preps logoVaginal Preparation at Caesarean Section to Reduce Endometritis and Prevent Sepsis – A Feasibility Study of Chlorhexidine

 Main Trial Features

  • A feasibility randomised controlled trial of vaginal cleansing at caesarean section (CS) with chlorhexidine gluconate or acetate compared to no cleansing, including a qualitative aspect to develop women centred outcomes of wellbeing after delivery.
  • Funded by the NIHR Research for Patient Benefit (RfPB) PB-PG-1215-20013
  • Chief Investigator Dr Katie Morris
  • Coordinated by Birmingham Clinical Trials Unit (BCTU)
  • Sponsored by Birmingham Women's and Children's NHS Foundation Trust

The PREPS feasibility study is now closed for recruitment and results are being prepared for publication. Please contact us at if you have any questions.


 PREPS Protocol V2.0


Hodgetts Morton, V., Wilson, A., Hewitt, C., Weckesser, A., Farmer, N., Lissauer, D., Hardy, P. and Morris, R.K. 2018.  Chlorhexidine vaginal preparation versus standard treatment at caesarean section to reduce endometritis and prevent sepsis—a feasibility study protocol (the PREPS trial). Pilot and Feasibility Studies 4:84