
Subramanian, A., Idkowiak, J., Toulis, K., Thangaratinam, S., Arlt, W., & Nirantharakumar, K. (2021). Pubertal timing in boys and girls born to mothers with gestational diabetes mellitus: a systematic review. European Journal of Endocrinology, 184(1), 51–64. https://doi.org/10.1530/EJE-20-0296
Gorvin, C. M. (2021). GPCRs and Endocrinology. In Reference Module in Biomedical Sciences Elsevier. https://doi.org/10.1016/B978-0-12-820472-6.00020-7
Nasteska, D., Fine, N., Ashford, F., Cuozzo, F., Viloria, K., Smith, G., Dahir, A., Dawson, P. W. J., Lai, Y-C., Bastidas-Ponce, A., Bakhti, M., Rutter, G., Fiancette, R., Nano, R., Piemonti, L., Lickert, H., Zhou, Q., Akerman, I., & Hodson, D. (2021). PDX1^LOW MAFA^LOW β-cells contribute to islet function and insulin release. Nature Communications, 12(1), [674]. https://doi.org/10.1038/s41467-020-20632-z
Yiangou, A., Mitchell, J., Fisher, C., Edwards, J., Vijay, V., Alimajstorovic, Z., Grech, O., Lavery, G., Mollan, S., & Sinclair, A. (2021). Erenumab for headaches in idiopathic intracranial hypertension: a prospective open-label evaluation. Headache, 61(1), 157-169. https://doi.org/0.1111/head.14026
Shahzad, A. (2021). Dielectric characterization of ex vivo ovine and human adrenal glands for microwave thermal ablation applications. IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology, 2021(00), 1-9. https://doi.org/10.1109/JERM.2021.3052108
Hardy, R., Botfield, H., Markey, K., Mitchell, J., Alimajstorovic, Z., Westgate, C., Sagmeister, M., Fairclough, R., Ottridge, R., Yiangou, A., Storbeck, K-H., Taylor, A., Gilligan, L., Arlt, W., Stewart, P., Tomlinson, J., Mollan, S., Lavery, G., & Sinclair, A. (2021). 11βHSD1 inhibition with AZD4017 improves lipid profiles and lean muscle mass in Idiopathic intracranial hypertension. Journal of Clinical Endocrinology and Metabolism, 106(1), 174-187. https://doi.org/10.1210/clinem/dgaa766
Singhal, R., Tahrani, A., Ludwig, C., Mahawar, K., & GENEVA collaborators (2021). Global 30-day outcomes after bariatric surgery during the COVID-19 pandemic (GENEVA): an international cohort study. The Lancet Diabetes and Endocrinology, 9(1), [7-9]. https://doi.org/10.1016/S2213-8587(20)30375-2
Singh, P., Adderley, N., Subramanian, A., Gokhale, K., Singhal, R., Toulis, K., Bellary, S., Nirantharakumar, K., & Tahrani, A. (2021). The impact of bariatric surgery on incident microvascular complications in patients with type 2 diabetes: a matched controlled population-based retrospective cohort study. Diabetes Care, 44(1), 116-124. https://doi.org/10.2337/dc20-0571
Lempesis, I. G., Goossens, G. H., & Manolopoulos, K. N. (2021). Measurement of human abdominal and femoral intravascular adipose tissue blood flow using percutaneous Doppler ultrasound. Adipocyte, 10(1), 119-123. https://doi.org/10.1080/21623945.2021.1888471
Abbott, S., Parretti, H., Hazlehurst, J., & Tahrani, A. (2020). Socio-demographic predictors of uptake of a virtual group weight management program during the COVID-19 pandemic. Journal of Human Nutrition and Dietetics. https://doi.org/10.1111/jhn.12850
McLean, B., Wong, C. K., Campbell, J., Hodson, D., Trapp, S., & Drucker, D. (2020). Revisiting the complexity of GLP-1 action-from sites of synthesis to receptor activation. Endocrine Reviews. https://doi.org/10.1210/endrev/bnaa032
Parretti, H., Subramanian, A., Adderley, N., Abbott, S., Tahrani, A., & Nirantharakumar, K. (2020). Post-bariatric surgery nutritional follow-up in primary care: a population-based cohort study. British Journal of General Practice , 2020(00), 1-23. https://doi.org/10.3399/bjgp20X714161
Hazlehurst, J., Logue, J., Parretti, H., Abbott, S., Brown, A., Pournaras, D., & Tahrani, A. (2020). Developing integrated clinical pathways for the management of clinically severe adult obesity: A critique of NHS England policy. Current Obesity Reports, 9, 530–543. https://doi.org/10.1007/s13679-020-00416-8
Vusirikala, A., Thomas, T., Bhala, N., Tahrani, A. A., Thomas, G. N., & Nirantharakumar, K. (2020). Impact of obesity and metabolic health status in the development of non-alcoholic fatty liver disease (NAFLD): a United Kingdom population-based cohort study using the health improvement network (THIN). BMC Endocrine Disorders, 20(1), [96]. https://doi.org/10.1186/s12902-020-00582-9
Ast, J., Arvaniti, A., Fine, N. H. F., Nasteska, D., Ashford, F. B., Stamataki, Z., Koszegi, Z., Bacon, A., Jones, B. J., Lucey, M. A., Sasaki, S., Brierley, D. I., Hastoy, B., Tomas, A., D’agostino, G., Reimann, F., Lynn, F. C., Reissaus, C. A., Linnemann, A. K., ... Hodson, D. J. (2020). Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics. Nature Communications, 11(1), [467 ]. https://doi.org/10.1038/s41467-020-14309-w
Webster, J., Kempen, L., Hardy, R., & Langen, R. (2020). Inflammation and skeletal muscle wasting during cachexia. Frontiers in Physiology, 2020, [597675]. https://doi.org/10.3389/fphys.2020.597675
Mollan, S., Grech, O., Alimajstorovic, Z., Wakerley, B., & Sinclair, A. (2020). New horizons for Idiopathic intracranial hypertension. British Medical Bulletin, [ldaa034]. https://doi.org/10.1093/bmb/ldaa034
Fang, Z., Chen, S., Manchanda, Y., Bitsi, S., Pickford, P., David, A., Shchepinova, M., Corrêa, I. R., Hodson, D., Broichhagen, J., Tate, E., Reimann, F., Salem, V., Rutter, G., Tan, T. M., Bloom, S. R., Tomas, A., & Jones, B. (2020). Ligand-specific factors influencing GLP-1 receptor post-endocytic trafficking and degradation in pancreatic beta cells. International Journal of Molecular Sciences, 21(21), [8404]. https://doi.org/10.3390/ijms21218404
Graham, Y., Mahawar, K., Riera, M., Islam, O., Bhasker, A., Wilson, M., Tahrani, A., Moize, V., Leal, A., & Ha, C. (2020). Emotional resilience and bariatric surgical teams: a priority in the pandemic. Obesity surgery. https://doi.org/10.1007/s11695-020-05083-1, https://doi.org/10.1007/s11695-020-05083-1
Vijay, V., Mollan, S., Mitchell, J., Bilton, E., Alimajstorovic, Z., Markey, K., Fong, A., Walker, J., Lyons, H., Yiangou, A., Tsermoulas, G., Brock, K., & Sinclair, A. (2020). Using Optical Coherence Tomography as a Surrogate of Measurements of Intracranial Pressure in Idiopathic Intracranial Hypertension. JAMA Ophthalmology. https://doi.org/10.1001/jamaophthalmol.2020.4242
Chifu, I., Heinze, B., Fuss, C., Lang, K., Kroiss, M., Kircher, S., Ronchi, C., Altieri, B., Schirbel, A., Fassnacht, M., & Hahner, S. (Accepted/In press). Impact of the Chemokine Receptors CXCR4 and CXCR7 on Clinical Outcome in Adrenocortical Carcinoma. Frontiers in Endocrinology.
Okoth, K., Chandan, J., Marshall, T., Thangaratinam, S., Thomas, G. N., Nirantharakumar, K., & Adderley, N. (2020). The association between the reproductive health of young women and cardiovascular disease in later life: An umbrella review. BMJ, 371, 1-21. [m3502]. https://doi.org/10.1136/bmj.m3502
Majidi, F., Martino, S., Kondakci, M., Antke, C., Haase, M., Chortis, V., Arlt, W., Ronchi, C., Fassnacht, M., Laurent, C., Petit, J-M., Casasnovas, O., Habra, M., Kanji, A., Salvatori, R., Ho, A. T. N., Spyroglou, A., Beuschlein, F., Villa, D., ... Gattermann, N. (2020). Clinical spectrum of primary adrenal lymphoma: results of a multicenter cohort study. European Journal of Endocrinology, 183(4), 453–462. https://doi.org/10.1530/EJE-19-0506
Carrat, G. R., Haythorne, E., Tomas, A., Haataja, L., Müller, A., Arvan, P., Piunti, A., Cheng, K., Huang, M., Pullen, T. J., Georgiadou, E., Stylianides, T., Amirruddin, N. S., Salem, V., Distaso, W., Cakebread, A., Heesom, K. J., Lewis, P. A., Hodson, D. J., ... Rutter, G. A. (2020). The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis. Molecular metabolism, 40, [101015]. https://doi.org/10.1016/j.molmet.2020.101015
Yiangou, A., Mitchell, J., Vijay, V., Grech, O., Bilton, E., Lavery, G., Fisher, C., Edwards, J., Mollan, S., & Sinclair, A. (2020). Calcitonin gene related peptide monoclonal antibody treats headache in patients with active idiopathic intracranial hypertension. The Journal of Headache and Pain, 21(1), [116 ]. https://doi.org/10.1186/s10194-020-01182-7
Bellary, S., Tahrani, A., & Barnett, A. H. (2020). Improving management of diabetic kidney disease: will GLP-1 receptor agonists have a role? The Lancet Diabetes and Endocrinology. https://doi.org/10.1016/S2213-8587(20)30301-6
Virdee, J., Larcombe, S., Vijay, V., Sinclair, A., Dayan, M., & Mollan, S. (2020). Reviewing the recent developments in idiopathic intracranial hypertension. Ophthalmology and Therapy. https://doi.org/10.1007/s40123-020-00296-0
Fountas, A., & Karavitaki, N. (2020). Nelson’s syndrome: an update. Endocrinology and Metabolism Clinics of North America, 49(3), 413-432. https://doi.org/10.1016/j.ecl.2020.05.004
ENSAT EURINE-ACT Investigators (2020). Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE-ACT study: a prospective test validation study. The Lancet Diabetes and Endocrinology, 8(9), 773-781. https://doi.org/10.1016/S2213-8587(20)30218-7
Gittoes, N., Criseno, S., Appelman-Dijkstra, N., Bollerslev, J., Canalis, E., Rejnmark, L., & Hassan-Smith, Z. (2020). Endocrinology in the time of COVID-19: Management of calcium metabolic disorders and osteoporosis. European Journal of Endocrinology, 183(2), G57-G65. https://doi.org/10.1530/EJE-20-0385
Adderley, N., Subramanian, A., Toulis, K., Gokhale, K., Taverner, T., Hanif, W., Haroon, S., Thomas, G. N., Sainsbury, C., Tahrani, A., & Nirantharakumar, K. (2020). Obstructive sleep apnea, a risk factor for cardiovascular and microvascular disease in patients with type 2 diabetes: findings from a population-based cohort study. Diabetes Care, 43(8), 1868-1877. https://doi.org/10.2337/dc19-2116
Harrison, S. R., Jutley, G., Li, D., Sahbudin, I., Filer, A., Hewison, M., & Raza, K. (2020). Vitamin D and early rheumatoid arthritis. BMC Rheumatology, 4, [38]. https://doi.org/10.1186/s41927-020-00134-7
Grech, O., Mollan, S., Wakerley, B., Alimajstorovic, Z., Lavery, G., & Sinclair, A. (2020). Emerging themes in Idiopathic Intracranial Hypertension. Journal of Neurology. https://doi.org/10.1007/s00415-020-10090-4
Read, M. L., Brookes, K., Thornton, C. E. M., Fletcher, A., Alshahrani, M., Khan, R., Nieto, H. R., Souza, P. B. D., Webster, J. R. M., Alderwick, L. J., Boelaert, K., Smith, V. E., & McCabe, C. J. (2020, Jul 22). New mechanisms of radioiodide uptake revealed via a novel high throughput drug screening approach in thyroid cancer. https://doi.org/10.1101/2020.07.21.213967
Ntali, G., Hakami, O., Wattegama, M., Ahmed, S., & Karavitaki, N. (2020). Mortality of patients with Cushing’s disease. Experimental and Clinical Endocrinology and Diabetes. https://doi.org/10.1055/a-1197-6380
Poc, P., Gutzeit, V., Ast, J., Lee, J., Jones, B. J., D’este, E., Mathes, B., Lehmann, M., Hodson, D., Levitz, J., & Broichhagen, J. (2020). Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates. Chemical Science, 1-13. https://doi.org/10.1039/d0sc02794d
Abbott, S., Lawson, J., Singhal, R., Parretti, H., & Tahrani, A. (2020). Weight loss during medical weight management does not predict weight loss after bariatric surgery: a retrospective cohort study. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery.
Jouinot, A., Lippert, J., Fassnacht, M., De La Villeon, B., Septier, A., Neou, M., Perlemoine, K., Appenzeller, S., Sibony, M., Gaujoux, S., Dousset, B., Libe, R., Groussin, L., Ronchi, C., Assie', G., & Bertherat, J. (Accepted/In press). Intratumor heterogeneity of prognostic DNA-based molecular markers in adrenocortical carcinoma. Endocrine Connections. https://doi.org/10.1530/EC-20-0228
Prete, A., Taylor, A., Bancos, I., Smith, D., Foster, M., Kohler, S., Fazal-Sanderson, V., Komninos, J., O'Neil, D., Vas, D., Mowatt, C., Mihai, R., Fallowfield, J., Annane, D., Lord, J., Keevil, B., Wass, J., Karavitaki, N., & Arlt, W. (2020). Prevention of adrenal crisis: cortisol responses to major stress compared to stress dose hydrocortisone delivery. Journal of Clinical Endocrinology and Metabolism, 105(7), 2262–2274. https://doi.org/10.1210/clinem/dgaa133
Flint, S. W., & Tahrani, A. (2020). COVID-19 and obesity-lack of clarity, guidance, and implications for care. The Lancet Diabetes and Endocrinology, 8(6), 474-475. https://doi.org/10.1016/S2213-8587(20)30156-X
Sacco, S., Braschinsky, M., Ducros, A., Lampl, C., Little, P., Maassen Van Den Brink, A., Pozo-Rosich, P., Reuter, U., Ruiz De La Torre, E., Sanchez Del Rio, M., Sinclair, A., Katsarava, Z., & Martelletti, P. (2020). European headache federation consensus on the definition of resistant and refractory migraine : developed with the endorsement of the European Migraine & Headache Alliance (EMHA). The Journal of Headache and Pain, 21, [76]. https://doi.org/10.1186/s10194-020-01130-5
Viloria, K. M., Nasteska, D., Briant, L. J. B., Heising, S., Larner, D., Fine, N., Ashford, F., Da Silva Xavier, G., Jimenez-Gonzalez, M., Hasib, A., Cuozzo, F., Manning Fox, J., MacDonald, P., Akerman, I., Lavery, G., Flaxman, C., Morgan, N., Richardson, S., Hewison, M., & Hodson, D. (2020). Vitamin-D-binding protein contributes to the maintenance of α cell function and glucagon secretion. Cell Reports, 31(11), [107761]. https://doi.org/10.1016/j.celrep.2020.107761
Lithgow, K., Siqueira, I., Senthil, L., Chew, H., Chavda, S., Ayuk, J., Toogood, A., Gittoes, N., Matthews, T., Batra, R., Meade, S., Sanghera, P., Khan, N., Ahmed, S., Paluzzi, A., Tsermoulas, G., & Karavitaki, N. (2020). Pituitary metastases: presentation and outcomes from a pituitary center over the last decade. Pituitary, 23(3), 258–265. https://doi.org/10.1007/s11102-020-01034-2
Kemkem, Y., Nasteska, D., De Bray, A., Bargi-Souza, P., Peliciari-Garcia, R., Guillou, A., Mollard, P., Hodson, D., & Schaeffer, M. (2020). Maternal hypothyroidism in mice influences glucose metabolism in adult offspring. Diabetologia. https://doi.org/10.1007/s00125-020-05172-x
Weigand, I., Altieri, B., Lacombe, A., Basile, V., Kircher, S., Landwehr, L-S., Schreiner, J., Zerbini, M., Ronchi, C., Megerle, F., Berruti, A., Canu, L., Volante, M., Paiva, I., Della Casa, S., Sbiera, S., Fassnacht, M., Fragoso, M., Terzolo, M., & Kroiss, M. (2020). Expression of SOAT1 in adrenocortical carcinoma and response to mitotane monotherapy: an ENSAT multicenter study. The Journal of clinical endocrinology and metabolism. https://doi.org/10.1210/clinem/dgaa293
Dekkers, O., Karavitaki, N., & Pereira, A. (2020). The epidemiology of aggresssive pituitary tumors (and its challenges). Reviews in endocrine & metabolic disorders. https://doi.org/10.1007/s11154-020-09556-7
Fleseriu, M., Karavitaki, N., & Dekkers, O. (2020). Endocrinology in the time of COVID-19: management of pituitary tumours. European Journal of Endocrinology. https://doi.org/10.1530/EJE-20-0473
Hodson, D., & Rorsman, P. (2020). A variation on the theme: SGLT2 inhibition and glucagon secretion in human islets. Diabetes, 69(5), 864-866. https://doi.org/10.2337/dbi19-0035
Dharmaraj, P., Gorvin, C. M., Soni, A., Nelhans, N., Olesen, M., Boon, H., Cranston, T., Thakker, R., & Hannan, F. (2020). Neonatal hypocalcemic seizures in offspring of a mother with familial hypocalciuric hypercalcemia type 1 (FHH1). Journal of Clinical Endocrinology and Metabolism, 105(5), 1393–1400. https://doi.org/10.1210/clinem/dgaa111
Fountas, A., Lim, E. S., Drake, W. M., Powlson, A. S., Gurnell, M., Martin, N. M., Seejore, K., Murray, R. D., MacFarlane, J., Ahluwalia, R., Swords, F., Ashraf, M., Pal, A., Chong, Z., Freel, M., Balafshan, T., Purewal, T. S., Speak, R. G., Newell-Price, J., ... Karavitaki, N. (2020). Outcomes of patients with Nelson’s syndrome after primary treatment: a multicenter study from 13 UK Pituitary centers. Journal of Clinical Endocrinology and Metabolism, 105(5), 1527–1537. https://doi.org/10.1210/clinem/dgz200
Hodson, D., Pickford, P., Lucey, M. A., Fang, Z., Bitsi, S., De La Serna, B., Broichhagen, J., Minnion, J., Rutter, G., Bloom, S., Tomas, A., & Jones, B. (2020). Signalling, trafficking and glucoregulatory properties of glucagon-like peptide-1 receptor agonists exendin-4 and lixisenatide. Manuscript submitted for publication.
El-gamal, M. I., Zaraei, S., Foster, P. A., Anbar, H. S., El-gamal, R., El-awady, R., & Potter, B. V. L. (2020). A new series of aryl sulfamate derivatives: design, synthesis, and biological evaluation. Bioorganic & Medicinal Chemistry, 28(8), [115406]. https://doi.org/10.1016/j.bmc.2020.115406
Fang, Z., Chen, S., Pickford, P., Broichhagen, J., Hodson, D., Corrêa, I. R., Kumar, S., Gorlitz, F., Dunsby, C., French, P., Rutter, G., Tan, T. M., Bloom, S. R., Tomas, A., & Jones, B. (2020). The influence of peptide context on signalling and trafficking of glucagon-like peptide-1 receptor biased agonists. ACS Pharmacology & Translational Science, 3(2), 345–360. https://doi.org/10.1021/acsptsci.0c00022
Toulis, K., Nirantharakumar, K., Pourzitaki, C., Barnett, AH., & Tahrani, A. (2020). Glucokinase activators for type 2 diabetes: challenges and future developments. Drugs, 8, 467–475. https://doi.org/10.1007/s40265-020-01278-z
Welford, A. E., Lanham-New, S., Lord, J., Doyle, A., Robinson, J., Nightingale, P., Gittoes, N., & Greig, C. A. (2020). Influence of combined vitamin D3 supplementation and resistance exercise training on musculoskeletal health in older men and women (EXVITD): protocol for a randomised controlled trial. BMJ open, 10(3), [e033824]. https://doi.org/10.1136/bmjopen-2019-033824
Manojlovic-Gacic, E., Rostami, E., Karavitaki, N., & Casar-Borota, O. (2020). Histopathology of parasellar neoplasms. Neuroendocrinology. https://doi.org/10.1159/000507084
Foster, M., Taylor, A., Bishop, J., Gilligan, L., Bion, J., Lord, J., & Arlt, W. (2020). Mapping the steroid response to major trauma from injury to recovery: a prospective cohort study. Journal of Clinical Endocrinology and Metabolism, 105(3), [dgz302]. https://doi.org/10.1210/clinem/dgz302
Chortis, V., Bancos, I., Nijman, T., Gilligan, L., Taylor, A., Ronchi, C., O'Reilly, M., Schreiner, J., Asia, M., Riester, A., Perotti, P., Libe, R., Quinkler, M., Canu, L., Paiva, I., Bugalho, M. J., Kastelan, D., Dennedy, M. C., Sherlock, M., ... Arlt, W. (2020). Urine steroid metabolomics as a novel tool for detection of recurrent adrenocortical carcinoma. Journal of Clinical Endocrinology and Metabolism, 105(3), e303–e314. https://doi.org/10.1210/clinem/dgz141
Doig, C. L., Zielinska, A. E., Fletcher, R. S., Oakey, L. A., Elhassan, Y. S., Garten, A., Cartwright, D., Heising, S., Alsheri, A., Watson, D. G., Prehn, C., Adamski, J., Tennant, D. A., & Lavery, G. G. (2020). Induction of the nicotinamide riboside kinase NAD⁺ salvage pathway in a model of sarcoplasmic reticulum dysfunction. Skeletal Muscle, 10(1), [5]. https://doi.org/10.1186/s13395-019-0216-z
Gittoes, N., Lord, J., Doyle, A., Robinson, J., Nightingale, P., Greig, C., Welford, A., & Lanham-New, S. (Accepted/In press). The influence of combined vitamin D3 supplementation and resistance exercise training on musculoskeletal health in older men and women (EXVITD): protocol for a randomized controlled trial. BMJ open.
Altieri, B., Sbiera, S., Herterich, S., De Francia, S., Della Casa, S., Calabrese, A., Pontecorvi, A., Quinkler, M., Kienitz, T., Mannelli, M., Canu, L., Angelousi, A., Chortis, V., Kroiss, M., Terzolo, M., Fassnacht, M., & Ronchi, C. L. (2020). Effects of germline CYP2W1*6 and CYP2B6*6 single nucleotide polymorphisms on mitotane treatment in adrenocortical carcinoma: a multicenter ENSAT study. Cancers, 12(2), [359]. https://doi.org/10.3390/cancers12020359, https://doi.org/10.3390/cancers12020359
Tresoldi, A., Sumilo, D., Perrins, M., Toulis, K., Prete, A., Reddy, N., Wass, J., Arlt, W., & Nirantharakumar, K. (2020). Increased infection risk in Addison's disease and congenital adrenal hyperplasia: a primary care database cohort study. Journal of Clinical Endocrinology and Metabolism, 105(2), 1-2. [dgz006]. https://doi.org/10.1210/clinem/dgz006
Singh, P., Subramanian, A., Adderley, N., Gokhale, K., Shinghal, R., Bellary, S., Nirantharakumar, K., & Tahrani, A. (2020). Impact of bariatric surgery on cardiovascular outcomes and mortality: a population‐based cohort study. British Journal of Surgery. https://doi.org/10.1002/bjs.11433
Gurney, S., Ramalingam, S., Thomas, A., Sinclair, A., & Mollan, S. (2020). Exploring the current management idiopathic intracranial hypertension, and understanding the role of dural venous sinus stenting. Eye and Brain, 2020(12). https://doi.org/10.2147/EB.S193027
Markey, K., Mitchell, J., Botfield, H., Ottridge, R., Matthews, T., Krishnan, A., Woolley, R., Westgate, C., Yiangou, A., Alimajstorovic, Z., Shah, P., Rick, C., Ives, N., Taylor, A., Gilligan, L., Jenkinson, C., Arlt, W., Scotton, W., Fairclough, R. J., ... Sinclair, A. (2020). 11β-hydroxysteroid dehydrogenase type 1 inhibition in idiopathic intracranial hypertension: a double-blind randomized controlled trial. Brain Communications, 2(1), [fcz050]. https://doi.org/10.1093/braincomms/fcz050
Sinclair, A., Alimajstorovic, Z., Westgate, C., Jensen, R. H., Eftekhari, S., Mitchell, J., Vijay, V., & Mollan, S. (2020). Guide to preclinical models used to study the pathophysiology of idiopathic intracranial hypertension. Eye. https://doi.org/10.1038/s41433-019-0751-1
Fountas, A., Van Uum, S., & Karavitaki, N. (2020). Opioid-induced endocrinopathies. The Lancet Diabetes and Endocrinology, 8(1), 68-80. https://doi.org/10.1016/S2213-8587(19)30254-2
Parsons, C., Harvey, N., & Gittoes, N. (2020). Systematic screening using FRAX® leads to increased use of, and adherence to, anti-osteoporosis medications: an analysis of the UK SCOOP trial. Osteoporosis International, 31(1), 67-75. https://doi.org/10.1007/s00198-019-05142-z
Black, J. K., Whittaker, A. C., Tahrani, A. A., & Balanos, G. M. (2020). The implementation of a physical activity intervention in adults with Obstructive Sleep Apnoea over the age of 50 years: a feasibility uncontrolled clinical trial. BMC Sports Science, Medicine and Rehabilitation, 12, 46. https://doi.org/10.1186/s13102-020-00195-8
Kahal, H., Tahrani, A. A., Kyrou, I., Dimitriadis, G. K., Kimani, P. K., Barber, T. M., Nicholls, M., Ali, A., Weickert, M. O., & Randeva, H. S. (2020). The relationship between obstructive sleep apnoea and quality of life in women with polycystic ovary syndrome: a cross-sectional study. Therapeutic Advances in Endocrinology and Metabolism, 11, 2042018820906689. https://doi.org/10.1177/2042018820906689
Kahal, H., Tahrani, A. A., Kyrou, I., Dimitriadis, G. K., Kimani, P. K., Barber, T. M., Nicholls, M., Ali, A., Weickert, M. O., & Randeva, H. S. (2020). The relationship between obstructive sleep apnoea and quality of life in women with polycystic ovary syndrome: a cross-sectional study. Therapeutic Advances in Endocrinology and Metabolism, 11, 2042018820906689. https://doi.org/10.1177/2042018820906689
Viloria, K., Nasteska, D., Briant, L. J. B., Heising, S., Larner, D., Fine, N. H. F., Ashford, F. B., Xavier, G. D. S., Ramos, M. J., Fox, J. E. M., MacDonald, P. E., Akerman, I., Lavery, G. G., Flaxman, C., Morgan, N. G., Richardson, S. J., Hewison, M., & Hodson, D. J. (2019, Dec 19). Vitamin D-binding protein is required for the maintenance of α-cell function and glucagon secretion. https://doi.org/10.1101/2019.12.19.881185
Samperi, I., Lithgow, K., & Karavitaki, N. (2019). Hyperprolactinaemia. Journal of Clinical Medicine, 8(12), [2203]. https://doi.org/10.3390/jcm8122203
Grienke, U., Kaserer, T., Kirchweger, B., Lambrinidis, G., Kandel, R. T., Foster, P., Schuster, D., Mikros, E., & Rollinger, J. M. (2019). Steroid sulfatase inhibiting lanostane triterpenes – structure activity relationship and in silico insights. Bioorganic Chemistry, 95, [103495]. https://doi.org/10.1016/j.bioorg.2019.103495
Crowe, F., Thayakaran, T., Gittoes, N., Hewison, M., Thomas, G. N., Scragg, R., & Nirantharakumar, K. (2019). Non-linear associations of 25-hydroxyvitamin D concentrations with risk of cardiovascular disease and all-cause mortality: results from The Health Improvement Network (THIN) database. The Journal of Steroid Biochemistry and Molecular Biology, 195, [105480]. https://doi.org/10.1016/j.jsbmb.2019.105480
Storbeck, K-H., Schiffer, L., Baranowski, E., Chortis, V., Prete, A., Barnard, L., Gilligan, L., Taylor, A., Idkowiak, J., Arlt, W., & Shackleton, C. (2019). Steroid metabolome analysis in disorders of adrenal steroid biosynthesis and metabolism. Endocrine Reviews, 40(6), 1605-1625. https://doi.org/10.1210/er.2018-00262
Alexandraki, K. I., Kaltsas, G. A., Karavitaki, N., & Grossman, A. (2019). The medical therapy of craniopharyngiomas: the way ahead. Journal of Clinical Endocrinology and Metabolism, 104(12), 5751–5764. https://doi.org/10.1210/jc.2019-01299
Webster, J., Fenton, C., Langen, R., & Hardy, R. (2019). Exploring the interface between inflammatory and therapeutic glucocorticoid induced bone and muscle loss. International Journal of Molecular Sciences, 20(22), [5768]. https://doi.org/10.3390/ijms20225768
Moi, D., Foster, P., Rimmer, L., Jaffri, A., Deplano, A., Balboni, G., Onnis, V., & Potter, B. V. L. (2019). Synthesis and in vitro evaluation of piperazinyl-ureido sulfamates as steroid sulfatase inhibitors. European Journal of Medicinal Chemistry, 182, [111614]. https://doi.org/10.1016/j.ejmech.2019.111614
Schiffer, L., Barnard, L., Baranowski, E., Gilligan, L., Taylor, A., Arlt, W., Shackleton, C., & Storbeck, K-H. (2019). Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review. The Journal of Steroid Biochemistry and Molecular Biology, 194, [105439]. https://doi.org/10.1016/j.jsbmb.2019.105439
Lithgow, K., Batra, R., Matthews, T., & Karavitaki, N. (2019). Management of endocrine disease: visual morbidity in patients with pituitary adenoma. European Journal of Endocrinology, 181(5), R185-R197. https://doi.org/10.1530/EJE-19-0349
Torlinska, B., Nichols, L., Mohammed, M. A., McCabe, C., & Boelaert, K. (2019). Patients treated for hyperthyroidism are at increased risk of becoming obese: findings from a large prospective secondary care cohort. Thyroid, 29(10), 1380-1389. https://doi.org/10.1089/thy.2018.0731
Lippincott, M. F., León, S., Chan, Y., Fergani, C., Talbi, R., Farooqi, I. S., Jones, C. M., Arlt, W., Stewart, S. E., Cole, T. R., Terasawa, E., Hall, J. E., Shaw, N. D., Navarro, V. M., & Seminara, S. B. (2019). Hypothalamic reproductive endocrine pulse generator activity independent of neurokinin B and dynorphin signaling. Journal of Clinical Endocrinology and Metabolism, 104(10), 4304-4318. https://doi.org/10.1210/jc.2019-00146
Shad, B., Thompson, J., Holwerda, A., Stocks, B., Elhassan, Y., Philp, A., van Loon, L., & Wallis, G. (2019). One week of step reduction lowers myofibrillar protein synthesis rates in young men. Medicine and Science in Sports and Exercise, 51(10), 2125-2134. https://doi.org/10.1249/MSS.0000000000002034
Ronchi, C. (2019). cAMP/protein kinase A signalling pathway and adrenocortical adenomas. Current Opinion in Endocrine and Metabolic Research, 8, 15-21. https://doi.org/10.1016/j.coemr.2019.06.003
Thompson, R. J., Fletcher, A., Brookes, K., Nieto, H., Alshahrani, M. M., Mueller, J. W., Fine, N. H. F., Hodson, D. J., Boelaert, K., Read, M. L., Smith, V. E., & McCabe, C. J. (2019). Dimerization of the sodium/iodide symporter. Thyroid, 29(10), 1485-1498. https://doi.org/10.1089/thy.2019.0034
Lavrentaki, A., Thomas, T., Subramanian, A., Valsamakis, G., Thomas, N., Toulis, K. A., Wang, J., Daly, B., Saravanan, P., Sumilo, D., Mastorakos, G., Tahrani, A. A., & Nirantharakumar, K. (2019). Increased risk of non-alcoholic fatty liver disease in women with gestational diabetes mellitus: A population-based cohort study, systematic review and meta-analysis. Journal of Diabetes and its Complications, 33(10), 107401. https://doi.org/10.1016/j.jdiacomp.2019.06.006
Karavitaki, N., & Souteiro, P. (2019). Dopamine agonist resistant prolactinomas - any alternative medical treatment? Pituitary. https://doi.org/10.1007/s11102-019-00987-3
de Vries, F., Bruin, M., Lobatto, D. J., Dekkers, O., Schoones, J. W., van Furth, W. R., Pereira, A., Karavitaki, N., Biermasz, N. R., & Zamanipoor Najafabadi, A. H. (2019). Opioids and their endocrine effects: a systematic review and meta-analysis. The Journal of clinical endocrinology and metabolism, [dgz022]. https://doi.org/10.1210/clinem/dgz022
Hodson, D. (2019). Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta-cell dysfunction in type 2 diabetes. Diabetologia.
Thayakaran, T., Adderley, N., Sainsbury, C., Torlinska, B., Boelaert, K., Sumilo, D., Price, M., Thomas, G. N., Toulis, K., & Nirantharakumar, K. (2019). Thyroid replacement therapy, thyroid stimulating hormone concentrations, and long term health outcomes in patients with hypothyroidism: longitudinal study. BMJ, 366, [l4892]. https://doi.org/10.1136/bmj.l4892
Schiffer, L., Adaway, J. E., Arlt, W., & Keevil, B. G. (2019). A liquid chromatography-tandem mass spectrometry assay for the profiling of classical and 11-oxygenated androgens in saliva. Annals of Clinical Biochemistry, 56(5), 564-573. https://doi.org/0.1177/0004563219847498
Adderley, N., Subramanian, A., Nirantharakumar, K., Yiangou, A., Gokhale, K., Mollan, S., & Sinclair, A. (2019). Association between idiopathic intracranial hypertension and risk of cardiovascular diseases in women in the United Kingdom. JAMA Neurology, 76(9), 1088-1098. https://doi.org/10.1001/jamaneurol.2019.1812
Elhassan, Y. S., Kluckova, K., Fletcher, R. S., Schmidt, M. S., Garten, A., Doig, C. L., Cartwright, D. M., Oakey, L., Burley, C. V., Jenkinson, N., Wilson, M., Lucas, S. J. E., Akerman, I., Seabright, A., Lai, Y., Tennant, D. A., Nightingale, P., Wallis, G. A., Manolopoulos, K. N., ... Lavery, G. G. (2019). Nicotinamide riboside augments the aged human skeletal muscle NAD⁺ metabolome and induces transcriptomic and anti-inflammatory signatures. Cell Reports, 28(7), 1717-1728.e6. https://doi.org/10.1016/j.celrep.2019.07.043
Gorvin, C. M. (2019). Molecular and clinical insights from studies of calcium-sensing receptor mutations. Journal of Molecular Endocrinology, 63(2), R1-R16. https://doi.org/10.1530/JME-19-0104
Toulis, K. A., Viola, D., Gkoutos, G., Keerthy, D., Boelaert, K., & Nirantharakumar, K. (2019). Risk of incident circulatory disease in patients treated for differentiated thyroid carcinoma with no history of cardiovascular disease. Clinical Endocrinology, 91(2), 323-330. https://doi.org/10.1111/cen.13990
Fenton, C., Webster, J., Martin, C., Fareed, S., Wehmeyer, C., Mackie, H., Jones, R., Seabright, A., Lewis, J., Lai, Y-C., Goodyear, C. S., Jones, S., Cooper, M. S., Lavery, G., Langen, R., Raza, K., & Hardy, R. (2019). Therapeutic glucocorticoids prevent bone loss but drive muscle wasting when administered in chronic polyarthritis. Arthritis Research & Therapy, 21(1), [182]. https://doi.org/10.1186/s13075-019-1962-3
Tamblyn, J., Jeffery, L., Susarla, R., Lissauer, D., Coort, S. L., Munoz Garcia, A., Knoblich, K., Fletcher, A., Bulmer, JN., Kilby, M., & Hewison, M. (2019). Transcriptomic analysis of vitamin D responses in uterine and peripheral NK cells. Reproduction, 158(2), 211-221. https://doi.org/10.1530/REP-18-0509
Attard, G., Merseburger, A. S., Arlt, W., Sternberg, C. N., Feyerabend, S., Berruti, A., Joniau, S., Géczi, L., Lefresne, F., Lahaye, M., Shelby, F. N., Pissart, G., Chua, S., Jones, R. J., & Tombal, B. (2019). Assessment of the safety of glucocorticoid regimens in combination with abiraterone acetate for metastatic castration-resistant prostate cancer: a randomized, open-label phase 2 study. JAMA Oncology, 5(8), 1159-1167. https://doi.org/10.1001/jamaoncol.2019.1011
Bellary, S., Tahrani, A. A., & Barnett, A. H. (2019). IDegLira: combining efficacy, durability, and convenience? The Lancet Diabetes and Endocrinology, 7(8), 584-585. https://doi.org/10.1016/S2213-8587(19)30198-6
Grienke, U., Foster, P., Zwirchmayr, J., Tahir, A., Rollinger, J. M., & Mikros, E. (2019). 1H NMR-MS-based heterocovariance as a drug discovery tool for fishing bioactive compounds out of a complex mixture of structural analogues. Scientific Reports, 9, [11113]. https://doi.org/10.1038/s41598-019-47434-8
Nirantharakumar, K., Subramanian, A., Gokhale, K., Mollan, S., & Sinclair, A. (Accepted/In press). Idiopathic intracranial hypertension and risk of cardiovascular diseases in women: UK population based matched cohort study. JAMA Neurology.
Elhassan, Y., Alahdab, F., Prete, A., Delivanis, D., Khanna, A., Prokop, L., Murad, M. H., O'reilly, M., Arlt, W., & Bancos, I. (2019). Natural history of adrenal incidentalomas with and without mild autonomous cortisol excess: a systematic review and meta-analysis. Annals of internal medicine, 171(2), 107-116. https://doi.org/10.7326/M18-3630
Harrison, S. R., Li, D., Jeffery, L. E., Raza, K., & Hewison, M. (2019). Vitamin D, Autoimmune Disease and Rheumatoid Arthritis. Calcified Tissue International. https://doi.org/10.1007/s00223-019-00577-2
Salem, V., Delgadillo Silva, L., Suba, K., Georgiades, E., Mousavy Gharavy, S. N., Akhtar, N., Martin-Alonso, A., Gaboriau, D. C. A., Rothery, S. M., Stylianides, T., Carrat, G., Pullen, T. J., Pal Singh, S., Hodson, D., Leclerc, I., Shapiro, A. M. J., Marchetti, P., Briant, L. J. B., Distaso, W., ... Rutter, G. A. (2019). Leader β-cells coordinate Ca²⁺dynamics across pancreatic islets in vivo. Nature, 1, 615-629. https://doi.org/10.1038/s42255-019-0075-2
Crowe, F., Jolly, K., MacArthur, C., Manaseki-Holland, S., Gittoes, N., Hewison, M., Scragg, R., & Nirantharakumar, K. (2019). Trends in the incidence of testing for vitamin D deficiency in primary care in the UK: a retrospective analysis of The Health Improvement Network (THIN), 2005-2015. BMJ open, 9(6), [e028355]. https://doi.org/10.1136/bmjopen-2018-028355
Beentjes, C. H. L., Taylor-King, J. P., Bayani, A., Davis, C. N., Dunster, J. L., Jabbari, S., Mirams, G. R., Jenkinson, C., Kilby, M., Hewison, M., & Tamblyn, J. A. (2019). Defining vitamin D status using multi-metabolite mathematical modelling: a pregnancy perspective. The Journal of Steroid Biochemistry and Molecular Biology, 190, 152-160. https://doi.org/10.1016/j.jsbmb.2019.03.024
Mitchell, J., Mollan, S., Vijay, V., & Sinclair, A. (2019). Novel advances in monitoring and therapeutic approaches in idiopathic intracranial hypertension. Current opinion in neurology, 32(3), 422-431. https://doi.org/10.1097/WCO.0000000000000690
Kahal, H., Kyrou, I., Uthman, O. A., Brown, A., Johnson, S., Wall, P. D. H., Metcalfe, A., Parr, D. G., Tahrani, A. A., & Randeva, H. S. (2019). The prevalence of obstructive sleep apnoea in women with polycystic ovary syndrome: a systematic review and meta-analysis. Sleep and Breathing. https://doi.org/10.1007/s11325-019-01835-1
Subramanian, A., Adderley, N. J., Tracy, A., Taverner, T., Hanif, W., Toulis, K. A., Thomas, G. N., Tahrani, A. A., & Nirantharakumar, K. (2019). Risk of incident obstructive sleep apnea among patients with type 2 diabetes. Diabetes Care, 42(5), 954-963. https://doi.org/10.2337/dc18-2004
Thakker, A., Nasteska, D., & Cuozzo, F. (2019). Prolyl-hydroxylase 3 regulates β-cell phenotype under obesogenic conditions.
Edmunds, M., & Boelaert, K. (2019). Knowledge of thyroid eye disease in Graves’ Disease patients with and without orbitopathy. Thyroid, 29(4), 557-562. https://doi.org/10.1089/thy.2018.0665
Balachandran, K., Sumilo, D., O'Reilly, M. W., Toulis, K. A., Gokhale, K., Wijeyaratne, C., Coomarasamy, A., Arlt, W., Tahrani, A., & Nirantharakumar, K. (2019). Increased risk of obstructive sleep apnoea in women with polycystic ovary syndrome: a population-based cohort study. European Journal of Endocrinology, 180(4), 265-272. https://doi.org/10.1530/EJE-18-0693
Chortis, V., May, C. J. H., Skordilis, K., Ayuk, J., Arlt, W., & Crowley, R. K. (2019). Double trouble: two cases of dual adrenal pathologies in one adrenal mass. Endocrinology, diabetes & metabolism case reports, 2019, [EDM180151]. https://doi.org/10.1530/EDM-18-0151
OʼReilly, M. W., Westgate, C., Hornby, C., Botfield, H., Taylor, A., Markey, K., Mitchell, J., Scotton, W., Mollan, S., Yiangou, A., Jenkinson, C., Gilligan, L., Sherlock, M., Gibney, J., Tomlinson, J. W., Lavery, G., Hodson, D., Arlt, W., & Sinclair, A. (2019). A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics. JCI Insight, 4(6), [e125348]. https://doi.org/10.1172/jci.insight.125348
Idkowiak, J., Elhassan, Y. S., Mannion, P., Smith, K., Webster, R., Saraff, V., Barrett, T. G., Shaw, N. J., Krone, N., Dias, R. P., Kershaw, M., Kirk, J. M., Högler, W., Krone, R. E., O'Reilly, M. W., & Arlt, W. (2019). Causes, patterns and severity of androgen excess in 487 consecutively recruited pre- and post-pubertal children. European Journal of Endocrinology , 180(3), 213-221. https://doi.org/10.1530/EJE-18-0854
Lavrentaki, A., Ali, A., Cooper, B. G., & Tahrani, A. A. (2019). Mechanisms of endocrinology: mechanisms of disease: the endocrinology of obstructive sleep apnoea. European Journal of Endocrinology , 180(3), R91-R125. https://doi.org/10.1530/EJE-18-0411
Li, D., Jeffery, L. E., Jenkinson, C., Harrison, S. R., Chun, R. F., Adams, J. S., Raza, K., & Hewison, M. (2019). Serum and synovial fluid vitamin D metabolites and rheumatoid arthritis. The Journal of Steroid Biochemistry and Molecular Biology, 187, 1-8. https://doi.org/10.1016/j.jsbmb.2018.10.008
Yip, S., Romano, N., Gustafson, P., Hodson, D., Williams, E., Kokay, I., Martin, A. O., Mollard, P., Grattan, D., & Bunn, S. (2019). Elevated prolactin during pregnancy drives a phenotypic switch in mouse hypothalamic dopaminergic neurons. Cell Reports, 26(7), 1787-1799. https://doi.org/10.1016/j.celrep.2019.01.067
Mollan, S., Hoffmann, J., & Sinclair, A. (2019). Advances in the understanding of headache in idiopathic intracranial hypertension. Current opinion in neurology, 32(1), 92–98. https://doi.org/10.1097/WCO.0000000000000651
Bathon, K., Wigand, I., Vanselow, J. T., Ronchi, C., Sbiera, S., Schlosser, A., Calebiro, D., & Fassnacht, M. (2019). Alterations in protein kinase A substrate specificity as a potential cause of Cushing’s Syndrome. Endocrinology, 160(2), 447-459. https://doi.org/10.1210/en.2018-00775
Thomson, W., Jabbari, S., Taylor, A. E., Arlt, W., & Smith, D. (2019). Simultaneous parameter estimation and variable selection via the logit-normal continuous analogue of the spike-and-slab prior. Journal of The Royal Society Interface, 16(150), 20180572. [20180572]. https://doi.org/10.1098/rsif.2018.0572
Welch, C., Greig, C. A., Hassan-Smith, Z. K., Pinkney, T. D., Lord, J. M., & Jackson, T. A. (2019). A pilot observational study measuring acute sarcopenia in older colorectal surgery patients. BMC Research Notes, 12(1), [24]. https://doi.org/10.1186/s13104-019-4049-y
O'reilly, M., Glisic, M., Kumarendran, B., Subramanian, A., Manolopoulos, K., Tahrani, A., Keerthy, D., Muka, T., Toulis, K., Hanif, W., Thomas, G. N., Franco, O. H., Arlt, W., & Nirantharakumar, K. (2019). Serum testosterone, sex hormone-binding globulin and sex-specific risk of incident type 2 diabetes in a retrospective primary care cohort. Clinical Endocrinology, 90(1), 145-154. https://doi.org/10.1111/cen.13862
Lithgow, K., Pohl, U., & Karavitaki, N. (2019). Craniopharyngiomas. In KR. Feingold, B. Anawalt, & A. Boyce (Eds.), EndoText MD Text.com. https://www.ncbi.nlm.nih.gov/books/NBK538819/
Antza, C., Nirantharakumar, K., Doundoulakis, I., Tahrani, A. A., & Toulis, K. A. (2019). The development of an oral GLP-1 receptor agonist for the management of type 2 diabetes: evidence to date. Drug design, development and therapy, 13, 2985-2996. https://doi.org/10.2147/DDDT.S166765
Karavitaki, N. (2018). Recurrence in silent corticotroph adenomas after primary treatment: A systematic review and meta-analysis. Journal of Clinical Endocrinology and Metabolism, 104(4), 1039-1048. https://doi.org/10.1210/jc.2018-01956
Mollan, S. P., Hornby, C., Mitchell, J., & Sinclair, A. J. (2018). Evaluation and management of adult idiopathic intracranial hypertension. Practical Neurology, 18(6), 485-488. https://doi.org/10.1136/practneurol-2018-002009
Hornby, C., Mollan, S., Botfield, H., OʼReilly, M. W., & Sinclair, A. (2018). Metabolic Concepts in Idiopathic Intracranial Hypertension and Their Potential for Therapeutic Intervention. Journal of Neuro-Ophthalmology, 38(4), 522–530. https://doi.org/10.1097/WNO.0000000000000684
Lippert, J., Appenzeller, S., Liang, R., Sbiera, S., Kircher, S., Altieri, B., Nanda, I., Weigand, I., Gehrig, A., Steinhauer, S., Riemens, R. JM., Rosenwald, A., Mueller, C. R., Kroiss, M., Rost, S., Fassnacht, M., & Ronchi, C. (2018). Targeted molecular analysis in adrenocortical carcinomas: a strategy towards improved personalized prognostication. Journal of Clinical Endocrinology and Metabolism, 103(12), 4511–4523. https://doi.org/10.1210/jc.2018-01348
Nachtigall, L. B., Karavitaki, N., Kiseljak-Vassiliades, K., Ghalib, L., Fukuoka, H., Syro, L. V., Kelly, D., & Fleseriu, M. (2018). Physicians' awareness of gadolinium retention and MRI timing practices in the longitudinal management of pituitary tumors: a "Pituitary Society" survey. Pituitary. https://doi.org/10.1007/s11102-018-0924-0
Patel, K., Smith, T. B., Neil, D. A., Thakker, A., Tsuchiya, Y., Higgs, E. B., Hodges, N. J., Ready, A. R., Nath, J., & Ludwig, C. (2018). The effects of oxygenation on ex vivo kidneys undergoing Hypothermic Machine Perfusion. Transplantation. https://doi.org/10.1097/TP.0000000000002542
Gorvin, C. M., Newey, P. J., Rogers, A., Stokes, V., Neville, M. J., Lines, K. E., Ntali, G., Lees, P., Morrison, P. J., Singhellakis, P. N., Malandrinou, F. C., Karavitaki, N., Grossman, A. B., Karpe, F., & Thakker, R. V. (2018). Association of prolactin receptor (PRLR) variants with prolactinomas. Human Molecular Genetics. https://doi.org/10.1093/hmg/ddy396
Abbott, S., Dindol, N., Tahrani, A. A., & Piya, M. K. (2018). Binge eating disorder and night eating syndrome in adults with type 2 diabetes: a systematic review. Journal of Eating Disorders, 6. https://doi.org/10.1186/s40337-018-0223-1
Gorvin, C. M., Ahmad, B., Stechman, M., Loh, N., Hough, T., Leo, P., Marshall, M., Sethi, S., Bentley, L., Piret, S., Reed, A., Jeyabalan, J., Christie, P., Wells, S., Simon, M., Mallon, A-M., Schulz, H., Huebner, N., Brown, M., ... Thakker, R. (2018). An N-ethyl-N-nitrosourea (ENU)-induced Tyr265Stop mutation of the DNA polymerase accessory subunit gamma 2 (Polg2) is associated with renal calcification in mice. Journal of Bone and Mineral Research. https://doi.org/10.1002/jbmr.3624
Hodson, D. (2018). A niche mechanism for β-cell regeneration in type 1 diabetes. BioEssays, 40(11), [1800177]. https://doi.org/10.1002/bies.201800177
Prete, A., Yan, Q., Al-Tarrah, K., Akturk, H., Prokop, L., Alahdab, F., Foster, M. A., Lord, J., Karavitaki, N., Wass, J., Murad, M., Arlt, W., & Bancos, I. (2018). The cortisol stress response induced by surgery: a systematic review and meta-analysis. Clinical Endocrinology, 554-567. https://doi.org/10.1111/cen.13820
Benninger, R. K. P., Dorrell, C., Hodson, D., & Rutter, G. A. (2018). The impact of pancreatic beta cell heterogeneity on type 1 diabetes pathogenesis. Current Diabetes Reports, 18(11), [112]. https://doi.org/10.1007/s11892-018-1085-2
Mollan, S., Aguiar, M., Evison, F., Frew, E., & Sinclair, A. (2018). The expanding burden of Idiopathic Intracranial Hypertension. Eye. https://doi.org/10.1038/s41433-018-0238-5
UK10K Consortium (2018). Homozygous loss-of-function mutations in SLC26A7 cause goitrous congenital hypothyroidism. JCI Insight, 3(20), [e99631]. https://doi.org/10.1172/jci.insight.99631
Bunte, K., Smith, D., Chappell, M. J., Hassan-Smith, Z., Tomlinson, J., Arlt, W., & Tino, P. (2018). Learning pharmacokinetic models for in vivo glucocorticoid activation. Journal of Theoretical Biology, 455, 222-231. https://doi.org/10.1016/j.jtbi.2018.07.025
Jenkinson, C., Taylor, A., Storbeck, K-H., & Hewison, M. (2018). Data comparing the separation and elution of vitamin D metabolites on an ultra performance supercritical fluid chromatography tandem-mass spectrometer (UPSFC-MS/MS) compared to liquid chromatography (LC) and data presenting approaches to UPSFC method optimization. Data in Brief, 20, 426-435. https://doi.org/10.1016/j.dib.2018.08.027
Fountas, A., Chai, S. T., Kourkouti, C., & Karavitaki, N. (2018). Mechanisms in endocrinology: endocrinology of opioids. European Journal of Endocrinology, 179(4), R183–R196. https://doi.org/10.1530/EJE-18-0270
Mollan, SP., Davis, B., Silver, NC., Shaw, S., Malucci, C., Wakerley, BR., Krishnan, A., Chavda, S., Ramalingam, S., Edwards, J., Hemmings, K., Williamson, M., Burdon, MA., Hassan-Smith, Z., Digre, K., Liu, GT., Jensen, R., & Sinclair, A. (2018). Idiopathic intracranial hypertension: consensus guidelines on management. Journal of Neurology Neurosurgery and Psychiatry, 89, 1088-1100. https://doi.org/10.1136/jnnp-2017-317440
Ronchi, C. (2018). Adrenocortical tumours: challenges and recent advances in diagnosis and treatment. Minerva endocrinologica. https://doi.org/10.23736/S0391-1977.18.02915-2
Willemsen, R. H., Burling, K., Barker, P., Ackland, F., Dias, R. P., Edge, J., Smith, A., Todd, J., Lopez, B., Mander, A. P., Guy, C., & Dunger, D. B. (2018). Frequent Monitoring of C-Peptide Levels in Newly Diagnosed Type 1 Subjects Using Dried Blood Spots Collected at Home. The Journal of clinical endocrinology and metabolism, 103(9), 3350-3358. https://doi.org/10.1210/jc.2018-00500
Sahloul, M., Karim, A., Chohan, K. S., Tahrani, A. A., Mahawar, K., Richardson, M., Ludwig, C., Daskalakis, M., & Singhal, R. (2018). Roux-en-Y Gastric Bypass: Does the Direction of Staples Matter? Obesity surgery, 28(9), 2868-2873. https://doi.org/10.1007/s11695-018-3275-z
Chetan, M. R., Charlton, M. H., Thompson, C., Dias, R. P., Andrews, R. C., & Narendran, P. (2018). The Type 1 diabetes 'honeymoon' period is five times longer in men who exercise: a case-control study. Diabetic Medicine. https://doi.org/10.1111/dme.13802
Adolf, C., Köhler, A., Franke, A., Lang, K., Riester, A., Löw, A., Heinrich, D. A., Bidlingmaier, M., Treitl, M., Ladurner, R., Beuschlein, F., Arlt, W., & Reincke, M. (2018). Cortisol excess in patients with primary aldosteronism impacts on left ventricular hypertrophy. Journal of Clinical Endocrinology and Metabolism, 103(12), 4543-4552. https://doi.org/doi.org/10.1210/jc.2018-00617
Foster, P., & Mueller, J. W. (2018). Sulfation pathways: Insights into steroid sulfation and desulfation pathways. Journal of Molecular Endocrinology, 61(2), T271–T283. https://doi.org/10.1530/JME-18-0086
Hardy, R., Fenton, C., Croft, A., Naylor, A., Begum, R., Desanti, G., Buckley, C., Lavery, G., Cooper, M. S., & Raza, K. (2018). 11 beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis. Journal of Autoimmunity, 92, 104-113. https://doi.org/10.1016/j.jaut.2018.05.010
Chortis, V., Taylor, A., Doig, C., Walsh, M., Meimaridou, E., Jenkinson, C., Rodriguez Blanco, G., Ronchi, C., Jaffri, A., Metherell, L. A., Hebenstreit, D., Dunn, W., Arlt, W., & Foster, P. (2018). Nicotinamide nucleotide transhydrogenase as a novel treatment target in adrenocortical carcinoma. Endocrinology, 159(8), 2836–2849. https://doi.org/10.1210/en.2018-00014
Fehrentz, T., Huber, F., Hartrampf, N., Bruegmann, T., Frank, J., Fine, N., Malan, D., Danzl, J., Tikhonov, D., Sumser, M., Sasse, P., Hodson, D., Zhorov, B., Nikolaj, K., & Trauner, D. (2018). Optical control of L-Type Ca2+ channels using a diltiazem photoswitch. Nature Chemical Biology, 14, 764-767. https://doi.org/10.1038/s41589-018-0090-8
De Bray, A., Hassan-Smith, Z., Dirie, J., Littleton, E., Chavda, S., Ayuk, J., Sanghera, P., & Karavitaki, N. (2018). Macroprolactinoma causing VI, X, XII cranial nerve palsies nearly 30 years after initial treatment. Endocrinology, Diabetes and Metabolism Case Reports , 2018(1). https://doi.org/10.1530/EDM-18-0053
Hodson, D., & Nasteska, D. (2018). The role of beta cell heterogeneity in islet function and insulin release. Journal of Molecular Endocrinology, 61, R43-R60. https://doi.org/10.1530/JME-18-0011
Kahal, H., Kyrou, I., Uthman, O., Brown, A., Johnson, S., Wall, P., Metcalfe, A., Tahrani, A. A., & Randeva, H. S. (2018). The association between obstructive sleep apnea and metabolic abnormalities in women with polycystic ovary syndrome: a systematic review and meta-analysis. Sleep, 41(7), [zsy085]. https://doi.org/10.1093/sleep/zsy085
Hodson, D. (2018). Androgen excess in pancreatic β-cells and neurons predisposes female mice to type 2 diabetes. JCI Insight. https://doi.org/10.1172/jci.insight.98607.
Yiangou, A., Mitchell, J., Markey, K. A., Scotton, W., Nightingale, P., Botfield, H., Ottridge, R., Mollan, S. P., & Sinclair, A. J. (2018). Therapeutic lumbar puncture for headache in idiopathic intracranial hypertension: Minimal gain, is it worth the pain? Cephalalgia. https://doi.org/10.1177/0333102418782192
Scotton, W. J., Botfield, H. F., Westgate, C. S., Mitchell, J. L., Yiangou, A., Uldall, M. S., Jensen, R. H., & Sinclair, A. J. (2018). Topiramate is more effective than acetazolamide at lowering intracranial pressure. Cephalalgia. https://doi.org/10.1177/0333102418776455
Santharam, S., Fountas, A., Tampourlou, M., Arlt, W., Ayuk, J., Gittoes, N., Toogood, A., & Karavitaki, N. (2018). Impact of menopause on outcomes in prolactinomas after dopamine agonist treatment withdrawal. Clinical Endocrinology. https://doi.org/10.1111/cen.13765
Schiffer, L., Adaway, J. E., Baranowski, E., Arlt, W., & Keevil, B. G. (2018). A novel high-throughput assay for the measurement of salivary progesterone by liquid chromatography tandem mass spectrometry. Annals of Clinical Biochemistry. https://doi.org/10.1177/0004563218780904
Mueller, J. W., Idkowiak, J., Gesteira, T. F., Vallet, C., Hardman, R., van den Boom, J., Dhir, V., Knauer, S. K., Rosta, E., & Arlt, W. (2018). Human DHEA sulfation requires direct interaction between PAPS synthase 2 and DHEA sulfotransferase SULT2A1. Journal of Biological Chemistry, 293(25), 9724-9735. https://doi.org/10.1074/jbc.RA118.002248
Scotton, W. J., Mollan, S. P., Botfield, H., Yiangou, A., Markey, K., Sinclair, A. J., Walters, T., Doughty, S., & Williamson, S. (2018). Characterising the patient experience of diagnostic lumbar puncture in idiopathic intracranial hypertension: a cross-sectional online survey. BMJ open, 8(5), [e020445]. https://doi.org/10.1136/bmjopen-2017-020445
Janjuha, S., Pal Singh, S., Tsakmaki, A., Mousavy Gharavy, N., Murawala, P., Konantz, J., Birke, S., Hodson, D., Rutter, G., Bewick, G., & Ninov, N. (2018). Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish. eLife. https://doi.org/10.7554/eLife.32965
Taylor, A., Storbeck, K-H., Hewison, M., & Jenkinson, C. (2018). Analysis of multiple vitamin D metabolites by ultra-performance supercritical fluid chromatography-tandem mass spectrometry (UPSFC-MS/MS). Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 1087-1088, 43-48. https://doi.org/10.1016/j.jchromb.2018.04.025
Benninger, R., & Hodson, D. (2018). New Understanding of β-Cell Heterogeneity and In Situ Islet Function. Diabetes, 537-547. https://doi.org/10.2337/dbi17-0040
Karamat, M. A., Dar, S., Bellary, S., & Tahrani, A. A. (2018). Clinical and Cost Implications of Insulin Degludec in Patients with Type 1 Diabetes and Problematic Hypoglycemia: A Quality Improvement Project. Diabetes therapy : research, treatment and education of diabetes and related disorders, 9(2), 839-849. https://doi.org/10.1007/s13300-018-0400-x
Tampourlou, M., Fountas, A., Ntali, G., & Karavitaki, N. (2018). Mortality in patients with non-functioning pituitary adenoma. Pituitary, 21(2), 203–207. https://doi.org/10.1007/s11102-018-0863-9
Webb, E., Elliott, L., Carlin, D., Wilson, M., Hall, K., Netherton, J., Reed, J., Barrett, T., Salwani, V., Clayden, J., Arlt, W., Krone, N., Peet, A., & Wood, A. (2018). Quantitative brain MRI in congenital adrenal hyperplasia: in vivo assessment of the cognitive and structural impact of steroid hormones. Journal of Clinical Endocrinology and Metabolism, 103(4), 1330-1341. https://doi.org/10.1210/jc.2017-01481, https://doi.org/10.1210/jc.2017-01481
Hodson, D., & Da Silva Xavier, G. (2018). Mouse models of peripheral metabolic disease. Best practice & research. Clinical endocrinology & metabolism. https://doi.org/10.1016/j.beem.2018.03.009
Gorvin, C. (2018). Insights into calcium-sensing receptor trafficking and biased signalling by studies of calcium homeostasis. Journal of Molecular Endocrinology. https://doi.org/10.1530/JME-18-0049
Kumarendran, B., O'Reilly, M., Manolopoulos, K., Toulis, K., Gokhale, K., Sitch, A., Wijeyaratne, C. N., Coomarasamy, A., Arlt, W., & Nirantharakumar, K. (2018). Polycystic ovary syndrome, androgen excess, and the risk of nonalcoholic fatty liver disease in women: a longitudinal study based on a United Kingdom primary care database. PLoS Medicine, 15(3), [e1002542]. https://doi.org/10.1371/journal.pmed.1002542
Mistry, P., Currie, V., Super, P., le Roux, C. W., Tahrani, A. A., & Singhal, R. (2018). Changes in glycaemic control, blood pressure and lipids 5 years following laparoscopic adjustable gastric banding combined with medical care in patients with type 2 diabetes: a longitudinal analysis. Clinical Obesity. https://doi.org/10.1111/cob.12244
Elhassan, Y., Idkowiak, J., Smith, K., Asia, M., Gleeson, H., Webster, R., Arlt, W., & O'reilly, M. (2018). Causes, patterns, and severity of androgen excess in 1205 consecutively recruited women. The Journal of clinical endocrinology and metabolism, 103(3), 1214-1223. https://doi.org/10.1210/jc.2017-02426
Torlinska, B., Bath, S. C., Janjua, A., Boelaert, K., & Chan, S-Y. (2018). Iodine Status during Pregnancy in a Region of Mild-to-Moderate Iodine Deficiency is not Associated with Adverse Obstetric Outcomes; Results from the Avon Longitudinal Study of Parents and Children (ALSPAC). Nutrients, 10(3), [291]. https://doi.org/10.3390/nu10030291
Fountas, A., Chai, S. T., Ayuk, J., Gittoes, N., Chavda, S., & Karavitaki, N. (2018). A rare challenging case of co-existent craniopharyngioma, acromegaly and squamous cell lung cancer. Endocrinology, Diabetes and Metabolism Case Reports , [18-0018]. https://doi.org/10.1530/EDM-18-0018
Iniguez-Ariza, N., Kohlenberg, J., Delivanis, D., Hartman, R., Dean, D., Thomas, M., Shah, M., Herndon, J., McKenzie, T., Arlt, W., Young, W. F., & Bancos, I. (2018). Clinical, biochemical, and radiological characteristics of a single-center retrospective cohort of 705 large adrenal tumors. Mayo Clinic Proceedings. Innovations, Quality and Outcomes, 2(1), 30-39. https://doi.org/10.1016/j.mayocpiqo.2017.11.002
Jeffery, L., Henley, P., Marium, N., Filer, A., Sansom, D. M., Hewison, M., & Raza, K. (2018). Decreased sensitivity to 1,25-dihydroxyvitamin D3 in T cells from the rheumatoid joint. Journal of Autoimmunity, 88, 50-60. https://doi.org/10.1016/j.jaut.2017.10.001
Podewin, T., Ast, J., Broichhagen, J., Fine, N., Nasteska, D., Leippe, P., Gailer, M., Buenaventura, T., Kanda, N., Jones, B., N'Kadmi, C., Baneres, J-L., Marie, J., Tomas, A., Trauner, D., Hoffmann-Roder, A., & Hodson, D. (2018). Conditional and reversible activation of class A and B G protein-coupled receptors using tethered pharmacology. ACS Central Science, 4(2), 166-179. https://doi.org/10.1021/acscentsci.7b00237
McCloskey, E., Johansson, H., Harvey, N. C., Shepstone, L., Lenaghan, E., Fordham, R., Harvey, I., Howe, A., Cooper, C., Clarke, S., Gittoes, N., Heawood, A., Holland, R., Marshall, T., O'Neill, T. W., Peters, T. J., Redmond, N., Torgerson, D., Kanis, J. A., & SCOOP Study Team (2018). Management of patients with high baseline hip fracture risk by FRAX reduces hip fractures - a post hoc analysis of the SCOOP Study. Journal of Bone and Mineral Research. https://doi.org/10.1002/jbmr.3411
Turner, D. A., Fong Soe Khioe, R., Shepstone, L., Lenaghan, E., Cooper, C., Gittoes, N., Harvey, N., Holland, R., Howe, A., McCloskey, E., O'Neill, T., Torgerson, D., & Fordham, R. (2018). The cost-effectiveness of screening in the community to reduce osteoporotic fractures in older women in the UK: economic evaluation of the SCOOP study. Journal of Bone and Mineral Research. https://doi.org/10.1002/jbmr.3381
Karavitaki, N. (2018). Non-functioning pituitary adenomas, not all the same and certainly not boring! Pituitary. https://doi.org/10.1007/s11102-018-0875-5
Laufs, V., Altieri, B., Sbiera, S., Kircher, S., Steinhauer, S., Beuschlein, F., Quinkler, M., Willenberg, H. S., Rosenwald, A., Fassnacht, M., & Ronchi, C. (2018). ERCC1 as predictive biomarker to platinum-based chemotherapy in adrenocortical carcinomas. European Journal of Endocrinology, 178, 181-188. https://doi.org/10.1530/EJE-17-0788
Fine, N., Doig, C., Elhassan, Y., Vierra, N., Marchetti, P., Bugliani, M., Nano, R., Piemonti, L., Rutter, G., Jacobson, D. A., Lavery, G., & Hodson, D. (2018). Glucocorticoids reprogram ß-cell signaling to preserve insulin secretion. Diabetes, 67(2), 278-290. https://doi.org/10.2337/db16-1356
Tahrani, A. A., Bellary, S., & Barnett, A. H. (2018). Once-weekly GLP-1R agonists: Moving the goal posts. The Lancet Diabetes and Endocrinology, 6(4), 260-261. https://doi.org/10.1016/S2213-8587(18)30049-4
Kennedy, A., Narendran, P., Andrews, R. C., Daley, A., Greenfield, S. M., & EXTOD Group (2018). Attitudes and barriers to exercise in adults with a recent diagnosis of type 1 diabetes: a qualitative study of participants in the Exercise for Type 1 Diabetes (EXTOD) study. BMJ open, 8(1), [e017813]. https://doi.org/10.1136/bmjopen-2017-017813
Gorvin, C. M., Rogers, A., Hastoy, B., Tarasov, A. I., Frost, M., Sposini, S., Inoue, A., Whyte, M. P., Rorsman, P., Hanyaloglu, A. C., Breitwieser, G. E., & Thakker, R. V. (2018). AP2σ mutations impair calcium-sensing receptor trafficking and signaling, and show an endosomal pathway to spatially direct G-Protein selectivity. Cell Reports, 22(4), 1054-1066. https://doi.org/10.1016/j.celrep.2017.12.089
Engels, M., Gehrmann, K., Falhammar, H., Webb, E. A., Nordenstrom, A., Sweep, F., Span, P. N., van Herwaarden, A. E., Rohayem, J., Richter-Unruh, A., Bouvattier, C., Koehler, B., Kortmann, B. B., Arlt, W., Roeleveld, N., Reisch, N., Stikkelbroeck, N., & Claahsen-van der Grinten, H. L. (2018). Gonadal Function in Adult Male Patients with Congenital Adrenal Hyperplasia. European Journal of Endocrinology. https://doi.org/10.1530/EJE-17-0862
Chortis, V., Johal, N. J., Bancos, I., Evans, M., Skordilis, K., Guest, P., Cullen, M. H., Porfiri, E., & Arlt, W. (2018). Mitotane treatment in patients with metastatic testicular Leydig cell tutor associated with severe androgen excess. European Journal of Endocrinology. https://doi.org/10.1530/EJE-17-0542
Toulis, K., Bilezikian, J. P., Thomas, G. N., Hanif, W., Kotsa, K., Thayakaran, R., Keerthy, D., Tahrani, A., & Nirantharakumar, K. (2018). Initiation of dapagliflozin and treatment-emergent fractures. Diabetes, obesity & metabolism, 20(4), 1070-1074. https://doi.org/10.1111/dom.13176
Aojula, A., Mollan, S., Horsburgh, J., Yiangou, A., Markey, K., Mitchell, J., Scotton, W., Keane, P., & Sinclair, A. (2018). Segmentation Error in Spectral Domain Optical Coherence Tomography measures of the retinal nerve fibre layer thickness in idiopathic intracranial hypertension. BMC Ophthalmology, 17, [257]. https://doi.org/10.1186/s12886-017-0652-7
Meimaridou, E., Goldsworthy, M., Chortis, V., Fragouli, E., Foster, P. A., Arlt, W., Cox, R., & Metherell, L. A. (2018). NNT is a key regulator of adrenal redox homeostasis and steroidogenesis in male mice. Journal of Endocrinology, 236, 13-28. https://doi.org/10.1530/JOE-16-0638
Tamblyn, J., Jenkinson, C., Larner, D., Hewison, M., & Kilby, M. (2018). Serum and urine vitamin D metabolite analysis in early preeclampsia. Endocrine Connections, 7(1), 199-210. https://doi.org/10.1530/EC-17-0308
Arlt, W., & Idkowiak, J. (2018). Monogenic disorders of adrenal steroidogenesis. Hormone Research in Paediatrics, 89, 292–310. https://doi.org/10.1159/000488034
Karavitaki, N., Toulis, K., Kumarendran, B., Gokhale, K., Cheng, K., & Nirantharakumar, K. (2017). Males with prolactinoma are at increased risk of incident cardiovascular disease. Clinical Endocrinology, 88(1), 71-76. https://doi.org/10.1111/cen.13498
Dohle, W., Jourdan, F. L., Menchon, G., Prota, A. E., Foster, P. A., Mannion, P., Hamel, E., Thomas, M. P., Kasprzyk, P. G., Ferrandis, E., Steinmetz, M. O., Leese, M. P., & Potter, B. V. L. (2017). Quinazolinone-based Anticancer Agents: Synthesis, Anti-proliferative SAR, Anti-tubulin Activity and Tubulin Co-crystal Structure. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.7b01474
Gilligan, L., Rahman, H., Hewitt, A-M., Sitch, A., Gondal, A., Arvaniti, A., Taylor, A., Read, M., Morton, D., & Foster, P. (2017). Estrogen activation by steroid sulfatase increases colorectal cancer proliferation via GPER. Journal of Clinical Endocrinology and Metabolism, 102(12), 4435-4447. https://doi.org/10.1210/jc.2016-3716
Eachus, H., Zaucker, A., Oakes, J. A., Griffin, A., Weger, M., Güran, T., Taylor, A., Harris, A., Greenfield, A., Quanson, J. L., Storbeck, K-H., Cunliffe, V. T., Müller, F., & Krone, N. (2017). Genetic disruption of 21-hydroxylase in zebrafish causes interrenal hyperplasia. Endocrinology, 158(12), 4165-4173. https://doi.org/10.1210/en.2017-00549
Annane, D., Pastores, S., Arlt, W., Balk, R., Beishuizen, A., Briegel, J., Carcillo, J., Christ-Crain, M., Cooper, M. S., Marik, P., Umberto Meduri, G., Olsen, K., Rochwerg, B., Rodgers, S., Russell, J., & Van den Berghe, G. (2017). Critical Illness-Related Corticosteroid Insufficiency (CIRCI): A Narrative Review from a Multispecialty Task Force of the Society of Critical Care Medicine (SCCM) and the European Society of Intensive Care Medicine (ESICM). Intensive Care Medicine, 43(12), 1781-1792. https://doi.org/10.1007/s00134-017-4914-x
Lissauer, D., Kilby, M. D., & Moss, P. (2017). Maternal effector T cells within decidua: The adaptive immune response to pregnancy? Placenta, 60, 140-144. https://doi.org/10.1016/j.placenta.2017.09.003
Hewison, M., Fleet, J. C., Demay, M. B., Christakos, S., Bouillon, R., Welsh, J., & White, J. H. (2017). Highlights from the 20th Workshop on Vitamin D in Orlando, Mar. 28-31, 2017. The Journal of Steroid Biochemistry and Molecular Biology. https://doi.org/10.1016/j.jsbmb.2017.11.010
Tang, T., Abbott, S., le Roux, C. W., Wilson, V., Singhal, R., Bellary, S., & Tahrani, A. A. (2017). Preoperative weight loss with glucagon-like peptide-1 receptor agonist treatment predicts greater weight loss achieved by the combination of medical weight management and bariatric surgery in patients with type 2 diabetes: A longitudinal analysis. Diabetes, Obesity and Metabolism. https://doi.org/10.1111/dom.13131
Powell, R., Lissauer, D., Tamblyn, J., Beggs, A., Cox, P., Moss, P., & Kilby, M. (2017). Decidual T cells exhibit a highly differentiated phenotype and demonstrate potential fetal specificity and a strong transcriptional response to IFN. Journal of Immunology, 199(10), 3406-3417. https://doi.org/10.4049/jimmunol.1700114
Ganguly, A., Tamblyn, J. A., Finn-Sell, S., Chan, S-Y., Westwood, M., Gupta, J., Kilby, M., Gross, S. R., & Hewison, M. (2017). Vitamin D, the placenta and early pregnancy: effects on trophoblast function. Journal of Endocrinology. https://doi.org/10.1530/JOE-17-0491
Narendran, P., Jackson, N., Daley, A., Thompson, D., Stokes, K., Greenfield, S., Charlton, M., Curran, M., Solomon, T., Nouwen, A., Lee, S. I., Cooper, A. R., Mostazir, M., Taylor, R. S., Kennedy, A., & Andrews, R. C. (2017). Exercise to preserve β-cell function in recent-onset Type 1 diabetes mellitus (EXTOD) - a randomized controlled pilot trial. Diabetic Medicine, 34(11), 1521-1531. https://doi.org/10.1111/dme.13439
Fisher, V. L., & Tahrani, A. A. (2017). Cardiac autonomic neuropathy in patients with diabetes mellitus: Current perspectives. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 10, 419-434. https://doi.org/10.2147/DMSO.S129797
Christakos, S., White, J. H., Hewison, M., Welsh, J., Lips, P., Bouillon, R., & Demay, M. B. (2017). Highlights from the 19th Workshop on Vitamin D in Boston, March 29-31, 2016. The Journal of Steroid Biochemistry and Molecular Biology, 173, 1-4. https://doi.org/10.1016/j.jsbmb.2017.06.005
Bussler, S., Penke, M., Flemming, G., Kratzsch, J., Sergeyev, E., Lipek, T., Vogel, M., Spielau, U., Körner, A., de Giorgis, T., Kiess, W., & Elhassan, Y. (2017). Novel Insights in the Metabolic Syndrome in Childhood and Adolescence. Hormone Research in Paediatrics, 88(3-4), 181-193. https://doi.org/10.1159/000479510
Altaf, Q., Dodson, P., Ali, A., Raymond, N. T., Wharton, H., Fellows, H., Hampshire-Bancroft, R., Shah, M., Shepherd, E., Miah, J., Barnett, A. H., & Tahrani, A. (2017). Obstructive sleep apnoea and retinopathy in patients with type 2 diabetes: a longitudinal study. American Journal of Respiratory and Critical Care Medicine, 196(7), 892–900. https://doi.org/10.1164/rccm.201701-0175OC
Annane, D., Pastores, S., Rochwerg, B., Arlt, W., Briegel, J., Beishuizen, A., Balk, R., Carcillo, J., Christ-Crain, M., Cooper, M. S., Marik, P., Umberto Meduri, G., Olsen, K., Rodgers, S., Russell, J., & Van den Berghe, G. (2017). Guidelines for the diagnosis and management of critical illness related corticosteroid insufficiency (CIRCI) in critically ill adult and pediatric patients (Part I): Society of Critical Care Medicine (SCCM) and the European Society of Intensive Care Medicine (ESICM): 2017. Intensive Care Medicine. https://doi.org/10.1007/s00134-017-4919-5
Markey, K., Ottridge, R., Mitchell, J., Rick, C., Woolley, R., Ives, N., Nightingale, P., & Sinclair, A. (2017). Clinical Methods and Design for a Phase II Randomised Control Trial to Assess the Efficacy and Safety of an 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) in Idiopathic Intracranial Hypertension: IIH:DT. JMIR Research Protocols, 6(9), [ e181]. https://doi.org/10.2196/resprot.7806
Markey, K., Ottridge, R., Mitchell, J., Rick, C., Woolley, R., Ives, N., Nightingale, P., & Sinclair, A. (2017). Clinical Methods and Design for a Phase II Randomised Control Trial to Assess the Efficacy and Safety of an 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) in Idiopathic Intracranial Hypertension: IIH:DT. JMIR Research Protocols.
O'reilly, M., Kempegowda, P., Walsh, M., Taylor, A., Manolopoulos, K., Allwood, J. W., Semple, R. K., Hebenstreit, D., Dunn, W., Tomlinson, J., & Arlt, W. (2017). AKR1C3-mediated adipose androgen generation drives lipotoxicity in women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 102(9), 3327–3339. https://doi.org/10.1210/jc.2017-00947
Shipman, K. E., Doyle, A., Arden, H., Jones, T., & Gittoes, N. J. (2017). Development of fracture liaison services: What have we learned? Injury. https://doi.org/10.1016/j.injury.2017.08.030
Schiffer, L., Kempegowda, P., Arlt, W., & O'reilly, M. (2017). The sexually dimorphic role of androgens in human metabolic disease. European Journal of Endocrinology, 177, R125-R143. https://doi.org/10.1530/EJE-17-0124
Imruetaicharoenchoke, W., Fletcher, A., Lu, W., Watkins, RJ., Modasia, B., Poole, V., Nieto, H., Thompson, R., Boelaert, K., Read, M., Smith, V., & McCabe, C. (2017). Functional consequences of the first reported mutations of the proto-oncogene PTTG1IP/PBF. Endocrine-related cancer, 24(9), 459-474. https://doi.org/10.1530/ERC-16-0340
Rutter, G., Hodson, D. J., Chabosseau, P., Pullen, T. J., & Leclerc, I. (2017). Local and regional control of calcium dynamics in the pancreatic islet. Diabetes, Obesity and Metabolism, 19(Supplement 1), 30–41. https://doi.org/10.1111/dom.12990
Frank, J., Yushchenko, D., Fine, N., Duca, M., Citir, M., Broichhagen, J., Hodson, D., Schulz, C., & Trauner, D. (2017). Optical control of GPR40 signalling in pancreatic β-cells. Chemical Science. https://doi.org/10.1039/C7SC01475A
Botfield, H. F., Uldall, M. S., Westgate, C. S. J., Mitchell, J. L., Hagen, S. M., Gonzalez, A. M., Hodson, D. J., Jensen, R. H., & Sinclair, A. J. (2017). A glucagon-like peptide-1 receptor agonist reduces intracranial pressure in a rat model of hydrocephalus. Science Translational Medicine, 9(404), [eaan0972]. https://doi.org/10.1126/scitranslmed.aan0972
Roper, L. S., Nightingale, P., Su, Z., Mitchell, J. L., Belli, A., & Sinclair, A. J. (2017). Disability from posttraumatic headache is compounded by coexisting posttraumatic stress disorder. Journal of Pain Research, 10, 1991-1996. https://doi.org/10.2147/JPR.S129808
Shepherd, L. M., Tahrani, A. A., Inman, C., Arlt, W., & Carrick-Sen, D. M. (2017). Exploration of knowledge and understanding in patients with primary adrenal insufficiency: a mixed methods study. BMC Endocrine Disorders, 17(1), 47. https://doi.org/10.1186/s12902-017-0196-0
Shepherd, L. M., Tahrani, A. A., Inman, C., Arlt, W., & Carrick-Sen, D. M. (2017). Exploration of knowledge and understanding in patients with primary adrenal insufficiency: A mixed methods study. BMC Endocrine Disorders, 17(1), [47]. https://doi.org/10.1186/s12902-017-0196-0
Fletcher, R. S., Ratajczak, J., Doig, C. L., Oakey, L. A., Callingham, R., Da Silva Xavier, G., Garten, A., Elhassan, Y. S., Redpath, P., Migaud, M. E., Philp, A., Brenner, C., Canto, C., & Lavery, G. G. (2017). Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells. Molecular metabolism, 6(8), 819-832. https://doi.org/10.1016/j.molmet.2017.05.011
Jones, B. J., Scopelliti, R., Tomas, A., Hodson, D. J., & Broichhagen, J. (2017). Potent prearranged positive allosteric modulators of the glucagon-like peptide 1 receptor. Open Chemistry, 6(4), 501–505. https://doi.org/10.1002/open.201700062
Larkin, S., & Karavitaki, N. (2017). Recent advances in molecular pathology of craniopharyngioma. F1000Research, 6, [1202]. https://doi.org/10.12688/f1000research.11549.1
Santharam, S., Tampourlou, M., Arlt, W., Gittoes, N., Toogood, A. A., Webster, R., & Karavitaki, N. (2017). Prolactinomas diagnosed in the postmenopausal period: clinical phenotype and outcomes. Clinical Endocrinology. https://doi.org/10.1111/cen.13399
Liu, N., Larner, D., Yao, Q., Chun, R., Ouyang, Y. B., Zhou, R., Tamblyn, J., Wagner, C. L., & Hewison, M. (2017). Vitamin D-deficiency and sex-specific dysregulation of placental inflammation. The Journal of Steroid Biochemistry and Molecular Biology. https://doi.org/10.1016/j.jsbmb.2017.06.012, https://doi.org/10.1016/j.jsbmb.2017.06.012
Zielinska, A., Fletcher, R., Sherlock, M., Doig, C., & Lavery, G. (2017). Cellular and genetic models of H6PDH and 11β-HSD1 function in skeletal muscle. Cell Biochemistry & Function, 35(5), 269-277. https://doi.org/10.1002/cbf.3272
Hirschmann, F., Krause, F., Baruch, P., Chizhov, I., Mueller, J. W., Manstein, D. J., Papenbrock, J., & Fedorov, R. (2017). Structural and biochemical studies of sulphotransferase 18 from Arabidopsis thaliana explain its substrate specificity and reaction mechanism. Scientific Reports, 7, [4160]. https://doi.org/10.1038/s41598-017-04539-2
Kahal, H., Kyrou, I., Tahrani, A. A., & Randeva, H. S. (2017). Obstructive Sleep Apnoea and Polycystic Ovary Syndrome; a comprehensive review of clinical interactions and underlying pathophysiology. Clinical Endocrinology. https://doi.org/10.1111/cen.13392
Hornby, C., Botfield, H., O'reilly, M., Westgate, C., Mitchell, J., Mollan, S., Manolopoulos, K., Tomlinson, J., & Sinclair, A. (2017). Evaluating the fat distribution in Idiopathic Intracranial Hypertension using Dual energy X-ray absorptiometry scanning. Neuro-Ophthalmology. https://doi.org/10.1080/01658107.2017.1334218
Tahrani, A. A. (2017). Novel therapies in type 2 diabetes: insulin resistance. Practical Diabetes, 34(5), 161-166a. https://doi.org/10.1002/pdi.2109
Tahrani, A. A. (2017). Obstructive sleep apnoea in diabetes: Does it matter? Diabetes and Vascular Disease Research, 1479164117714397. https://doi.org/10.1177/1479164117714397
Altaf, QA., Dodson, P., Ali, A., Raymond, NT., Wharton, H., Fellows, H., Hampshire-Bancroft, R., Shah, M., Shepherd, E., Miah, J., Barnett, AH., & Tahrani, AA. (2017). Obstructive sleep apnoea and retinopathy in patients with Type 2 diabetes: A longitudinal study. American Journal of Respiratory and Critical Care Medicine, 196(7). https://doi.org/10.1164/rccm.201701-0175oc
Doig, C., Fletcher, R., Morgan, S., McCabe, E., Larner, D., Tomlinson, J., Stewart, P., Philp, A., & Lavery, G. (2017). 11β-HSD1 modulates the set-point of brown adipose tissue response to glucocorticoids in male mice. Endocrinology, 158(6), 1964-1976. https://doi.org/10.1210/en.2016-1722
Tampourlou, M., Ntali, G., Ahmed, S. K., Arlt, W., Ayuk, J., Byrne, J. V., Chavda, S., Cudlip, S., Gittoes, N., Grossman, A., Mitchell, R., O'reilly, M., Paluzzi, A., Toogood, A., Wass, J. AH., & Karavitaki, N. (2017). Outcome of non-functioning pituitary adenomas that regrow after primary treatment: a study from two large UK centers. Journal of Clinical Endocrinology and Metabolism, 102(6), 1889–1897. https://doi.org/10.1210/jc.2016-4061
Webb, E., Balasubramanian, M., Fratzl-Zelman, N., Cabral, W. A., Titherage, H., Alsaedi, A., Saraff, V., Vogt, J., Cole, T., Stewart, S., Crabtree, N., Sargent, B. M., Gamsjaeger, S., Paschalis, E. P., Roschger, P., Klaushofer, K., Shaw, N. J., Marini, J. C., & Högler, W. (2017). Phenotypic spectrum in osteogenesis imperfecta due to mutations in TMEM38B: unravelling a complex cellular defect. The Journal of clinical endocrinology and metabolism, 102(6), 2019-2028. https://doi.org/10.1210/jc.2016-3766
Bancos, I., & Arlt, W. (2017). Diagnosis of a malignant adrenal mass: the role of urinary steroid metabolite profiling. Current Opinion in Endocrinology and Diabetes, 24(3), 200–207.
Podewin, T., Broichhagen, J., Frost, C., Groneberg, D., Ast, J., Meyer-Berg, H., Fine, N. H. F., Friebe, A., Zacharias, M., Hodson, D. J., Trauner, D., & Hoffmann-Röder, A. (2017). Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone. Chemical Science, 8(6), 4644-4653. https://doi.org/10.1039/C6SC05044A
El-Maouche, D., Arlt, W., & Merke, D. P. (2017). Congenital Adrenal Hyperplasia: The Lancet Seminar Series. The Lancet. https://doi.org/10.1016/S0140-6736(17)31431-9
Philp, A. A., Lavery, G. G., & Elhassan, Y. (2017). Targeting NAD+ in Metabolic Disease: New Insights Into an Old Molecule. Endocrine pathology, 1(7), 816-835. https://doi.org/10.1210/js.2017-00092
Naylor, A., Desanti, G., Saghir, A., & Hardy, R. (2017). TNFα depleting therapy improves fertility and animal welfare in TNFα-driven transgenic models of polyarthritis when administered in their routine breeding. Laboratory Animals. https://doi.org/10.1177/0023677217707985
Sharples, A. J., Charalampakis, V., Daskalakis, M., Tahrani, A., & Singhal, R. (2017). Systematic review and meta-analysis of outcomes after revisional bariatric surgery following a failed adjustable gastric band. Obesity surgery. https://doi.org/10.1007/s11695-017-2677-7
Cegla, J., Gardiner, J. V., Hodson, D. J., Marjot, T., McGlone, E. R., Tan, T. M., & Bloom, S. R. (2017). RAMP2 influences glucagon receptor pharmacology via trafficking and signaling. Endocrinology.
O'Reilly, M., Kempegowda, P., Walsh, M., Taylor, A., Manolopoulos, K., Allwood, W., Semple, R., Hebenstreit, D., Dunn, W., Tomlinson, J., & Arlt, W. (2017). AKR1C3-mediated adipose androgen generation drives lipotoxicity in polycystic ovary syndrome. Endocrine Abstracts. https://doi.org/10.1530/endoabs.49.oc3.3
Scotney, H., Symonds, M. E., Law, J., Budge, H., Sharkey, D., & Manolopoulos, K. (2017). Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo. Metabolism, 70, 125-132. https://doi.org/10.1016/j.metabol.2017.01.024
Tampourlou, M., Arlt, W., Gittoes, N., O'reilly, M., & Karavitaki, N. (2017). Outcome of non-functioning pituitary adenomas that regrow after primary treatment: a study from two large specialist UK centers. Abstract from 19th European Congress of Endocrinology, Lisbon, Portugal. https://doi.org/10.1530/endoabs.49.GP180
Santharam, S., Tampourlou, M., Arlt, W., Ayuk, J., Gittoes, N., Toogood, A., Webster, R., & Karavitaki, N. (2017). Prolactinomas diagnosed after menopause: presentation and outcomes from a large specialist centre. Abstract from 19th European Congress of Endocrinology, Lisbon, Portugal. https://doi.org/10.1530/endoabs.49.EP1051
Lebbe, M., Taylor, A., Visser, J. A., Kirkman-Brown, J., Woodruff, T. K., & Arlt, W. (2017). The steroid metabolome in the isolated ovarian follicle and its response to androgen exposure and antagonism. Endocrinology, 158(5), 1474-1485. https://doi.org/10.1210/en.2016-1851
Arlt, W., Lang, K., Sitch, A., Dietz, A. S., Rhayem, Y., Bancos, I., Feuchtinger, A., Chortis, V., Gilligan, L., Ludwig, P., Riester, A., Asbach, E., Hughes, B., O'Neil, D., Bidlingmaier, M., Tomlinson, J. W., Hassan-Smith, Z., Rees, D. A., Adolf, C., ... Reincke, M. (2017). Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism. JCI Insight, 2(8), [e93136]. https://doi.org/10.1172/jci.insight.93136
Tahrani, A. A. (2017). Ethnic Differences In The Pathogenesis of Obstructive Sleep Apnoea: Exploring Non-Anatomical Factors. Respirology. https://doi.org/10.1111/resp.13057
Mitchell, R. K., Nguyen-Tu, M-S., Chabosseau, P., Callingham, R. M., Pullen, T. J., Cheung, R., Leclerc, I., Hodson, D. J., & Rutter, G. A. (2017). The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis and Ca2+ dynamics in adult mice. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.M117.784629
Manolopoulos, K. N., O'Reilly, M. W., Bujalska, I. J., Tomlinson, J. W., & Arlt, W. (2017). Acute hypercortisolemia exerts depot-specific effects on abdominal and femoral adipose tissue function. Journal of Clinical Endocrinology and Metabolism, 102(4), 1091-1101. https://doi.org/10.1210/jc.2016-3600
Bancos, I., Hazeldine, J., Chortis, V., Hampson, P., Taylor, A. E., Lord, J., & Arlt, W. (2017). Primary adrenal insufficiency is associated with impaired natural killer cell function: a potential link to increased mortality. European Journal of Endocrinology, 176(4), 471-480. https://doi.org/10.1530/EJE-16-0969
Welch, C., Hassan-Smith, Z., Greig, C., Lord, J., & Jackson, T. (2017). Acute Sarcopenia Secondary to Hospitalisation – An Emerging Condition Affecting Older Adults. Aging and Disease, 8(6). https://doi.org/10.14336/AD.2017.0315
Mehta, Z., Johnston, N., Nguyen-Tu, M-S., Broichhagen, J., Schultz, P. G., Larner, D., Leclerc, I., Trauner, D., Rutter, G., & Hodson, D. J. (2017). Remote control of glucose homeostasis in vivo using photopharmacology. Scientific Reports, 7, [291]. https://doi.org/10.1038/s41598-017-00397-0
Tahrani, A. (2017). Peripheral and Autonomic Neuropathy in South Asians and White Caucasians with Type 2 Diabetes Mellitus: Possible Explanations for Epidemiological Differences. Journal of Diabetes Research, [1273789]. https://doi.org/10.1155/2017/1273789
Weigel, M., Hahner, S., Sherlock, M., Agha, A., Behan, L. A., Stewart, P., Arlt, W., Beier, D., Frey, K., Zopf, K., & Quinkler, M. (2017). Immediate versus modified release hydrocortisone in mitotane-treated patients with adrenocortical cancer. Clinical Endocrinology, 86(4), 499-505. https://doi.org/10.1111/cen.13302
Gilligan, L., Gondal, A., Tang, V., Hussain, M. T., Arvaniti, A., Hewitt, A-M., & Foster, P. A. (2017). Estrone sulfate transport and steroid sulfatase activity in colorectal cancer: implications for Hormone Replacement Therapy. Frontiers in Pharmacology, 8, [103]. https://doi.org/10.3389/fphar.2017.00103
O'reilly, M., Kempegowda, P., Jenkinson, C., Taylor, A., Quanson, J. L., Storbeck, K-H., & Arlt, W. (2017). 11-oxygenated C19 steroids are the predominant androgens in polycystic ovary syndrome. The Journal of clinical endocrinology and metabolism, 102(3), 840-848. https://doi.org/10.1210/jc.2016-3285
May, C. J. H., Asis, M., Arlt, W., Guest, P., O'reilly, M., & Karavitaki, N. (2017). Bilateral adrenal haemorrhage. QJM: An International Journal of Medicine, 110(3), 169-171. https://doi.org/10.1093/qjmed/hcw212
Romanò, N., Guillou, A., Hodson, D. J., Martin, A. O., & Mollard, P. (2017). Multiple-scale neuroendocrine signals connect brain and pituitary hormone rhythms. National Academy of Sciences. Proceedings, 114(9), 2379–2382. https://doi.org/10.1073/pnas.1616864114
Hassan-Smith, Z. K., Jenkinson, C., Smith, D., Hernandez, I., Morgan, S., Crabtree, N. J., Gittoes, N., Keevil, B. G., Stewart, P. M., & Hewison, M. (2017). 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 exert distinct effects on human skeletal muscle function and gene expression. PLoS ONE, 12(2), [e0170665]. https://doi.org/10.1371/journal.pone.0170665
Poole, V., Fletcher, A., Modasia, B., Sharma, N., Thompson, R., Imruetaicharoenchoke, W., Read, M., Boelaert, K., McCabe, C., & Smith, V. (2017). Pharmacological enhancement of radioiodine uptake using Src kinase inhibitors. Thyroid Research, 10(Suppl 1)(2), 2. [O2]. https://doi.org/10.1186/s13044-016-0036-8
Gittoes, O., & Gittoes, N. (2017). Breathlessness and neck swelling after a rugby game. BMJ, 356, [j311]. https://doi.org/10.1136/bmj.j311
Puar, T., Engels, M., van Herwaarden, A., Sweep, F., Hulsbergen-van de Kaa, C., Kamphuis-van Ulzen, K., Chortis, V., Arlt, W., Stikkelbroeck, N., Claahsen-van der Grinten, H., & Hermus, A. (2017). Bilateral testicular tumors resulting in recurrent Cushing's syndrome after bilateral adrenalectomy. Journal of Clinical Endocrinology and Metabolism, 102(2), 339-344. https://doi.org/10.1210/jc.2016-2702
Tamblyn, J., Susarla, R., Jenkinson, C., Jeffery, L., Ohizua, O., Chun, R., Chan, S. Y., Kilby, M., & Hewison, M. (2017). Dysregulation of maternal and placental vitamin D metabolism in preeclampsia. Placenta, 50, 70-77. https://doi.org/10.1016/j.placenta.2016.12.019
Lavrentaki, A., Karavitaki, N., Paluzzi, A., & Wass, J. A. H. (2017). Epidemiology of Acromegaly: Review of population studies. Pituitary, 20(1), 4–9. https://doi.org/10.1007/s11102-016-0754-x
Dafoulas, G. E., Toulis, K., Mccorry, D., Kumarendran, B., Thomas, G. N., Willis, B. H., Gokhale, K., Gkoutos, G., Narendran, P., & Nirantharakumar, K. (2017). Type 1 diabetes mellitus and risk of incident epilepsy: a population-based, open-cohort study. Diabetologia, 60(2), 258-261. https://doi.org/10.1007/s00125-016-4142-x
Karamat, M. A., Raja, U. Y., Manley, S. E., Jones, A., Hanif, W., & Tahrani, A. A. (2017). Prevalence of undiagnosed type 2 diabetes in patients admitted with acute coronary syndrome: the utility of easily reproducible screening methods. BMC Endocrine Disorders, 17(3), [3]. https://doi.org/10.1186/s12902-017-0153-y
Amin, A., Ali, A., Altaf, QA., Piya, MK., Barnett, AH., Raymond, NT., & Tahrani, AA. (2017). Prevalence and associations of obstructive sleep apnea in South Asians and White Europeans with Type 2 diabetes: A cross-sectional study. The Journal of Clinical Sleep Medicine, 13(4). http://jcsm.aasm.org/ViewAbstract.aspx?pid=30993
Le Tissier, P., Campos, P., Lafont, C., Romano, N., Hodson, D., & Mollard, P. (2017). An updated view of hypothalamic–vascular–pituitary unit function and plasticity. Nature Reviews Endocrinology, 13, 257-267. https://doi.org/10.1038/nrendo.2016.193
Amin, A., Ali, A., Altaf, Q. A., Piya, M. K., Barnett, A. H., Raymond, N. T., & Tahrani, A. A. (2017). Prevalence and associations of obstructive sleep apnea in South Asians and White Europeans with type 2 diabetes: A cross-sectional study. The Journal of Clinical Sleep Medicine, 13(4), 583-589. https://doi.org/10.5664/jcsm.6548
Hornby, C., Mollan, S., Mitchell, J., Markey, K. A., Yangou, A., Wright, B., O'Reilly, M., & Sinclair, A. (2017). What do transgender patients teach us about Idiopathic Intracranial Hypertension? Neuro-Ophthalmology, 41(6), 326-329. https://doi.org/10.1080/01658107.2017.1316744
2016
Doig, C. L., & Lavery, G. G. (2016). PARP Inhibitors: Staying on Target? Cell Chemical Biology, 23(12), 1442-1443. https://doi.org/10.1016/j.chembiol.2016.12.003
Hornby, C., O'Reilly, M., Botfield, H., Markey, K., Kempegowda, P., Taylor, A., Hughes, B., Tomlinson, J., Arlt, W., & Sinclair, A. (2016). The Andro-metabolic signature of Idiopathic Intracranial Hypertension compared to Polycystic Ovary Syndrome and Simple Obesity. Journal of Neurology, Neurosurgery & Psychiatry, 87(12), e1.46-e1. https://doi.org/10.1136/jnnp-2016-315106.14
Hardy, R. S., Doig, C. L., Hussain, Z., O'Leary, M., Morgan, S. A., Pearson, M. J., Naylor, A., Jones, S., Filer, A., Stewart, P. M., Buckley, C. D., Lavery, G. G., Cooper, M. S., & Raza, K. (2016). 11β-hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation. Journal of Pathology, 240(4), 472-483. https://doi.org/10.1002/path.4806
Bancos, I., Alahdab, F., Crowley, R., Chortis, V., Delivanis, D., Erickson, D., Natt, N., Terzolo, M., Arlt, W., Young Jr, W., & Murad, M. H. (2016). Improvement of cardiovascular risk factors after adrenalectomy in patients with adrenal tumors and Subclinical Cushing Syndrome: a systematic review and meta-analysis. European Journal of Endocrinology, 175(6), R283-R295. https://doi.org/10.1530/EJE-16-0465
Altaf, Q. A., Sadiqi, H., Piya, M. K., & Tahrani, A. A. (2016). Foot insensitivity is associated with renal function decline in patients with type 2 diabetes: a cohort study. BMC Endocrine Disorders, 16(1), 64. https://doi.org/10.1186/s12902-016-0147-1
Belli, A., Roper, L. S., Nightingale, P., Su, Z., & Sinclair, A. (2016). Disability from post-traumatic headache is compounded by PTSD. British Medical Journal. http://10.1136/jnnp-2016-315106.72
Jones, C., Mallappa, A., Reisch, N., Nikolaou, N., Krone, N., Hughes, B., O'Neil, D., Whitaker, M. J., Tomlinson, J., Storbeck, K-H., Merke, D. P., Ross, R., & Arlt, W. (2016). Modified release and conventional glucocorticoids and diurnal androgen excretion in congenital adrenal hyperplasia. Journal of Clinical Endocrinology and Metabolism, 102(6), 1797-1806. https://doi.org/10.1210/jc.2016-2855
Fleseriu, M., & Karavitaki, N. (2016). Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline. The Journal of clinical endocrinology and metabolism, 101(11), 3888-3921. https://doi.org/10.1210/jc.2016-2118
Nieto, H., & Boelaert, K. (2016). Thyroid stimulating hormone in thyroid cancer: does it matter? Endocrine-related cancer, 23(11), [ERC-16-0328]. https://doi.org/10.1530/ERC-16-0328
Karavitaki, N. (2016). Audit on isolated pituitary stalk lesions/thickening in a tertiary hospital: Comprehensive guidelines needed. Poster session presented at Society for Endocrinology BES 2016, Brighton, United Kingdom. https://doi.org/10.1530/endoabs.44.P83
Essig, G. F., Porter, K., Schneider, D., Arpaia, D., Lindsey, S. C., Busonero, G., Fineberg, D., Fruci, B., Boelaert, K., Smit, J. W., Meijer, J. A. A., Duntas, L. H., Sharma, N., Costante, G., Filetti, S., Sippel, R. S., Biondi, B., Topliss, D. J., Pacini, F., ... Kloos, R. T. (2016). Multifocality in Sporadic Medullary Thyroid Carcinoma: An International Multicenter Study. Thyroid, 26(11), 1563-1572. https://doi.org/10.1089/thy.2016.0255
Arlt, W., & Clinical Committee, S. F. E. (2016). Society for Endocrinology Endocrine Emergency Guidance: Emergency management of acute adrenal insufficiency (adrenal crisis) in adult patients. Endocrine Connections, 5(5), G1-G3. https://doi.org/10.1530/EC-16-0054
Boelaert, K. (2016). WOMEN IN CANCER PROFILE: From bedside to bench and back: my journey in thyroid disease. Endocrine-related cancer, 23(11), 9-13. https://doi.org/10.1530/ERC-16-0396
Sbardella, E., & Karavitaki, N. (2016). A macroprolactinoma becoming resistant to cabergoline and developing atypical pathology. Journal of Clinical and Translational Endocrinology: Case Reports, [16-0038]. https://doi.org/10.1530/EDM-16-0038
O'reilly, M., Reulen, R., Gupta, S., Thompson, C., Dineen, R., Goulden, E., Bugg, G., Pearce, H., Toogood, A., Gittoes, N., Mitchell, R., Thompson, C., & Ayuk, J. (2016). ACTH and gonadotrophin deficiency predict mortality in patients treated for nonfunctioning pituitary adenoma (NFPA): long-term follow-up of 519 patients in two large European centres. Clinical Endocrinology, 85(5), 748–756. https://doi.org/10.1111/cen.13141
Walsh, J., Gittoes, N., & Selby, P. (2016). Emergency management of acute hypercalcaemia in adult patients. Endocrine Connections, 5, G9-G11. https://doi.org/10.1530/EC-16-0055
Johnston, N., Mitchell, R., Haythorne, E., Pessoa, M. P., Semplici, F., Ferrer, J., Piemonti, L., Marchetti, P., Bugliani, M., Bosco, D., Berishvili, E., Duncanson, P., Watkinson, M., Broichhagen, J., Trauner, D., Rutter, G., & Hodson, D. (2016). Beta cell hubs dictate pancreatic islet responses to glucose. Cell Metabolism, 24(3), 389-401. https://doi.org/10.1016/j.cmet.2016.06.020
Wakeling, E., Brioude, F., Lokulo-Sodipe, O., O'Connell, S., Salem, J., Bilek, J., Canton, A., Chrzanowska, K., Davies, J., Dias, R., Dubern, B., Elbracht, M., Giabicani, E., Grimberg, A., Groenskov, K., Hokken-Koelega, A., Jorge, A., Kagami, M., Linglart, A., ... Netchine, I. (2016). Diagnosis and management of Silver–Russell syndrome: first international consensus statement. Nature Reviews Endocrinology. https://doi.org/10.1038/nrendo.2016.138
Chun, R., Hernandez, I., Pereira, R., Swinkles, L., Huijs, T., Zhou, R., Liu, N., Shieh, A., Guemes, M., Mallya, S., Adams, J., & Hewison, M. (2016). Differential responses to vitamin D2 and vitamin d3 are associated with variations in free 25-hydroxyvitamin D. Endocrinology, 157(9), 3420-3430. https://doi.org/10.1210/en.2016-1139
Tampourlou, M., Karavitaki, N., Trifanescu, R., Paluzzi, A., & Ahmed, S. K. (2016). Therapy Of Endocrine Disease: Surgery In Microprolactinomas: Effectiveness And Risks Based On Contemporary Literature. European Journal of Endocrinology, 175(3), R89-96. https://doi.org/10.1530/EJE-16-0087
Larner, D., Morgan, S., Gathercole, L., Doig, C., Guest, P., Weston, C., Hazeldine, J., Tomlinson, J., Stewart, P., & Lavery, G. (2016). Male 11β-HSD1 knockout mice fed trans-fats and fructose are not protected from metabolic syndrome or non-alcoholic fatty liver disease. Endocrinology, 157(9). https://doi.org/10.1210/en.2016-1357
Chan, K. X., Mabbitt, P., Phua, S. Y., Mueller, J. W., Nisar, N., Gigolashvilli, T., Stroeher, E., Grassl, J., Arlt, W., Estavillo, G., Jackson, C., & Pogson, B. (2016). Sensing and signaling of oxidative stress in chloroplasts by inactivation of the SAL1 phosphoadenosine phosphatase. National Academy of Sciences. Proceedings, 113(31), E4567-E4576. https://doi.org/10.1073/pnas.1604936113
Fassnacht, M., Arlt, W., Bancos, I., Dralle, H., Newell-Price, J., Sahdev, A., Tabarin, A., Terzolo, M., Tsagarakis, S., & Dekkers, O. (2016). Management of adrenal incidentalomas - a European Society of Endocrinology Clinical Practice Guideline in collaboration with the European Network for the Study of Adrenal Tumors. European Journal of Endocrinology, 175. https://doi.org/10.1530/EJE-16-0467
Dinnes, J., Bancos, I., Ferrante di Ruffano, L., Chortis, V., Davenport, C., Bayliss, S., Sahdev, A., Guest, P., Fassnacht, M., Deeks, J., & Arlt, W. (2016). Management of endocrine disease: Imaging for the diagnosis of malignancy in incidentally discovered adrenal masses: a systematic review and meta-analysis . European Journal of Endocrinology, 175, R51-R64. https://doi.org/10.1530/EJE-16-0461
Bancos, I., Tamhane, S., Shah, M., Delivanis, D., Alahdab, F., Arlt, W., Fassnacht, M., & Murad, M. H. (2016). The diagnostic performance of adrenal biopsy: a systematic review and meta-analysis. European Journal of Endocrinology, 175, R65-R80. https://doi.org/10.1530/EJE-16-0297
Sanderson, J., James, M. M-S., Stevens, J., Goka, E., Wong, R., Campbell, F., Selby, P., Gittoes, N., & Davis, S. (2016). Clinical effectiveness of bisphosphonates for the prevention of fragility fractures: a systematic review and network meta-analysis. Bone, 89, 52-58. https://doi.org/10.1016/j.bone.2016.05.013
Frank, J., Yushchenko, D., Hodson, D., Lipstein, N., Nagpal, J., Rutter, G., Rhee, J-S., Gottschalk, A., Brose, N., Schultz, C., & Trauner, D. (2016). Photoswitchable diacylglycerols enable optical control of protein kinase C. Nature Chemical Biology, 12, 755-762. https://doi.org/10.1038/nchembio.2141
Clayton, R., Jones, P., Reulen, R., Stewart, P., Hassan-Smith, Z., Ntali, G., Karavitaki, N., Dekkers, O., Pereira, A., Bolland, M., Holdaway, I., & Lindholm, J. (2016). Mortality in patients with Cushing's disease more than 10 years after remission: a multicentre, multinational, retrospective cohort study. The Lancet Diabetes and Endocrinology, 4(7), 569-576. https://doi.org/10.1016/S2213-8587(16)30005-5
El-Gamal, M., Semreen, M., Foster, P., & Potter, B. (2016). Design, synthesis, and biological evaluation of new arylamide derivatives possessing sulfonate or sulfamate moieties as steroid sulfatase enzyme inhibitors. Bioorganic & Medicinal Chemistry, 24(12). https://doi.org/10.1016/j.bmc.2016.04.040
Idkowiak, J., Taylor, A. E., Subtil, S., O'neil, D. M., Vijzelaar, R., Dias, R. P., Amin, R., Barrett, T. G., Shackleton, C. H. L., Kirk, J. M. W., Moss, C., & Arlt, W. (2016). Steroid sulfatase sulfatase deficiency and androgen activation before and after puberty. Journal of Clinical Endocrinology and Metabolism, 101(6), 2545-53. https://doi.org/10.1210/jc.2015-4101
Morgan, S., Hassan-Smith, Z., Doig, C., Sherlock, M., Stewart, P., & Lavery, G. (2016). Glucocorticoids and 11β-HSD1 are major regulators of intramyocellular protein metabolism. Journal of Endocrinology, 229(3), 277-286. https://doi.org/10.1530/JOE-16-0011
Aojula, A., Botfield, H., McAllister, J. P., Gonzalez, A., Abdullah, O., Logan, A., & Sinclair, A. (2016). Diffusion tensor imaging with direct cytopathological validation: characterisation of decorin treatment in experimental juvenile communicating hydrocephalus. Fluids and barriers of the CNS, 13, [9]. https://doi.org/10.1186/s12987-016-0033-2
Ferreira, V., Marcelino, M., Piechnik, S., Marini, C., Karamitsos, T., Ntusi, N., Francis, J., Robson, M., Arnold, R., Mihai, R., Thomas, J., Herincs, M., Hassan-Smith, Z., Greiser, A., Arlt, W., Korbonits, M., Karavitaki, N., Grossman, A., Wass, J., & Neubauer, S. (2016). Pheochromocytoma Is characterized by catecholamine-mediated myocarditis, focal and diffuse myocardial fibrosis, and myocardial dysfunction. Journal of the American College of Cardiology, 67(20), 2364–2374. https://doi.org/10.1016/j.jacc.2016.03.543
Shipman, K., Stammers, J., Doyle, A., & Gittoes, N. (2016). Delivering a quality assured fracture liaison service in a UK teaching hospital – is it achievable? Osteoporosis International. https://doi.org/10.1007/s00198-016-3639-y
Rahman, H-U., Hofland, J., & Foster, P. (2016). In Touch with your Feminine Side: How Oestrogen Metabolism Impacts Prostate Cancer. Endocrine-related cancer. https://doi.org/10.1530/ERC-16-0118
Gathercole, L. L., Hazlehurst, J. M., Armstrong, M. J., Crowley, R., Boocock, S., O'Reilly, M. W., Round, M., Brown, R., Bolton, S., Cramb, R., Newsome, P., Semple, R. K., Paisey, R., Tomlinson, J. W., & Geberhiwot, T. (2016). Advanced non-alcoholic fatty liver disease and adipose tissue fibrosis in patients with Alström syndrome. Liver International. https://doi.org/10.1111/liv.13163
Broichhagen, J., Johnston, N. R., Von Ohlen, Y., Meyer-berg, H., Jones, B. J., Bloom, S. R., Rutter, G. A., Trauner, D., & Hodson, D. J. (2016). Allosteric optical control of a class B G-protein-coupled receptor. Angewandte Chemie (International Edition) , 55(19), 5865–5868. https://doi.org/10.1002/anie.201600957
Kempegowda, P., O'Reilly, M. W., Hassan-Smith, Z., Storbeck, K-H., Taylor, A. E., & Arlt, W. (2016). Impaired DHEA sulfation defines androgen excess in women with polycystic ovarian syndrome (PCOS). Endocrine Abstracts. https://doi.org/10.1530/endoabs.41.GP184
Arlt, W., Torchen, L., Idkowiak, J., Fogel, N., O'Neil, D., Shackleton, C., & Dunaif, A. (2016). Evidence for Increased 5α-Reductase During Early Childhood in Daughters of Women with Polycystic Ovary Syndrome. Journal of Clinical Endocrinology and Metabolism, 101(5), 2069-2075. https://doi.org/10.1210/jc.2015-3926#sthash.9Wp6MrQ4.dpuf
Osterstock, G., Mitutsova, V., Barre, A., Granier, M., Fontanaud, P., Chazalon, M., Carmignac, D., Robinson, I., Low, M., Plesnila, N., Hodson, D., Mollard, P., & Mery, P-F. (2016). Somatostatin triggers rhythmic electrical firing in hypothalamic GHRH neurons. Scientific Reports, 6, [24394 ]. https://doi.org/10.1038/srep24394
Crowley, R. K., & Gittoes, N. J. (2016). Elevated PTH with normal serum calcium level: a structured approach. Clinical Endocrinology. https://doi.org/10.1111/cen.13056
Amin, A. M., Wharton, H., Clarke, M., Syed, A., Dodson, P., & Tahrani, A. A. (2016). The impact of bariatric surgery on retinopathy in patients with type 2 diabetes: A retrospective cohort study. Surgery for Obesity and Related Diseases, 12(3), 606-612. https://doi.org/10.1016/j.soard.2015.08.508
Griffin, A., Parajes, S., Weger, M., Zaucker, A., Taylor, A. E., O'Neil, D. M., Müller, F., & Krone, N. (2016). Ferredoxin 1b (Fdx1b) is the essential mitochondrial redox partner for cortisol biosynthesis in zebrafish. Endocrinology, 157(3). https://doi.org/10.1210/en.2015-1480
Amin, A. M., Wharton, H., Clarke, M., Syed, A., Dodson, P., & Tahrani, A. A. (2016). The impact of bariatric surgery on retinopathy in patients with type 2 diabetes: a retrospective cohort study. Surgery for Obesity and Related Diseases, 12(3), 606-612. https://doi.org/10.1016/j.soard.2015.08.508
Srikanth, P., Chun, R. F., Hewison, M., Adams, J. S., Bouillon, R., Vanderschueren, D., Lane, N., Cawthon, P. M., Dam, T., Barrett-Connor, E., Daniels, L. B., Shikany, J. M., Stefanick, M. L., Cauley, J. A., Orwoll, E. S., Nielson, C. M., & Osteoporotic Fractures in Men (MrOS) Study Research Group (2016). Associations of total and free 25OHD and 1,25(OH)2D with serum markers of inflammation in older men. Osteoporosis International. https://doi.org/10.1007/s00198-016-3537-3
Bornstein, S. R., Allolio, B., Arlt, W., Barthel, A., Don-Wauchope, A., Hammer, G. D., Husebye, E. S., Merke, D. P., Murad, M. H., Stratakis, C. A., & Torpy, D. J. (2016). Diagnosis and treatment of primary adrenal insufficiency: an endocrine society clinical practice guideline. The Journal of clinical endocrinology and metabolism, 101(2), 364-89. https://doi.org/10.1210/jc.2015-1710
Juarez, M., McGettrick, H. M., Scheel-Toellner, D., Yeo, L., Spengler, J., de Paz, B., Hardy, R., Cooper, M., Raza, K., Buckley, C. D., & Filer, A. (2016). DKK1 expression by synovial fibroblasts in very early rheumatoid arthritis associates with lymphocyte adhesion in an in vitro flow co-culture system. Arthritis Research & Therapy, 18(1), [14]. https://doi.org/10.1186/s13075-016-0915-3
Vitlic, A., Lord, J. M., Taylor, A. E., Arlt, W., Bartlett, D. B., Rossi, A., Arora-Duggal, N., Welham, A., Heald, M., Oliver, C., Carroll, D., & Phillips, A. C. (2016). Neutrophil function in young and old caregivers. British Journal of Health Psychology, 21(1), 173-189. https://doi.org/10.1111/bjhp.12156
Hazlehurst, J. M., Oprescu, A. I., Nikolaou, N., Di Guida, R., Grinbergs, A. E. K., Davies, N. P., Flintham, R. B., Armstrong, M. J., Taylor, A. E., Hughes, B. A., Yu, J., Hodson, L., Dunn, W. B., & Tomlinson, J. W. (2016). Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man. The Journal of clinical endocrinology and metabolism, 101(1), 103-113. https://doi.org/10.1210/jc.2015-2928
Doig, C. L., Battaglia, S., Khanim, F. L., Bunce, C. M., & Campbell, M. J. (2016). Knockdown of AKR1C3 exposes a potential epigenetic susceptibility in prostate cancer cells. The Journal of Steroid Biochemistry and Molecular Biology, 155 ( Part A), 47-55. https://doi.org/10.1016/j.jsbmb.2015.09.037
Karavitaki, N. (2016). Craniopharyngiomas: Natural History and Clinical Presentation. In A. Lania, A. Spada, & G. Lasio (Eds.), Diagnosis and Management of Craniopharyngiomas Springer. https://doi.org/10.1007/978-3-319-22297-4_1
Sarkar, S., Hewison, M., Studzinski, G. P., Li, Y. C., & Kalia, V. (2016). Role of vitamin D in cytotoxic T lymphocyte immunity to pathogens and cancer. Critical Reviews in Clinical Laboratory Sciences, 1-14. https://doi.org/10.3109/10408363.2015.1094443
Büttler, R. M., Martens, F., Fanelli, F., Pham, H. T., Kushnir, M. M., Janssen, M. J. W., Owen, L., Taylor, A. E., Soeborg, T., Blankenstein, M. A., & Heijboer, A. C. (2015). Comparison of 7 Published LC-MS/MS Methods for the Simultaneous Measurement of Testosterone, Androstenedione, and Dehydroepiandrosterone in Serum. Clinical Chemistry, 61(12), 1475-83. https://doi.org/10.1373/clinchem.2015.242859
Shaw, G. L., Whitaker, H., Corcoran, M., Dunning, M. J., Luxton, H., Kay, J., Massie, C. E., Miller, J. L., Lamb, A. D., Ross-Adams, H., Russell, R., Nelson, A. W., Eldridge, M. D., Lynch, A. G., Ramos-Montoya, A., Mills, I. G., Taylor, A. E., Arlt, W., Shah, N., ... Neal, D. E. (2015). The Early Effects of Rapid Androgen Deprivation on Human Prostate Cancer. European urology. https://doi.org/10.1016/j.eururo.2015.10.042
Woods, C. P., Argese, N., Chapman, M., Boot, C., Webster, R., Dabhi, V., Grossman, A. B., Toogood, A. A., Arlt, W., Stewart, P. M., Crowley, R. K., & Tomlinson, J. W. (2015). Adrenal suppression in patients taking inhaled glucocorticoids is highly prevalent and management can be guided by morning cortisol. European Journal of Endocrinology, 173(5), 633-42. https://doi.org/10.1530/EJE-15-0608
Mooij, C. F., Parajes, S., Rose, I. T., Taylor, A. E., Bayraktaroglu, T., Wass, J. A. H., Connell, J. M. C., Ray, D. W., Arlt, W., & Krone, N. (2015). Characterization of the molecular genetic pathology in patients with 11β-hydroxylase deficiency. Clinical Endocrinology, 83(5), 629-635. https://doi.org/10.1111/cen.12834
Read, M., Fong, J., Imruetaicharoenchoke, W., Modasia, B., Lewy, G., Ryan, G., Sharma, N., Smith, V., Watkinson, J., Boelaert, K., & McCabe, C. (2015). Distinct p53 response profiles in transgenic mouse models of thyroid-specific PBF and PTTG expression. Endocrine Abstracts, 38, [P149]. https://doi.org/10.1530/endoabs.38.P149
Read, M., Smith, J., Smith, V., Bosseboeuf, E., Wake, N., Watkinson, J., Wallis, Y., Maher, E., McCabe, C., & Woodward, E. (2015). Functional consequences of germline mutations in a novel non-RET medullary thyroid cancer susceptibility gene. Endocrine Abstracts, 38, [OC5.1]. https://doi.org/10.1530/endoabs.38.OC5.1
Sherlock, M., Behan, L. A., Hannon, M. J., Alonso, A. A., Thompson, C. J., Murray, R. D., Crabtree, N., Hughes, B. A., Arlt, W., Agha, A., Toogood, A. A., & Stewart, P. M. (2015). The modulation of corticosteroid metabolism by hydrocortisone therapy in patients with hypopituitarism increases tissue glucocorticoid exposure. European Journal of Endocrinology, 173(5), 583-93. https://doi.org/10.1530/EJE-15-0490
Dar, S., Tahrani, A. A., & Piya, M. K. (2015). The role of GLP-1 receptor agonists as weight loss agents in patients with and without type 2 diabetes. Practical Diabetes, 32(8), 297-300b. https://doi.org/10.1002/pdi.1978
Hodson, L., Banerjee, R., Rial, B., Arlt, W., Adiels, M., Boren, J., Marinou, K., Fisher, C., Mostad, I. L., Stratton, I. M., Barrett, P. H. R., Chan, D. C., Watts, G. F., Harnden, K., Karpe, F., & Fielding, B. A. (2015). Menopausal Status and Abdominal Obesity Are Significant Determinants of Hepatic Lipid Metabolism in Women. Journal of the American Heart Association, 4(10), [e002258]. https://doi.org/10.1161/JAHA.115.002258
Kempegowda, P., O'Reilly, M. W., Crabtree, N. J., Taylor, A. E., Hughes, B. A., Tomlinson, J. W., & Arlt, W. (2015). Visceral fat drives 5[alpha]-reductase activity independent of BMI in women with polycystic ovarian syndrome. Endocrine Abstracts. https://doi.org/10.1530/endoabs.38.P356
O'Reilly, M., Kempegowda, P., Botfield, H., Ali, F., Taylor, A., Hughes, B., Tomlinson, J., Arlt, W., & Sinclair, A. (2015). Women with idiopathic intracranial hypertension have a distinct andro-metabolic signature compared to polycystic ovary syndrome and simple obesity. Endocrine Abstracts. https://doi.org/10.1530/endoabs.38.P193
Mueller, J. W., Gilligan, L. C., Idkowiak, J., Arlt, W., & Foster, P. A. (2015). The Regulation of Steroid Action by Sulfation and Desulfation. Endocrine Reviews, 36(5), 526-563. https://doi.org/10.1210/er.2015-1036
Stengel, C., Newman, S. P., Leese, M. P., Thomas, M. P., Potter, B. V. L., Reed, M. J., Purohit, A., & Foster, P. A. (2015). The in vitro and in vivo activity of the microtubule disruptor STX140 Is mediated by Hif-1 alpha and CAIX expression. Anticancer research, 35(10), 5249-5261. https://ar.iiarjournals.org/content/35/10/5249
Daniel, E., Aylwin, S., Mustafa, O., Ball, S., Munir, A., Boelaert, K., Chortis, V., Cuthbertson, D. J., Daousi, C., Rajeev, S. P., Davis, J., Cheer, K., Drake, W., Gunganah, K., Grossman, A., Gurnell, M., Powlson, A. S., Karavitaki, N., Huguet, I., ... Newell-Price, J. (2015). Effectiveness of metyrapone in treating Cushing's Syndrome: a retrospective multicenter study in 195 patients. The Journal of clinical endocrinology and metabolism, 100(11), [jc20152616]. https://doi.org/10.1210/jc.2015-2616
Ahmed, S. F., Achermann, J. C., Arlt, W., Balen, A., Conway, G., Edwards, Z., Elford, S., Hughes, I. A., Izatt, L., Krone, N., Miles, H., O'Toole, S., Perry, L., Sanders, C., Simmonds, M., Watt, A., & Willis, D. (2015). Society for Endocrinology UK guidance on the initial evaluation of an infant or an adolescent with a suspected disorder of sex development (Revised 2015). Clinical Endocrinology. https://doi.org/10.1111/cen.12857
Taylor, A. E., Keevil, B., & Huhtaniemi, I. T. (2015). Mass spectrometry and immunoassay: how to measure steroid hormones today and tomorrow. European Journal of Endocrinology, 173(2), D1-12. https://doi.org/10.1530/EJE-15-0338
Capatina, C., Paluzzi, A., Mitchell, R., & Karavitaki, N. (2015). Diabetes insipidus after traumatic brain injury. Journal of Clinical Medicine, 4(7), 1448-62. https://doi.org/10.3390/jcm4071448
Hassan-Smith, Z. K., Morgan, S. A., Sherlock, M., Hughes, B., Taylor, A. E., Lavery, G. G., Tomlinson, J. W., & Stewart, P. M. (2015). Gender-specific differences in skeletal muscle 11β-HSD1 expression across healthy aging. The Journal of clinical endocrinology and metabolism, 100(7), 2673-2681. https://doi.org/10.1210/jc.2015-1516
Mooij, C. F., Parajes, S., Pijnenburg-Kleizen, K. J., Arlt, W., Krone, N., & Claahsen-van der Grinten, H. L. (2015). Influence of 17-Hydroxyprogesterone, Progesterone and Sex Steroids on Mineralocorticoid Receptor Transactivation in Congenital Adrenal Hyperplasia. Hormone research in paediatrics, 83(6), 414-421. https://doi.org/10.1159/000374112
Ho, S. C., Clayton, P., Vasudevan, P., Greening, J., Wardhaugh, B., Shaw, N., Kelnar, C., Kirk, J., & Högler, W. (2015). Recombinant Human Growth Hormone Therapy in Children with Chromosome 15q26 Deletion. Hormone Research in Paediatrics, 83(6), 424-430. https://doi.org/10.1159/000380949

Connecting Cultures

Life-Changing Technologies

Thriving Planet

Global Health

Fairer World

Explore our Spotlights

CEDAM publications

Culture and collections

Schools, institutes and departments

College of Arts and Law

College of Medical and Dental Sciences

College of Life and Environmental Sciences

College of Engineering and Physical Sciences

College of Social Sciences

See all schools, departments, research and professional services

Services and facilities