Our research aims to understand the mechanisms that regulate recruitment of leukocytes into inflamed tissues during protective resolving responses, and how these processes go wrong in chronic inflammatory and auto-immune diseases. We have described new pathways which regulate migration of leukocytes into tissue through the endothelial cells which line blood vessels, and the roles of local flow and of the surrounding tissue in defining normal or pathological inflammatory responses.
Professor of Inflammation and Vascular Biology
Staff profile for Professor Helen McGettrick, Professor of Inflammation and Vascular Biology, Department of Inflammation and Ageing, College of Medicine and Health, the University of Birmingham
Deputy Director of the Department of Cardiovascular Sciences
Staff profile for Professor Ed Rainger, Deputy Director of the Department of Cardiovascular Sciences, Director of Research and Professor of Chronic Inflammation.
Professor of Inflammation Biology
Staff profile of Dr Asif Iqbal, Professor of Inflammation Biology, at Cardiovascular Sciences, University of Birmingham
Honorary Senior Research Fellow
Staff profile of Dr Myriam Chimen, Department of Inflammation and Ageing, College of Medicine and Health, The University of Birmingham.
The Group Leads work in a highly collaborative manner with over-lapping projects, using in vitro and in vivo models for studying a variety of factors that influence leukocyte trafficking. In vitro models of the vasculature allow us to visualise the effects of blood flow on the behaviour of endothelial cells, and on the recruitment of leukocytes, platelets and stem cells.
We have also developed sophisticated co-culture models to examine how platelets, monocytes or stromal cells (e.g. fibroblasts, mesenchymal stem cells) regulate the delivery of leukocytes to foci of disease. More recently, we have extended this concept using integrated 3-D multi-cellular models which allow us to track leukocytes through layers of primary human cells and determine their behaviour and ultimately their fate. To complement this work we use transgenic and preclinical models of disease, along with intravital microscopy, to further dissect these processes in vivo and elucidate mechanisms and potential therapeutic targets.
View our research featured in a University of Birmingham news release.
Latest press release - http://www.birmingham.ac.uk/news/latest/2015/04/Newly-discovered-pathway-200415.aspx
For full publication lists see:
Professor Ed Rainger
Dr Helen McGettrick
Dr Myriam Chimen
Professor Asif Iqbal
Dr Matt Harrison
Dr Sahithi Kuravi
Dr Lozan Sheriff
Nichola Adlard
Bonita Apta
Hafsa Munir
Jasmeet Reyat
Lewis Clarke
Aigli Evryviadou
Professor Roy Bicknell
Professor Andrew Bradbury
Professor Chris Buckley
Dr Jorge Caamano
Professor Adam Cunningham
Professor Andrew Filer
Professor Jon Frampton
Dr Paul Harrison
Dr Victoria Heath
Dr Peter Hewett
Dr Nick Jones
Dr Neena Kalia
Professor Patricia (Trish) Lalor
Dr Melanie Madhani
Dr Ashley Martin
Professor Paul Murray
Professor Parth Narendran
Professor Phil Newsome
Professor Karim Raza
Dr Yotis Senis
Professor David Thickett
Dr Mike Tomlinson
Professor Steve Watson
Professor Mark Wheatley
Dr Steve Young
Professor Paul Moss
Dr Warwick Dunn
Dr Shan He
Surgeon Captain Mark Midwinter- Centre for Defence Medicine, University Hospitals Birmingham NHS Trust, UK
Mr Naiem Moiemen- Midlands Burn Network, University Hospitals Birmingham NHS Trust, UK
Mr Alok Tiwari - Birmingham Vascular Clinics, University Hospitals Birmingham NHS Trust, UK
Professor Philip Calder - University of Southampton
Professor Andrew Dick - University of Bristol
Professor Stuart Egginton - University of Leeds
Professor Lucy Walker - University College London
Dr Jim Middleton - University of Bristol
Professor Nick Morrell - University of Cambridge
Professor Sussan Nourshargh - Barts and The London School of Medicine and Dentistry
Professor Valerie O’Donnell - Cardiff University
Professor Susan Wong - Cardiff University
