Birmingham Platelet Group

It is a platelet spread on fibrinogen labelled for actin (left) and phosphorylated tyrosine (middle) and imaged by Structured Illumination Microscopy (right).

Overview 

The Birmingham Platelet Group adopts a multidisciplinary approach in the investigation of platelet and megakaryocyte biology, which ranges from cell biology, signal transduction and functional studies through to the use of mouse models and studies on patients. 

Left, DIC Image of megakaryocyte undergoing platelet formation. Right, Fluorescence imaging of podosome in a megakaryocyte

Current Projects

  • Cell surface receptors and their signalling pathways, focusing on stimulatory and inhibitory tyrosine kinase-linked receptors e.g. GPVI and CLEC-2
  • Structural studies on ligand binding
  • The genetics of platelet bleeding disorders
  • Megakaryocytopoiesis and platelet formation
  • Models of venous and arterial thrombosis
  • Animal models of cardiovascular diseases
  • Actin polymerisation
  • Super-resolution microscopy
  • Platelet function testing
  • Granule biogenesis and secretion
  • Role of platelets in inflammation and infection
  • Extracellular vesicles
  • Platelet procoagulant activity

Selected Publications

Paul Harrison

  1. Montague SJ, Delierneux C, Lecut C, Layios N, Dinsdale RJ, Lee CS, Poulter NS, Andrews RK, Hampson P, Wearn CM, Maes N, Bishop J, Bamford A, Gardiner C, Lee WM, Iqbal T, Moiemen N, Watson SP, Oury C, Harrison P and Gardiner EE. Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI. Blood Adv. 2018 Feb 13;2(3):240-251. doi: 10.1182/bloodadvances.2017011171
  2. Al Ghaithi R, Drake S, Watson SP, Morgan NV and Harrison P. Comparison of multiple electrode aggregometry with lumi-aggregometry for the diagnosis of patients with mild bleeding disorders. J Thromb Haemost. 2017 Oct;15(10):2045-2052. doi: 10.1111/jth.13784. Epub 2017 Sep 13

Neil Morgan

  1. Fletcher SJ, Johnson B, Lowe GC, Bem D, Drake S, Lordkipanidzé M, Sánchez Guiú I,Dawood B, Rivera J, Simpson MA, Daly ME, Motwani J, Collins PW, Watson SP and Morgan NV  SLFN14 mutations underlie thrombocytopenia with excessive bleeding and platelet secretion defects. J Clin Invest (2015), 125 (9), 3600-05.
  2. Damgaard RB, Walker JA, Marco-Casanova P, Morgan NV, Titheradge HL, Elliott PR, McHale D, Maher ER, McKenzie ANJ and Komander D. The deubiquitinase OTULIN is an essential negative regulator of inflammation and autoimmunity. Cell (2016) 166, 1215-30.

Natalie Poulter 

  1. Montague SJ Delierneux C, Lecut C, Layios N, Dinsdale RJ, Lee CS, Poulter NS, Andrews RK, Hampson P, Wearn CM, Maes N, Bishop J, Bamford A, Gardiner C, Lee WM, Iqbal T, Moiemen N, Watson SP, Oury C, Harrison P and Gardiner EE. Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI. Blood Adv. 2018 Feb 13;2(3):240-251.
  2. Poulter N.S, Pollitt A.Y, Owen D.M, Gardiner E.E, Andrews R.K, Shimizu H, Ishikawa D, Bihan D, Farndale R.W, Moroi M, Watson S.P and Jung S.M. Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets (2017). Journal of Thrombosis and Haemostasis, 15(3):549-564. 

Steve Watson

  1. Rayes J, Lax S, Wichaiyo S, Watson S, Di Y, Lombard S, Grygielska B, Smith S, Skordilis K and Watson SP. The podoplanin-CLEC-2 axis inhibits inflammation in sepsis.  (2017) Nature Commun. 8: 2239
  2. Mangin PH, Onselaer MB, Receveur N, Le Lay N, Hardy AT, Wilson C, Sanchez X, Loyau S, Depuis A, Babar AK, Miller JLC,  Philippou H, Hughes CE, Herr AB, Ariëns RAS, Mezzano D, Jandrot-Perrus M, Gachet C and Watson SP. Immobilized fibrinogen activates human platelets through GPVI. (2018) Haematologica in press

For full publications lists see:

Staff

Bham Platelet Group April 2019

Principal Investigators

Alexander Brill
Paul Harrison
Neil Morgan
Natalie Poulter
Yi Sun
Mark Thomas
Steve Thomas
Steve Watson

Postdoctoral researchers

Ruben Barroso
Amanda Dalby
Abdullah Khan

Julie Rayes
Alexandre Slater
Malou Zuidscherwoude

PhD/MD Students

Pip Nicolson
Ibrahim Almazni
Fawaz Alenazy
Joanne Clark
Tom O'Sullivan
Chiara Pallini
Gina Perella
Chris Smith

Research Technicians

Mrs Ying Di
Mrs Lourdes Garcia-Quintanilla
Dr Beata Grygielska 

Research Co-Ordinator

 Mrs Gayle Halford

Close ties with other Principal Investigators on platelet related projects

Professor Roy Bicknell - Professor of Functional Genomics
Dr Andrew Blann - Non-clinical Senior Lecturer
Dr Neena Kalia - Senior Lecturer in Cardiovascular Sciences
Professor Gregory Y H Lip - Consultant Cardiologist & Prof of Cardiovascular Medicine
Dr Melanie Madhani - Senior Lecturer in Cardiovascular Medicine
Professor Gerard Nash - Professor of Cardiovascular Rheology
Professor Ed Rainger - Professor of Chronic Inflammation
Dr Michael Tomlinson - Senior Lecturer in the School of Biosciences
Dr Gillian Lowe - Consultant in Haemostasis and Thrombosis / Hon Senior Lecturer
Dr Mike Williams - Consultant Paediatric Haematologist/Honorary Lecturer

Videos

Understanding the Role of Platelets in Sepsis

New Anti Platelet Drugs for Cardiovascular Disease and Thrombosis

A Collaborative Approach to Platelet Research

A Collaborative Approach to Platelet Research

Platelets in thrombosis and bleeding

Platelets in thrombosis and bleeding

Platelets in Inflammatory Disease

Platelets in Inflammatory Disease

New Anti Platelet Drugs for Cardiovascular Disease and Thrombosis

New Anti Platelet Drugs for Cardiovascular Disease and Thrombosis

 

 

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