A multivalent porin mRNA vaccine against diseases caused by Salmonella

Summary 

Infections caused by Salmonella represent a major public health problem globally, even more so with the raise in antimicrobial resistance. In this project we take advantage of mRNA vaccine technology to test several vaccine candidates based on Salmonella porins. The vaccine protection will be evaluated in mice challenged with different Salmonella serovars.

We aim to obtain proof-of-concept evidence that a multivalent Salmonella mRNA vaccine could provide cross protection against endemic, typhoid and non typhoid strains that cause systemic and gastrointestinal manifestations.