Genotyping and Phenotyping of Platelets


We are a research group based in Birmingham and Sheffield and are working together to research patients who have problems with bleeding and may have a problem with their platelets.

Platelets are small circulating particles in the blood that help to form a clot (blood sticking together) when we cut ourselves or experience an injury. We are trying to investigate whether some individuals who bleed more than usual have problems with their platelets and would eventually like to look at the changes in their genetic code (DNA) that cause these problems.

Our group have already discovered several new platelet problems in patients who we have recruited into our study. To enter our study you need to have been seen and assessed by a haematology doctor in one of the hospitals who we work with, which are shown on the map and listed below:

  1. Birmingham Women's NHS Foundation Trust
  2. NHS Birmingham South Central CCG
  3. Birmingham Children's Hospital NHS Foundation Trust
  4. Queen Elizabeth Medical Centre, university hospitals Birmingham
  5. University Hospitals of Leicester NHS Trust
  6. Central Manchester University Hospitals NHS Foundation Trust
  7. Newcastle Upon Tyne NHS Foundation Trust
  8. Queens Medical Centre, Nottingham University Hospitals NHS Trust 
  9. Cardiff and Vale University Health Board
  10. Royal Liverpool University Hospital
  11. Great Ormond Street Hospital, London
  12. University College London Hospitals NHS Foundation Trust 
  13. University Hospitals Coventry and Warwickshire NHS Trust
  14. Oxford University Hospitals NHS Trust, Radcliffe Hospital
  15. Guy's and St Thomas' NHS Foundation Trust, London
  16. Royal Devon and Exeter NHS Foundation Trust 
  17. Dudley Group NHSFoundation Trust
  18. Hull and East Yorkshire Hospitals NHS Trust, Castle Hill Hospital 
  19. Leeds Teaching Hospitals NHS Trust
  20. Bart’s Health NHS Trust, London
  21. Sheffield Children's NHS Foundation Trust 
  22. Royal Hospital for Sick Children, Edinburgh
  23. Imperial College Healthcare NHS Trust, London
  24. East Kent Hospitals University NHS Foundation Trust, Kent and Canterbury hospital
  25. United Lincolnshire Hospitals NHS Trust
  26. Our Lady’s Children’s Hospital, Crumlin, Dublin


In October 2012 GAPP was selected as “study of the month” for the National Institute of Health Research Specialty Groups newsletter. This is fantastic news and reflects the hard work that all the members of the GAPP team have put into the study.