About the research
The Energy Metabolism theme defines mechanisms relating to the control of energy metabolism in mammalian physiology and complex disease, employing molecular, cellular and both animal-based and human in vivo physiology approaches including nutritional and nutriceutical interventions. The IMSR Mouse Metabolic Phenotyping core enables deep metabolic phenotyping of animal models to understand how energy-sensors in muscle, liver and brain influence glucose homeostasis (da Silva Xavier), how NAD+ biology influences muscle ageing (Lavery) and how nutrients partition in islet beta and alpha cells to influence insulin and glucagon secretion (Hodson). Hodson (ERC Starter) uses advanced imaging, chemical biology, chemogenetics and CRISPR-Cas9 genome-editing to understand how different cell subpopulations contribute to islet function. Akerman uses genomics and bioinformatics to identify new diabetes susceptibility regions of the human genome. IMSR-affiliated investigators from Sports, Exercise and Rehabilitation Sciences collaborate on exercise metabolism and nutrition (Breen, Lai, Wallis, Whitham).
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. Elhassan YS, Kluckova K, Fletcher RS, Schmidt MS, Garten A, Doig CL, Cartwright DM, Oakey L, Burley CV, Jenkinson N, Wilson M, Lucas SJE, Akerman I, Seabright A, Lai YC, Tennant DA, Nightingale P, Wallis GA, Manolopoulos KN, Brenner C, Philp A, Lavery GG. Cell Rep. 2019 Aug 13;28(7):1717-1728.e6.
Neuronatin regulates pancreatic β cell insulin content and secretion. Millership SJ, Da Silva Xavier G, Choudhury AI, Bertazzo S, Chabosseau P, Pedroni SM, Irvine EE, Montoya A, Faull P, Taylor WR, Kerr-Conte J, Pattou F, Ferrer J, Christian M, John RM, Latreille M, Liu M, Rutter GA, Scott J, Withers DJ. J Clin Invest. 2018 Aug 1;128(8):3369-3381.
Glucocorticoids Reprogram β-Cell Signaling to Preserve Insulin Secretion Fine NHF, Doig CL, Elhassan YS, Vierra NC, Marchetti P, Bugliani M, Nano R, Piemonti L, Rutter GA, Jacobson DA, Lavery GG Hodson DJ. Diabetes. 2018 Feb;67(2):278-290. doi: 10.2337/db16-1356. Epub 2017 Dec 4.