Birmingham has amongst the highest rates of diabetes and obesity in the UK. The Diabetes and Obesity Group comprises a number of investigators who contribute to treatment, NHS guidelines, policy making, training and education and ultimately patient care through their basic and clinical research under the CEDAM umbrella.
Active areas of study include:
- Sleep disorders and metabolic disease;
- Exercise, immunotherapy and type 1 diabetes;
- Rare childhood diabetes syndromes and type 2 diabetes in children;
- Adipocyte dysfunction and obesity;
- Stress hormones and diabetes risk;
- Beta cell regeneration;
- Population-based studies in diabetes and obesity;
- Obesity management and health care delivery;
- The pharmacology of diabetes and obesity,
- The epidemiology, pathogenesis and treatment of diabetes-related microvascular complications, particularly neuropathy and nephropathy.
Work is supported through access to large public health databases, the Birmingham NIHR/Wellcome Trust Clinical Research Facility, the Birmingham Clinical Trials Unit (BCTU), as well as next generation sequencing, super-resolution imaging and drug screening platforms, the latter via interactions with the Centre for Membrane and Protein Receptors (COMPARE), Institute of Metabolism and Systems Research (IMSR) and Institute of Applied Health Research (IAHR).
Patient recruitment to basic science and clinical research trials is supported through close collaboration across the six main hospitals in Birmingham (including Birmingham Children’s Hospital, the largest diabetes service in the UK) and through colleagues in primary care via the clinical research networks.
Training of clinical and basic scientists in diabetes and obesity is supported through the academic foundation and NIHR Clinical fellows programme.
The diabetes unit at Birmingham children’s hospital recruits to the UK Immunotherapy in type 1 diabetes consortium, and international initiatives such as the EU-IMI funded INNODIA project and the European Reference Networks for Rare Diseases.
A wide range of education courses are led from Birmingham, including annual meetings in obesity and diabetic neuropathy as well as twice yearly Midland Endocrine and Diabetes Club (MEDC) meetings