About the research
Pituitary tumour research focuses on hypothalamo-pituitary disease including pituitary and other sellar/parasellar tumours, hypothalamic dysfunction and the consequences of pituitary tumour treatment including hypopituitarism, employing clinical and translational approaches (Karavitaki). We are particularly interested in the identification of biomarkers of diagnostic, prognostic and therapeutic significance; systemic biobanking of patients and detailed phenotyping facilitate these aims (Birmingham Pituitary Biobank). In collaborative studies, we look at the pathogenesis of craniopharyngiomas and pituitary adenomas, long-term outcomes of various management approaches and prognostic parameters. Novel treatments for pituitary tumours and relevant clinical trials are further areas of our work.
Atila C, Loughrey PB, Garrahy A, Winzeler B, Refardt J, Gildroy P, Hamza M, Pal A, Verbalis JG, Thompson CJ, Hemkens LG, Hunter SJ, Sherlock M, Levy MJ, Karavitaki N, Newell-Price J, Wass JAH, Christ-Crain M. Central diabetes insipidus from a patient's perspective: management, psychological co- morbidities, and renaming of the condition: results from an international web- based survey. Lancet Diabetes Endocrinol. 2022 Oct;10(10):700-709. doi: 10.1016/S2213-8587(22)00219-4. Epub 2022 Aug 22. PMID: 36007536.
Hamblin R, Vardon A, Akpalu J, Tampourlou M, Spiliotis I, Sbardella E, Lynch J, Shankaran V, Mavilakandy A, Gagliardi I, Meade S, Hobbs C, Cameron A, Levy MJ, Ayuk J, Grossman A, Ambrosio MR, Zatelli MC, Reddy N, Bradley K, Murray RD, Pal A, Karavitaki N. Risk of second brain tumour after radiotherapy for pituitary adenoma or craniopharyngioma: a retrospective, multicentre, cohort study of 3679 patients with long-term imaging surveillance. Lancet Diabetes Endocrinol. 2022 Aug;10(8):581-588. doi: 10.1016/S2213-8587(22)00160-7. Epub 2022 Jul 1. PMID: 35780804.
Fountas A, Van Uum S, Karavitaki N. Opioid-induced endocrinopathies. Lancet Diabetes Endocrinol. 2020 Jan;8(1):68-80. doi: 10.1016/S2213-8587(19)30254-2. Epub 2019 Oct 14. PMID: 31624023.