Thrombosis and Haemostasis - University of Birmingham

Thrombosis and Haemostasis encompasses a range of disorders which are collectively the major killers of mankind and are usually triggered by injury to blood vessels and inappropriate activation of platelets and the coagulation system inside a blood vessel. Our theme is made up of multiple individual research groups and brings together clinical and non-clinical academics with multidisciplinary expertise in discovery and translational science.

We work very closely with the major NHS trusts across Birmingham including University Hospitals Birmingham, Sandwell and West Birmingham Hospitals, and Birmingham Women's and Children's Hospitals, which greatly enhances our translational capabilities.

Theme Leads

Professor Neil Morgan
Professor of Cardiovascular Genetics
Staff profile for Professor Neil Morgan, Professor of Cardiovascular Genetics, at the Department of Cardiovascular Sciences, College of Medicine and Health, University of Birmingham.
Dr Mark Thomas
Associate Professor of Cardiology and Honorary Consultant Cardiologist
Staff Profile of Dr Mark Thomas, Associate Professor of Cardiology and Honorary Consultant Cardiologist in the Department of Cardiovascular Sciences, University of Birmingham.

Department of Cardiovascular Sciences Research Theme: Thrombosis and Haemostasis

Introduction to the Thrombosis and Haemostasis research theme at the Department (formerly Institute) of Cardiovascular Sciences

Introduction to the Thrombosis and Haemostasis research theme at the Department of Cardiovascular Sciences

Transcript

Professor Neil Morgan: Hello, I'm Professor Neil Morgan. I jointly lead the theme for Thrombosis and Haemostasis within the Institute of Cardiovascular Sciences at the University of Birmingham with my colleague Dr Mark Thomas.

Dr Mark Thomas: Thrombosis causes heart attacks, strokes, and deep vein thrombosis. Our haemostasis research looks at all the different causes of excessive bleeding, and really we want to actually try and understand the causes of these diseases, so we can then go on to develop new treatments for these and, in the end, result in benefit for our patients.

Professor Neil Morgan: Our theme involves interdisciplinary research with both clinical and basic science colleagues in order to carry out the most cutting-edge research within the haemostasis and thrombosis field.

Dr Mark Thomas: One of the things that actually we’re really quite world leading in here is platelet biology, and we have access to a full range of different in vitro and in vivo techniques. We also have completely state-of-the-art equipment to look at the full range of different areas of science related to this. And when you combine that with our very close collaborations with the University Hospitals Birmingham, Sandwell and West Birmingham's Hospitals, and the [Birmingham] Women's and Children's Hospitals, we really do have a huge amount of translational capability.

Professor Mark Thomas: We're proud to be part of the Haemostasis and Thrombosis theme, where it allows us to carry out research with our colleagues, both in Birmingham and collaborators across the world.

About our theme

Our world leading researchers use basic science and translational approaches to address some of the key challenges in thrombosis and haemostasis. From identifying the causes of disease through to improving the treatments options for patients, we investigate platelet and megakaryocyte biology through the use of mouse models and cell biology. Our clinical studies focus on the genetics of patients with rare bleeding disorders and novel antithrombotic strategies for patients with thrombotic disorders.

Our Principal Investigators

Principal Investigators

Professor Dirk-Peter Herten
Molecular level signalling of inflammation and thrombo-inflammation

Professor Neil Morgan
Identifying novel genes for inherited platelet disorders and associated bleeding and the underlying mechanisms

Professor Steve Watson
Molecular mechanisms of platelet activation

Dr Alexander Brill
Mechanisms of venous thrombosis and interplay between thrombosis and inflammation

Dr Pip Nicholson
Platelet activation, Venous Thromboembolism (VTE), Translational Medicine, Mass participation research

Dr Natalie Poulter
Understanding platelet activation and receptor signalling using advanced microscopy

Dr Julie Rayes
Understanding mechanisms of thromboinflammation in sterile and infectious conditions. In particular, I am interested in danger-associated molecular patterns effect on platelet and how it regulates its interaction with immune and endothelial cells

Dr Mark Thomas
Antithrombotic pharmacology, precision medicine and machine learning

Dr Steve Thomas
Platelet and Megakaryocyte Cytoskeletons, Advanced Fluorescent Microscopy

Honorary Principal Investigators

Dr Gillian Lowe Inherited platelet disorders

Associate/Affiliate Principal Investigators

Professor Georgios Gkoutos
Health Data Science, Bioinformatics, Artificial Intelligence for Health, Multmodal multiomics integrative analytics, Translational comparative phenomics, Precision Medicine

Dr Paul Harrison
Platelets, Neutrophils, Extracellular Vesicles, Trauma and Burns

Dr Patricia Lalor (Trish)
Human liver inflammation and fibrosis, endothelial and platelet biology and impact of these on inflammation

Dr Michael Tomlinson
Tetraspanins and associated membrane proteins

Our research groups

Birmingham Platelet Group