About the research
The Diabetes and Energy Metabolism theme employs molecular, cellular and in vivo physiology approaches to define mechanisms relating to the control of metabolism in disease. The IMSR Mouse Metabolic Phenotyping core enables deep metabolic phenotyping of animal models to understand how energy-sensors in muscle, liver and brain influence glucose homeostasis (da Silva Xavier), how NAD+ biology influences muscle ageing (Lavery) and how nutrients partition in islet beta and alpha cells to influence insulin and glucagon secretion (Hodson). Hodson (ERC Starter) uses advanced imaging, chemical biology and CRISPR-Cas9 genome-editing to understand how different cell subpopulations contribute to islet function. Gorvin (AMS Starter Grant) investigates the regulation of GPCRs involved in food intake and obesity using novel screening approaches. Akerman (Diabetes UK RD Lawrence Fellow) uses genomics and bioinformatics to identify new diabetes susceptibility regions of the human genome. Prete (Diabetes UK Sir George Alberti Fellow) investigates the mechanisms underlying the increased type 2 diabetes risk in patients with mild autonomous cortisol excess due to adrenal adenomas. Arlt (Wellcome Trust Investigator) studies how lipid metabolism and diabetes risk is influenced by androgen excess in women with polycystic ovarian syndrome. Thangaratinam (NIHR) investigates how maternal obesity and diabetes impacts lifelong metabolic health of the offspring. IMSR-affiliated investigators from Sports, Exercise and Rehabilitation Sciences collaborate on exercise metabolism and nutrition (Breen, Lai, Wallis, Whitham).
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. Elhassan YS, Kluckova K, Fletcher RS, Schmidt MS, Garten A, Doig CL, Cartwright DM, Oakey L, Burley CV, Jenkinson N, Wilson M, Lucas SJE, Akerman I, Seabright A, Lai YC, Tennant DA, Nightingale P, Wallis GA, Manolopoulos KN, Brenner C, Philp A, Lavery GG. Cell Rep. 2019 Aug 13;28(7):1717-1728.e6.
Neuronatin regulates pancreatic β cell insulin content and secretion. Millership SJ, Da Silva Xavier G, Choudhury AI, Bertazzo S, Chabosseau P, Pedroni SM, Irvine EE, Montoya A, Faull P, Taylor WR, Kerr-Conte J, Pattou F, Ferrer J, Christian M, John RM, Latreille M, Liu M, Rutter GA, Scott J, Withers DJ. J Clin Invest. 2018 Aug 1;128(8):3369-3381.
Glucocorticoids Reprogram β-Cell Signaling to Preserve Insulin Secretion Fine NHF, Doig CL, Elhassan YS, Vierra NC, Marchetti P, Bugliani M, Nano R, Piemonti L, Rutter GA, Jacobson DA, Lavery GG Hodson DJ. Diabetes. 2018 Feb;67(2):278-290. doi: 10.2337/db16-1356. Epub 2017 Dec 4.