Kreft Lab

Social behaviour, biofilms, and the importance of being spatial

The Kreft Lab, led by Dr Jan-Ulrich Kreft, focuses on the dynamics of microbial interactions and spatial structure in microbial communities, particularly in biofilms and the gut microbiota, using a combination of experimental and computational approaches.

Questions we like to ask in Kraft Lab are:

  • How are resistance plasmids maintained in the environment?
  • How does prey size affect the bacterial predator Bdellovibrio bacteriovorus?
  • Why is metabolic labour divided in nitrification?
  • How can cooperation as restraint from competition or the economical use of resources evolve (tragedy of the commons)?
  • What is the fitness advantage of the division of labour between motile and immotile subpopulations of Pseudomonas aeruginosa?
  • Is quorum sensing really just measuring cell density under more complex natural conditions, e.g. when cells are clustered?
  • What are the advantages and disadvantages of broad and narrow host range plasmids (generalists versus specialists)?
  • What is the optimal gut layout and gut microbiota community composition for the energy intake of the host?
  • How important is spatial heterogeneity of microbes and patchiness of resource distribution for the degradation of pollutants in groundwater ecosystems?

To address these fundamental questions we combine individual-based modelling and other mathematical models with experiments in the laboratory.

Members of the group

Current members

  • Dr Jan-Ulrich Kreft
  • Anjali Vasudevan (2021-2025)
  • Emmanuel Gideon Idu (2025-2028)

Former group members

  • Dr Cansu Uluseker (2021-2024)
  • Dr Timothy Foster (2018-2021)
  • Dr Roberto de la Cruz (2018-2020)
  • Dr Eleni Cristidi (2017-2022)
  • Dr Kim Summers (2016-2019)
  • Dr Kieran Alden (2013-2014)
  • Ozcan Gazioglu (2013-2015)
  • Dr Feng Dong (2012-2016)
  • Dr Robert J Clegg (2010-2016)
  • Dr Susanne I Schmidt (2009-2011)
  • Dr Sonia Martins (2008-2012)
  • Chinmay Kanchi (2008-2012)
  • Example biofilm with two different bacteria and smaller EPS particles produced by the bacteria.

    iDynoMICS

    iDynoMiCS 2.0, short for individual-based Dynamics of Microbial Communities Simulator 2.0, is an advanced software platform designed to model and simulate microbial communities, such as biofilms, at the individual level.

    Find out more
  • Gut Flora Microflora Microbiota Bacteria Microbe in a healthy gut

    eGUT - the Electronic Gut

    The computer simulation tool eGUT, models the molecular interactions in the microbiota, validating observed results for a particular application against observed behaviours

    Explore eGUT

Research Themes

The focus of our research has revolved around Individual-based Modelling but we have also used other mathematical models for comparison and in cases where simpler models are more appropriate. Experimental validation is the second branch of our activities.

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