Ladder E Treatment Information In 'For Trial Participants' Participating in the MEDAL TrialSummary MEDAL PISLadder A Treatment InformationLadder B Treatment InformationLadder C Treatment InformationLadder E Treatment InformationLadder F Treatment Information Download a PDF copy of the Ladder E Treatment Information Sheet Your Medications Step 1: Co-codamol 30/500 2 tablets four times daily Step 2: Stop Co-codamol 30/500 and add Tramadol 100mg four times daily. Step 3: Add Amitriptyline 10mg at night. Step 4: Stop Amitriptyline 10mg and start Pregabalin 50mg three times daily. The instructions for your medications are as follows: How to reduce your medications De-escalation from Step 1 De-escalation from Step 2 De-escalation from Step 3 De-escalation from Step 4
