TEAM: An open label randomised multicentre comparative trial of 5 years adjuvant exemestane treatment versus adjuvant tamoxifen followed by exemestane in postmenopausal women with early stage breast cancer
 Chief Investigator:
 Dr Daniel Rea
 Sponsor:  University of Birmingham
 Funder:  Pfizer
Disease Site:   Breast Cancer
 Trial Type:   Clincial Trial of an Investigational Medicinal Product
 Status:  In Follow-up
 UKCRN Study ID (if applicable): 2004218974GB
 ISRCTN Referance Number:  75225940
 Open to New Sites?  No
 Recruitment Start Date: 05-Dec-2001
 Recruitment End Date: 07-Oct-2005
 CRCTU Trial Management Team:  Late Phase Trial Management Team- B
 Trial Email Address:

Trial Summary

The TEAM trial was designed in 2000/2001 and was originally designed to compare tamoxifen for 5 years with exemestane for 5 years in postmenopausal women with early breast cancer. A large body of information regarding third-generation aromatase inhibitors in early breast cancer emerged and in particular data was published following the start of recruitment, which demonstrated a clear Relapse Free Survival (RFS) advantage to a sequential strategy in which exemestane is introduced after 2-3 years of prior tamoxifen. As a result of this data an amendment to the trial design was introduced in which patients originally randomised to tamoxifen were recommended to switch to exemestane after 2.5-3 years of tamoxifen therapy. All patients, regardless of whether or not they switched treatment, were followed up for 10 years.

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Trial Protocol

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Clinical trial protocols are complex technical documents which should only be used for the treatment of subjects taking part in the trial.
Investigators please ensure you have R&D approval for this specific version of the protocol before using as a reference. 

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