Cell recruitment into the liver – causes, consequences and potentials as therapy

Group leader: Dr Patricia Lalor

Overview

Dr Lalor’s group are working to understand the mechanisms that underpin inflammatory and metabolic liver diseases. A particular emphasis is placed upon understanding the biology of hepatic sinusoidal endothelial cells and how recruitment of platelets into the liver parenchyma has diverse and often opposing consequences for acute and chronic conditions. We are also using novel NMR-based metabolomics analyses to understand the metabolic picture in cirrhosis and how specific cellular components contribute to this. We also work closely with Prof Newsome to investigate recruitment of progenitor cells into the diseased liver

Our research group

Group Members

Dr Elizabeth Hepburn,

Dr Abishek Chauhan, Clinical Research Fellow

Raquel Saborano

Publications

Chauhan A, Adams DH, Watson SP and Lalor PF (2016) Platelets: No longer bystanders in liver disease. Hepatology 64(5):1774-1784

Chen YY, Jeffery HC, Hunter S, Bhogal R, Birtwistle J, Braitch MK, Roberts S, Ming M, Hannah J, Thomas C, Adali G, Hübscher SG, Syn WK, Afford S, Lalor PF, Adams DH and Oo YH (2016) Human intrahepatic regulatory T cells are functional, require IL-2 from effector cells for survival, and are susceptible to Fas ligand-mediated apoptosis. Hepatology 64(1):138-50

Karim S, Liaskou E, Fear J, Garg A, Reynolds G, Claridge L, Adams DH, Newsome PN and Lalor PF (2014) Dysregulated hepatic expression of glucose transporters in chronic disease: contribution of semicarbazide-sensitive amine oxidase to hepatic glucose uptake. Am J Physiol Gastrointest Liver Physiol 307(12):G1180-90

Griffiths RL, Sarsby J, Guggenheim EJ, Race AM, Steven RT, Fear J, Lalor PF and Bunch J (2013) Formal lithium fixation improves direct analysis of lipids in tissue by mass spectrometry. Anal Chem 85(15):7146-53. doi: 10.1021/ac400737z