DNA Replication, Stability and Repair

 

Replication fork 1250 x 400 for ICGS DNA replication page

Our research is defining the normal mechanisms of DNA replication and repair, with the aim of understanding how it is deregulated in cancer cells. We are investigating the impact of specific classes of gene mutations, such as ATM, BRCA1, and MYBL2 on genome integrity. We examine the impact that processes such as transcription and replication have on genome stability. 

We recently discovered new ways the BRCA1 gene functions which could help expand our understanding of the development of ovarian and breast cancers. Results showed BRCA1 changes shape in order to protect vulnerable DNA until the copying machinery can be restarted. In addition, in some patients with a personal or family history of breast and ovarian cancer, the protective role of BRCA1 in DNA-copying is disabled - while its break repair function is still active.

 

Theme Lead

jo morrisJo Morris

Professor of Molecular Genetics

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Research groups

Aga Gambus Regulation of DNA replication by SUMO and ubiquitin
Paloma Garcia Genome stability in stem cells
Martin Higgs Lysine methylation and DNA damage
Jo Morris Breast cancer mutations that suppress DNA repair
Eva Petermann Petermann DNA replication and repair
Marco Saponaro        Transcription-mediated genome instability
Stephen Smerdon Genome stability and DNA repair
Tatjana Stankovic Genetics and biology of B cell malignancies
Grant Stewart Role of DNA damage response genes in disease
Malcolm Taylor Role of ATM in DNA repair and cancer
Joanna Parish HPV gene expression and replication
Andrew Turnell Adenovirus biology and cellular transformation
Bryan Turner Regulation of histone modifications