DNA Replication, Stability and Repair

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Our research is defining the normal mechanisms of DNA replication and repair, with the aim of understanding how it is deregulated in cancer cells. We are investigating the impact of specific classes of gene mutations, such as ATM, BRCA1, and MYBL2 on genome integrity. We examine the impact that processes such as transcription and replication have on genome stability.

 

Theme Lead

jo morrisJo Morris

Professor of Molecular Genetics

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Research groups

Aga Gambus Regulation of DNA replication by SUMO and ubiquitin
Paloma Garcia Genome stability in stem cells
Martin Higgs Lysine methylation and DNA damage
Jo Morris Breast cancer mutations that suppress DNA repair
Eva Petermann Petermann DNA replication and repair
Marco Saponaro        Transcription-mediated genome instability
Stephen Smerdon Genome stability and DNA repair
Tatjana Stankovic Genetics and biology of B cell malignancies
Grant Stewart Role of DNA damage response genes in disease
Malcolm Taylor Role of ATM in DNA repair and cancer
Joanna Parish HPV gene expression and replication
Sally Roberts HPV biology and carcinogenesis
Andrew Turnell Adenovirus biology and cellular transformation
Bryan Turner Regulation of histone modifications