AdUP Trial: For Investigators

AdUP: A Phase I Clinical Trial of a replication defective type 5 adenovirus vector expressing nitroreductase and GMCSF (AdNRGM) given via trans-perineal, template-guided, intra-prostatic injection, followed by intravenous CB1954, in patients with locally relapsed  Prostate Cancer.

The following trial documents are all password protected. 

Change of Staff

If there is a change of staff working on the trial please print off and complete the relevant registration form below. Please also ensure that the Signature and Delegation Log is updated. Return both documents to the AdUP Trial Office.

Trial Documents

Links to the current protocol, Patient Information Sheet, Informed Consent Form are provided below. If there has been a recent amendment to the trial please ensure you have R&D approval before using these documents.

Other documents (e.g. Amendments, Case Report Form, Serious Adverse Event Form, Guidelines, GP Letter, Release of Medical Information Form etc) can be found by clicking on the other menu items below. If you cannot find what you are looking for please contact the AdUP Trial Office.

Version Control Lists

The version numbers and dates of all documents used for the trial are captured on a Version Control Log. Links to the Version Control Lists used in this trial are below in reverse date order.


Please contact the Trial Office for information on and the relevant amended documentation and approval letters for this trial. Please ensure that you have R&D approval (if applicable) before using the latest versions of these documents.

Case Report Form


Other Trial Documents


To date there are no publications for this trial.

News and Events

To date there are no current news and events to add.

Contact Details

Chief Investigator

Dr Prashant Patel, Senior Lecturer in Urology & Honorary Consultant Urological Surgeon, University of Birmingham

AdUP Trial Office

Trial Coordinator:  Ann Pope
Trial Monitor:   Shaneed Hajee
Trial Management Team Leader:  Joshua Savage

Cancer Research UK Clinical Trials Unit (CRCTU)
School of Cancer Sciences
University of Birmingham
B15 2TT


Telephone: +44 (0)121 414 5372
Fax: +44 (0)121 414 2230

Trial Entry

Telephone: +44 (0)121 414 6788 or +44 (0)121 414 7611
(9.00 am till 5.00 pm Monday to Friday)

Serious Adverse Event Reporting

Fax: +44 (0)121 414 3529 or +44 (0)121 414 3700


University of Birmingham