Ladder C Treatment Information In 'For Trial Participants' Participating in the MEDAL TrialSummary MEDAL PISLadder A Treatment InformationLadder B Treatment InformationLadder C Treatment InformationLadder E Treatment InformationLadder F Treatment Information Download a PDF copy of the Ladder C Treatment Information Sheet Your Medications Step 1: Naproxen 250mg twice daily (with food) Step 2: Stop Naproxen 250mg and add Naproxen 500mg twice daily (with food) Step 3: Add Amitriptyline 10mg at night. Step 4: Stop Amitriptyline 10mg add Amitriptyline 25mg at night. The instructions for your medications are as follows: How to reduce your medications De-escalation from Step 1 De-escalation from Step 2 De-escalation from Step 3 De-escalation from Step 4