Research

CPROR is working with international collaborators to develop best practice for PROs in clinical trials.  This includes the selection of PROs, trial design (including the development of a SPIRIT-PRO extension), minimising missing data, managing PRO Alerts and the transparent reporting of PRO data (using CONSORT-PRO) to maximise impact and patient benefit. 

Current projects:

EPiC: Evaluation of Patient-Reported Outcome (PRO) Protocol Content and Reporting in UK Cancer Clinical Trials

SPIRIT-PRO Standard Protocol Items: Recommendations for Interventional Trials Patient-Reported Outcome Extension

PRO-IMPACT Impact of PRO trial data on health policy and clinical practice

PARTNERS: Collaborative care for people with serious mental illness (Core Outcome Set Development)

Techniques to include carers' quality of life in economic evaluation

Assessing Impact and Directing treatment in patients with Uveitic Macular Oedema (AID UMO) Study

IMPRESS-AF: IMproved exercise tolerance in heart failure with PReserved Ejection fraction by Spironolactone on myocardial fibrosiS in Atrial Fibrillation

RePROM: The use of an electronic Patient-Reported Outcome Measure in the Management of Patients with Advanced Chronic Kidney Disease (CKD)

CPROR members provide methodological expertise across a range of applied health research including:

PRO-CAR-T™ Study

CAR-T therapy is a new approach to cancer treatment in which the body's own immune cells are modified to recognise and kill off cancer cells. CAR-T therapy is promising but the side effects of treatment can be serious. It is important to catch side effects early so people can receive medicines to help treat them. One way of monitoring side effects is to ask patients to report their symptoms. Digital tools to assess CAR-T patients’ symptoms are not yet widely available.  We are conducting the PRO-CAR-T™ research study to develop and test a new digital tool specifically designed to collect patients’ symptom and quality of life data reports following CAR-T therapy.

This work is funded by the NIHR Blood and Transplant Research Unit in Precision and Cellular Therapeutics. For further information please contact: btru@contacts.bham.ac.uk

Bluebelle: a feasibility study of three wound dressing strategies in eLective and unplanned surgery

Pegasus: the feasibility of a full-scale open trial of the effectiveness and cost-effectiveness of pressure garments

Missed Opportunities To Prevent Stroke And Residual Impairments After Transient Ischaemic Attack (TIA)

Optimising rate-control therapy in older patients with AF– a training fellowship and pilot study focused on improving quality of life

NOAH: Non-vitamin K antagonist Oral anticoagulants in patients with Atrial High rate episodes

RATE-AF: Optimising rate-control therapy in older patients with AF– a training fellowship and pilot study focused on improving quality of life

SUPPORT TIA: Structured follow-Up Pathway to imProve management Of Residual impairmenTs and patients’ quality of life after TIA and minor stroke. Development and feasibility testing of a care pathway that will help manage long-term problems after mini-stroke

PRiORiTy: Patient Reported Outcomes Research in Trauma. Developing a pathway for the electronic capture of PROMs/PREMs for inclusion within the SRMRC clinical information platform for use in research and routine and ongoing clinical care

International research in cancer has shown that ePROs can:

• Improve communication between patients and doctors, helping shared decision-making
• Improve patient quality of life
• Reduce the risk of hospital admission
• Increase patient survival 

CPROR members are leading research to develop ePRO systems that tailor care to individual patient needs, improve care and outcomes including:

• PROCEED: Patient Reported OutComEs in rarE Disease
• PRO-trACK: Using Patient-Reported Outcome measures (PROMs) to promote quality of care and safety in the management of patients with Advanced Chronic Kidney Disease
• RCAT (Renal Computerised Adaptive Test): developing a novel item bank and computerised adaptive test for symptom tracking in patients with chronic kidney disease