Ladder A Treatment Information In 'For Trial Participants' Participating in the MEDAL TrialSummary MEDAL PISLadder A Treatment InformationLadder B Treatment InformationLadder C Treatment InformationLadder E Treatment InformationLadder F Treatment Information Download a PDF copy of the Ladder A Treatment Information Sheet Your Medications Step 1: Naproxen 500mg twice daily (with food) Step 2: Add Co-codamol 30/500 2 tablets four times daily Step 3: Add Amitriptyline 10mg at night Step 4: Stop Amitriptyline 10mg and start Amitriptyline 25mg at night The instructions for your medications are as follows: How to reduce your medications De-escalation from Step 1 De-escalation from Step 2 De-escalation from Step 3 De-escalation from Step 4