The role of the inflammatory microenvironment in liver fibrosis and cancer

Group leader: Dr Shishir Shetty


Shishir's group is studying the role of the innate and adaptive immune system in mediating liver fibrosis and carcinogenesis.  The research focus is on the regulation of leucocyte recruitment to the liver and the role of novel adhesion molecules including scavenger receptors. He is also studying how scavenger receptors influence the tissue microenvironment in fibrosis and cancer. The overall aim is to identify new targets of therapy for inflammatory liver disease and primary liver cancer.cever2

Our research group

Group Members

Daniel Patten, Post Doctoral Fellow

Vandana Sagar, Clinical Fellow

Owen Cain, Clinical Fellow


Patten DA, Wilson GK, Bailey D, Shaw RK, Jalkanen S, Salmi M, Rot A, Weston CJ, Adams DH and Shetty S (2016) Human liver sinusoidal endothelial cells promote intracellular crawling of lymphocytes during recruitment- a new step in migration. Hepatology [Epub ahead of print]

Than NN, Ghazanfar A, Hodson J, Tehami N, Coldham C, Hodson J, Mergental H, Shah T, Manas D, Newsome PN, Reeves H and Shetty S (2016) Comparing clinical presentations, treatments and outcomes of hepatocellular carcinoma due to hepatitis C and non-alcoholic fatty liver disease. QJM [Epub ahead of print]

Hoare M, Ito Y, Kang T, Weekes M, Matheson MJ, Patten DA, Shetty S,  Parry AJ, Menon S, Salama R, Antrobus R, Tomimatsu K, Howat W, Lehner PJ, Zender L and Narita M (2016) NOTCH-1 mediates a switch between two distinct secretomes during senescence. Nat Cell Biol 18(9):979-92

Rantakari P*, Patten DA*, Valtonen J, Karikoski M, Gerke H, Dawes H, Laurila J,  Ohlmeier S, Elima K, Hubscher SG, Weston CJ, Jalkanen S, Adams DH, Salmi M and Shetty S (2016) Stabilin-1expression defines a subset of macrophages which mediate tissue homeostasis and prevent fibrosis in chronic liver injury. Proc Natl Acad Sci U S A 113(33):9298-303
* denotes joint authorship