Neurosurgery Pillar In 'ROSSINI-Platform' Rossini PlatformRecruitment & Participating SitesCardiacGroinLower Limb AmputationNeurosurgeryData & PrivacyContact Us ROSSINI-Platform aims to recruit up to 26,000 patients over a period of 5 years from NHS Trusts across the UK. Interventions 1) Bone flap wash and store in betadine vs. saline 2) Large volume wound irrigation vs. standard practice 3) Topical vancomycin into wound vs. none Key Inclusion Criteria Patients >12yrs undergoing craniotomy. Neurosurgery Team Members Lead: Ellie Edlemann Co-PI: Michael Jenkinson Pillar-Specific Documentation Neuro Protocol to be added when approved.