Treatments for prevention and treatment of COVID-19 in pregnancy

What are the effects of therapeutic interventions to prevent maternal and offspring mortality and morbidity in pregnant and postnatal women with COVID-19?

Structured research question (PICO)

Interventions to prevent or treat COVID-19 and complications in pregnant/postpartum women
Population Pregnant/postpartum women with suspected/ confirmed COVID-19
Exposure Drugs, Personal Protection Equipment (PPE), care pathways
Comparator Usual care, placebo
Outcomes COVID-related main outcomes: all-cause mortality, COVID-specific mortality, pneumonia, respiratory failure, ARDS (Acute Respiratory Distress Syndrome), Time from illness onset to outcome (death, recovery); secondary outcomes: Need of respiratory support (invasive ventilation, non-invasive ventilation, oxygenation), admission to ICU (Intensive Care Unit), ICU length of stay, sepsis, cardiac failure, coagulopathy, acute cardiac injury, acute kidney injury, acute hepatic failure, cytokine storm syndrome, central nervous system manifestations, secondary infection, duration of viral shedding
Study design Randomised trials, Observational studies


Full details to be published shortly. Currently undergoing peer review.