Mother-to-child transmission (MTCT) In 'About PregCOV-19LSR' About PregCOV-19LSRProtocolCOVID-19 in Pregnancy: webinar seriesMother-to-child transmissionPrevalencePresentationMother outcomesBaby outcomesRisk factorsDiagnosingTreatment Back to 'PregCOV-19LSR' What is the risk of mother-to-child SARS-Cov-2 transmission a) in utero, b) intrapartum, and c) postpartum? What is the presence and persistence of the virus in amniotic fluid, cord blood, placenta, neonatal throat swabs, vaginal fluids, faeces, serology (IgM, IgG) and breast milk? Transmission risks to baby Version 2: updated 28 May 2020 Of the 869 babies tested, 52 were suspected to have COVID-19. Eight babies had positive nasopharyngeal swab for the virus within 12 hours of birth. In very few cases, the virus has been detected by RT-PCR in amniotic fluid (n=1), placenta and placental membranes (n=6) , cord blood (n=1), vaginal fluid (n=1), neonatal plasma (n=1), and neonatal anal or faecal samples (n=4) There was no case of confirmed in utero, intrapartum or postpartum transmission Studies varied in the rigour with which the mother-to-child transmission was ascertained To-date, there is no confirmed mother-to-child transmission of Sars-COV-2 (v2.0 last search update on 12th May 2020; findings may change as new evidence emerges) Disclaimer: The findings have not yet been peer reviewed and the sources cited should be checked. Any views expressed are those of the authors and not necessarily those of their institutions and organisations. Previous versions Version 1: 4 May 2020 Structured research question (PICO) Mother-to-child transmission risk of COVID-19 infection Population Babies born to mothers with suspected/confirmed COVID-19 Exposure In-utero, intrapartum, postpartum Comparator - Outcomes Offspring COVID infection status (confirmed, probable, possible, unlikely, not infected)Viral levels in amniotic fluid, cord blood, vaginal fluids, breast milk, neonatal throat swabs, placenta; duration of viral shedding after COVID-19 symptom onset, after clinical resolution of signs/symptoms Study design Observational studies Findings Full details to be published shortly. Currently undergoing peer review.