RNA biology

rna-biology-headerSaverio group’s research is interested in understanding what ribosomes do in the cell nucleus. Yes, there are functional ribosomes in the nucleus. We and others have found direct evidence of this in Drosophila cells (see our publications). We now want to understand what these ribosomes do. We suspect that they play a  role in gene expression and nuclear mRNA processing in particular, including playing a role in nonsense-mediated mRNA decay (NMD): a conserved eukaryotic phenomenon without a satisfactory mechanism yet. We research these topics in yeast, mostly S. pombe, as well as Drosophila.

Principal Investigator