RMS 2005

A protocol for non metastatic rhabdomyosarcoma.
(Incorporates EpSSG-RMS-MET 2008: Treatment Arm for Metastatic Disease)

Trial Overview and Summary

 Chief Investigator (UK): Dr Meriel Jenney 
 Sponsor (UK): University of Birmingham 
 Funder: Cancer Research UK (Trial Number CRUK/06/027) 
 Disease Site: Rhabdomyosarcoma 
 Trial Type: Clincial Trial of an Investigational Medicinal Product 
 Status:  Closed to recruitment
 UKCRN Study ID (if applicable): 2247 
 ClinicalTrials.gov identifier: NCT00379457 
 Open to New Sites? No 
 Recruitment Start Date: May 2006 
 Anticipated Recruitment End Date: December 2016 
 CRCTU Trial Management Team: Children's Cancer Trials Team 
 Trial Email Address: RMS2005@trials.bham.ac.uk 

A plain English summary of this trial can be found at on the Cancer Help website (see Other Websites below for the link)

The RMS 2005 trial is for children and young people who have rhabdomyosarcoma which is a cancer affecting muscle and soft tissue. There are different types of rhabdomyosarcoma some of which can be more difficult to treat. Children in the RMS 2005 trial receive treatment depending on their age; where the tumour is located; the size of the tumour and the type of rhabdomyosarcoma.

One of the aims of the trial is to see whether it is beneficial to give additional chemotherapy to children who have tumours which are more difficult to treat. These patients are randomly allocated to two groups: one group does not receive any further chemotherapy whilst the other group receives a further 6 months of ‘maintenance’ chemotherapy.  This is relatively low dose chemotherapy that can be given as an outpatient. By following the two groups of patients doctors will be able to see whether the additional chemotherapy improves the outcome for these children or whether it just adds a greater burden of treatment with extra visits to the hospital with no difference in survival.

Please note that the trials team cannot give individual’s clinical advice. Patients and their families should contact their treating physician to discuss trials for which they may be eligible.

Trial Summary

  • View Trial Summary Document

Trial Protocol

  • View Trial Protocol Document

Please Note:
Clinical trial protocols are complex technical documents which should only be used for the treatment of subjects taking part in the trial. Patients who are interested in taking part in the trial are advised to talk to their health care professional.
Investigators please ensure you have R&D approval for this specific version of the protocol before using as a reference. 

More information