Birmingham Platelet Group In 'Birmingham Platelet Group' Birmingham Platelet Research GroupGenotyping and Phenotyping of Platelets Back to 'Our research' Overview The Birmingham Platelet Group adopts a multidisciplinary approach in the investigation of platelet and megakaryocyte biology, which ranges from cell biology, signal transduction and functional studies through to the use of mouse models and studies on patients. Current Projects Cell surface receptors and their signalling pathways, focusing on stimulatory and inhibitory tyrosine kinase-linked receptors e.g. GPVI and CLEC-2 Structural studies on ligand binding The genetics of platelet bleeding disorders Megakaryocytopoiesis and platelet formation Models of venous and arterial thrombosis Animal models of cardiovascular diseases Actin polymerisation Super-resolution microscopy Platelet function testing Granule biogenesis and secretion Role of platelets in inflammation and infection Extracellular vesicles Platelet procoagulant activity Selected Publications Paul Harrison Montague SJ, Delierneux C, Lecut C, Layios N, Dinsdale RJ, Lee CS, Poulter NS, Andrews RK, Hampson P, Wearn CM, Maes N, Bishop J, Bamford A, Gardiner C, Lee WM, Iqbal T, Moiemen N, Watson SP, Oury C, Harrison P and Gardiner EE. Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI. Blood Adv. 2018 Feb 13;2(3):240-251. doi: 10.1182/bloodadvances.2017011171 Al Ghaithi R, Drake S, Watson SP, Morgan NV and Harrison P. Comparison of multiple electrode aggregometry with lumi-aggregometry for the diagnosis of patients with mild bleeding disorders. J Thromb Haemost. 2017 Oct;15(10):2045-2052. doi: 10.1111/jth.13784. Epub 2017 Sep 13 Neil Morgan Fletcher SJ, Johnson B, Lowe GC, Bem D, Drake S, Lordkipanidzé M, Sánchez Guiú I,Dawood B, Rivera J, Simpson MA, Daly ME, Motwani J, Collins PW, Watson SP and Morgan NV SLFN14 mutations underlie thrombocytopenia with excessive bleeding and platelet secretion defects. J Clin Invest (2015), 125 (9), 3600-05. Damgaard RB, Walker JA, Marco-Casanova P, Morgan NV, Titheradge HL, Elliott PR, McHale D, Maher ER, McKenzie ANJ and Komander D. The deubiquitinase OTULIN is an essential negative regulator of inflammation and autoimmunity. Cell (2016) 166, 1215-30. Natalie Poulter Montague SJ Delierneux C, Lecut C, Layios N, Dinsdale RJ, Lee CS, Poulter NS, Andrews RK, Hampson P, Wearn CM, Maes N, Bishop J, Bamford A, Gardiner C, Lee WM, Iqbal T, Moiemen N, Watson SP, Oury C, Harrison P and Gardiner EE. Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI. Blood Adv. 2018 Feb 13;2(3):240-251. Poulter N.S, Pollitt A.Y, Owen D.M, Gardiner E.E, Andrews R.K, Shimizu H, Ishikawa D, Bihan D, Farndale R.W, Moroi M, Watson S.P and Jung S.M. Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets (2017). Journal of Thrombosis and Haemostasis, 15(3):549-564. Steve Watson Rayes J, Lax S, Wichaiyo S, Watson S, Di Y, Lombard S, Grygielska B, Smith S, Skordilis K and Watson SP. The podoplanin-CLEC-2 axis inhibits inflammation in sepsis. (2017) Nature Commun. 8: 2239 Mangin PH, Onselaer MB, Receveur N, Le Lay N, Hardy AT, Wilson C, Sanchez X, Loyau S, Depuis A, Babar AK, Miller JLC, Philippou H, Hughes CE, Herr AB, Ariëns RAS, Mezzano D, Jandrot-Perrus M, Gachet C and Watson SP. Immobilized fibrinogen activates human platelets through GPVI. (2018) Haematologica in press For full publications lists see: Alexander Brill - publications Paul Harrison - publications Neil Morgan - publications Natalie Poulter - publications Steve Thomas - publications Steve Watson - publications Staff Principal Investigators Alexander BrillPaul HarrisonNeil MorganNatalie PoulterYi SunMark ThomasSteve ThomasSteve Watson Postdoctoral researchers Ruben BarrosoAmanda DalbyAbdullah KhanJulie RayesAlexandre SlaterMalou Zuidscherwoude PhD/MD Students Pip NicolsonIbrahim AlmazniFawaz AlenazyJoanne ClarkTom O'SullivanChiara PalliniGina PerellaChris Smith Research Technicians Mrs Ying DiMrs Lourdes Garcia-QuintanillaDr Beata Grygielska Research Co-Ordinator Mrs Gayle Halford Close ties with other Principal Investigators on platelet related projects Professor Roy Bicknell - Professor of Functional Genomics Dr Andrew Blann - Non-clinical Senior Lecturer Dr Neena Kalia - Senior Lecturer in Cardiovascular Sciences Professor Gregory Y H Lip - Consultant Cardiologist & Prof of Cardiovascular Medicine Dr Melanie Madhani - Senior Lecturer in Cardiovascular Medicine Professor Gerard Nash - Professor of Cardiovascular Rheology Professor Ed Rainger - Professor of Chronic Inflammation Dr Michael Tomlinson - Senior Lecturer in the School of Biosciences Dr Gillian Lowe - Consultant in Haemostasis and Thrombosis / Hon Senior Lecturer Dr Mike Williams - Consultant Paediatric Haematologist/Honorary Lecturer Funding Bodies British Heart Foundation Engineering and Physical Sciences Research Council (EPSRC) Healing Foundation Medical Research Council (MRC) National Institute for Health Research (NIHR) Wellcome Trust Videos Understanding the Role of Platelets in Sepsis New Anti Platelet Drugs for Cardiovascular Disease and Thrombosis A Collaborative Approach to Platelet Research A Collaborative Approach to Platelet Research Platelets in thrombosis and bleeding Platelets in thrombosis and bleeding Platelets in Inflammatory Disease Platelets in Inflammatory Disease New Anti Platelet Drugs for Cardiovascular Disease and Thrombosis New Anti Platelet Drugs for Cardiovascular Disease and Thrombosis @bhamplateletgrp Browser does not support script. 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