Our research is defining the normal mechanisms of DNA replication and repair, with the aim of understanding how it is deregulated in cancer cells. We are investigating the impact of specific classes of gene mutations, such as ATM, BRCA1, and MYBL2 on genome integrity. We examine the impact that processes such as transcription and replication have on genome stability.
We recently discovered new ways the BRCA1 gene functions which could help expand our understanding of the development of ovarian and breast cancers. Results showed BRCA1 changes shape in order to protect vulnerable DNA until the copying machinery can be restarted. In addition, in some patients with a personal or family history of breast and ovarian cancer, the protective role of BRCA1 in DNA-copying is disabled - while its break repair function is still active.