Principal Investigators

IMSR_090218_NRP-58_Group shot PI

Dr Ildem Akerman

Dr Ildem Akerman

Member of the 2017/18 Birmingham Fellows
Birmingham Fellow

Dr. Akerman is interested in answering fundamental questions about gene regulation in diseased and healthy pancreatic beta cells through integrated use of molecular, genomic, computational and systems biology. In particular, her aim is to understand how various types of noncoding DNA elements interact to establish gene expression in the pancreatic beta cell.

Member of the 2017/18 Birmingham ...

Professor Wiebke Arlt

Professor Wiebke Arlt

William Withering Chair of Medicine
Director of the Institute of Metabolism and Systems Research

Wiebke’s research investigates the role of steroids in health and disease, both in common disease with increased metabolic risk (polycystic ovary syndrome, fatty liver disease, adrenal incidentaloma) and rare adrenal and gonadal disorders.

Dr Kristien Boelaert

Dr Kristien Boelaert

Reader in Endocrinology

Kristien’s translational research includes management of thyroid dysfunction and nodules as well as endocrine disorders in pregnancy. Her laboratory research programme aims to improve the treatment of goitre and thyroid cancer. 

Dr Leigh Breen

Dr Leigh Breen

Senior Lecturer in Exercise Physiology and Metabolism

Dr Breen's expertise centres on understanding the regulation of muscle metabolism in health and disease. Dr Breen has a particular interest in how exercise and nutritional interventions can modify metabolic processes to enhance musculoskeletal remodelling, leading to improved health and performance outcomes.

Professor Davide Calebiro

Professor Davide Calebiro

Professor of Molecular Endocrinology
Wellcome Senior Research Fellow

Davide's group investigates the basic mechanisms of receptor signalling and their alterations in endocrine diseases. They focus on G protein-coupled receptors (GPCRs), which mediate the effects of several hormones and are major drug targets. To investigate receptor nanodomains they develop and use advanced optical methods such as fluorescence resonance energy transfer (FRET) and single-molecule ...

Professor Arri Coomarasamy

Professor Arri Coomarasamy

Professor of Gynaecology
Director of Tommy's National Centre for Miscarriage Research

Arri Coomarasamy is the Director of Tommy’s National Centre for Miscarriage Care and Research. His research interests are in fertility, early pregnancy and global women’s health.

Professor Helen J. Cooper

Professor Helen J. Cooper

Professor of Mass Spectrometry
Deputy Head of School
EPSRC Established Career Fellow

Helen is Professor of Mass Spectrometry and EPSRC Established Career Fellow. Her research focuses on the development and application of advanced mass spectrometry for the analysis of biomolecules, particularly peptides and proteins. Current areas of research include liquid extraction surface analysis of biological substrates such as dried blood spots, thin tissue sections and bacterial colonies; ...

Dr Gabriela Da Silva Xavier

Dr Gabriela Da Silva Xavier

Senior Lecturer in Cellular Metabolism

Gaby is Senior Lecturer in Cellular Metabolism and a Senior Fellow of the Higher Education Academy.  She has an interest in energy homeostasis, particularly in fuel sensing mechanisms that may play a role in diabetes and obesity.

Dr Vivek Dhir

Dr Vivek Dhir

Lecturer in Molecular Endocrinology
MPharm Admissions Tutor - Endocrinology, Diabetes and Metabolism

Vivek Dhir is a Lecturer in Molecular Endocrinology and has published a number of high impact research papers in scientific journals as well as reviews in the fields of endocrinology, metabolism and genetics. He has received major grants from the Welcome trust and The MRC.

Vivek is keen to talk about his science and gives frequent seminars to various groups at the local, national and ...

Dr Sarah Dimeloe

Dr Sarah Dimeloe

Birmingham Fellow

Sarah Dimeloe is a Birmingham Fellow working across the Institutes of Immunology and Immunotherapy (III), and Metabolism and Systems Research (IMSR).

Research in Sarah’s lab is focused on the metabolism of immune cells and how this underpins their role in health and disease.

Dr Dimeloe is a member of the 2017/18 Birmingham Fellows

Professor Warwick Dunn

Professor Warwick Dunn

Professor of Analytical and Clinical Metabolomics
Director of the Birmingham Metabolomics Training Centre
Director of Mass Spectrometry, Phenome Centre Birmingham

Warwick (Rick) is a Senior Lecturer in Metabolomics, Director of Mass Spectrometry in the Phenome Centre-Birmingham, Director of the Birmingham Metabolomics Training Centre, and theme leader in the MRC Arthritis Research UK Centre for Musculoskeletal Ageing. His research focuses on the development of new analytical chemistry and computational tools for studying metabolism at the holistic and ...

Professor Andrew Ewer

Professor Andrew Ewer

Professor in Neonatal Medicine

Andy Ewer's research focuses on identification of serious illness in newborn babies including cardiac defects, gastrointestinal disorders and sudden infant death. His work has lead to a worldwide uptake in screening for congenital heart disease.

Dr Paul Alexander Foster

Dr Paul Alexander Foster

Lecturer in Molecular Endocrinology

Paul leads the Steroid Metabolism in Cancer Research group at the University of Birmingham. He is an established research figure in the endocrinology and cancer fields. With over a decade of experience in both academic and industrial environments, he has extensive research knowledge on a wide-range of areas. He is an author on over 40 scientific peer-reviewed papers, covering endocrinology, ...

Professor Neil Gittoes

Professor Neil Gittoes

Honorary Professor of Endocrinology

Professor Neil Gittoes is Honorary Professor of Endocrinology and Head of the Centre for Endocrinology, Diabetes and Metabolism. He is an expert in metabolic bone diseases and mineral disorders and has a number of national leadership roles in those domains.

His clinical research interests focus on osteoporosis and rare causes of fracture susceptibility. He has co-authored national guidelines on ...

Dr Caroline Gorvin

Dr Caroline Gorvin

IMSR Career Development Fellow

Caroline’s research is focussed on the trafficking and signalling of membrane proteins, and how impairments in their signalling pathways contribute to endocrine disorders. In recent years this has concentrated on the role of the class C G-protein coupled receptor (GPCRs), Calcium-Sensing Receptor (CaSR), and components of its signalling pathway in calcium homeostasis. She is currently ...

Professor Janesh K. Gupta

Professor Janesh K. Gupta

Professor of Obstetrics and Gynaecology

Janesh Gupta’s research focuses on benign gynaecological disorders in the areas of menorrhagia / chronic pelvic pain / endometriosis and endometrial hyperplasia, methods for safe abortion and in new methods for induction of labour.

Dr Rowan Hardy

Dr Rowan Hardy

ARUK Career Development Fellow

Rowan’s research examines the mechanisms of endogenous and therapeutic glucocorticoid action in chronic inflammatory disease, with the aim of identifying novel therapeutic approaches in their management

Professor Martin Hewison

Professor Martin Hewison

Professor of Molecular Endocrinology
Deputy Director of the Institute of Metabolism and Systems Research

Martin’s group investigates the role vitamin D  plays in human health beyond its effects on bone. They focus on vitamin D and immune function, and how this influences infectious diseases, pregnancy and autoimmune disease.

Dr Tarekegn G Hiwot

Dr Tarekegn G Hiwot

Honorary Reader in Inherited Metabolic Disorders

Tarek’s research targets Alstrom Syndrome, a model of monogenic metabolic syndrome that can help us to understand severe insulin resistance and its complications.

Professor David J. Hodson

Professor David J. Hodson

Professor of Cellular Metabolism, Professorial Research Fellow

Research in Dave’s lab uses a combination of imaging, chemical biology and genetics to understand how subtle differences in the beta cell barcode may predispose to diabetes in rodents and man.

Dr Wolfgang Högler

Dr Wolfgang Högler

Reader in Paediatric Endocrinology

Wolfgang investigates the impact of disorders of growth hormone/IGF-1 and calcium/phosphate metabolism on growth and bone health in children. He aims to find novel diagnostic and therapeutic options in rare diseases affecting bone and growth.

Dr Niki Karavitaki

Dr Niki Karavitaki

Senior Clinical Lecturer in Endocrinology

Niki Karavitaki is a Senior Clinical Lecturer in Endocrinology and Honorary Consultant Endocrinologist at the Queen Elizabeth Hospital Birmingham where she co-leads the Pituitary Service and Pituitary MDT.

Her research and clinical interests focus on hypothalamo-pituitary disease (particularly sellar and parasellar tumours and hypopituitarism) covering pathogenesis, management and long-term ...

Professor Mark David Kilby

Professor Mark David Kilby

Dame Hilda Lloyd Professor of Fetal Medicine

Mark Kilby’s research focusses on materno-fetal health, with areas of interest including steroids and the feto-placental unit, new technologies in prenatal diagnosis, fetal in utero therapy, monochorionic twins, and maternal immunotolerance and fetal immunity.

Dr Jackson C. Kirkman-Brown MBE

Dr Jackson C. Kirkman-Brown MBE

Reader in Human Reproductive Biology

Jackson’s research is about andrology and its application in the diagnosis and treatment of infertility, with direct impact on care and quality of life of the patients involved and the birth of the next generation. 

Dr Yu-Chiang Lai

Dr Yu-Chiang Lai

Birmingham Fellow in Molecular Physiology

Yu-Chiang is a Birmingham Fellow in the School of Sport, Exercise and Rehabilitation Sciences and the MRC-ARUK Centre for Musculoskeletal Ageing Research.   

Yu-Chiang’s lab is focused on the signalling networks that regulate skeletal muscle metabolic functions. We seek to understand the molecular mechanisms that lead to muscle atrophy and how exercise is able to improve skeletal ...

Professor Gareth G Lavery

Professor Gareth G Lavery

Professor of Molecular Metabolism
Wellcome Trust Senior Research Fellow

The Molecular Metabolism Research Group led by Gareth Lavery investigates mechanisms by which nutrients and hormones manage the control of skeletal muscle metabolic energy pathways in normal and adaptive physiology.

Dr Christian Ludwig

Dr Christian Ludwig

Lecturer in Metabolic Biophysics

Christian’s research is focused on developing novel experimental and analytical approaches to map metabolic pathway activities without assuming a particular metabolism model.

Dr Konstantinos Manolopoulos

Dr Konstantinos Manolopoulos

Clinician Scientist in Endocrinology and Human Metabolism

Konstantinos is exploring the hormonal determinants of adipose tissue function in vivo, and the factors leading to adipocyte dysfunction in obesity.

Dr Kendle Michelle Maslowski

Dr Kendle Michelle Maslowski

Birmingham Fellow

Kendle is a Birmingham Fellow working across the Institutes of Immunology and Immunotherapy (III), and Metabolism and Systems Research (IMSR).

Research in Kendle’s lab is focussed on understanding innate immune pathways in intestinal epithelial cells and their roles in fighting infection and cancer development.

Professor Chris McCabe

Professor Chris McCabe

Professor of Molecular Endocrinology

Chris McCabe’s group focuses on the aetiology of endocrine tumourigenesis in models of thyroid and breast cancer. Our particular interest lies in improving radioiodine treatment. 

Dr R. Katie Morris

Dr R. Katie Morris

Senior Clinical Lecturer in Maternal Fetal Medicine

Katie’s research aims to improve the care for women with multiple pregnancies, fetal anomalies, growth restriction, reducing infection in maternity and prevention of preterm birth, employing prognostic and diagnostic research, modelling, systematic reviews and trials.

Dr Jonathan W. Mueller

Dr Jonathan W. Mueller

Lecturer in Endocrine Biochemistry

Jon is interested in the many aspects of steroid regulation by sulfation/desulfation processes with implications in pregnancy as well as androgen excess disorders and steroid-dependent cancers.

Dr Michael W. O'Reilly

Dr Michael W. O'Reilly

Clinician Scientist in Endocrinology and Human Metabolism

Mick’s research aims to understand the sexually dimorphic effects of androgens in men and women, and the mechanisms underpinning the metabolic disturbances, morbidity and mortality associated with androgen excess in women and hypogonadism in men.

Dr Thomas Papathomas

Dr Thomas Papathomas

Clinician Scientist in Molecular Pathology

Thomas’ research focuses on molecular pathology and aims to define in-situ metabolomic signatures for diagnostic classification and prognostic evaluation in diverse human tumour types.

Dr Cristina L. Ronchi

Dr Cristina L. Ronchi

Clinician Scientist in Endocrine Oncology

Cristina Ronchi is an Endocrinologist and clinician scientist with long-standing expertise in endocrine tumors. Her research field mostly focuses on genetic studies and investigations of molecular markers involved in the pathogenesis and prognosis of adrenocortical neoplasia.  She is particularly active in research dissemination and collaborates with several world-leading groups around ...

Dr Alexandra J. Sinclair

Dr Alexandra J. Sinclair

NIHR Clinician Scientist Fellow

Alex’ group focuses on metabolic neurology: idiopathic intracranial hypertension, headache and cerebrospinal fluid (CSF) disorders. Our translational approach investigates disease pathogenesis and novel therapeutic targets which we then evaluate in our clinical studies.

Professor David Smith

Professor David Smith

Professor of Applied Mathematics

Dave Smith is Professor of Applied Mathematics and School Director of Research.

He is author or co-author of approximately 50 research papers in scientific journals, including in the Internationally-leading publications Annual Review of Fluid Mechanics, Proceedings of the National Academy of Sciences, Journal of Fluid Mechanics, and Proceedings of the Royal Society of London A. Research software ...

Dr Vicki E. Smith

Dr Vicki E. Smith

Lecturer in Molecular Endocrinology

Vicki is interested in thyroid biology and the molecular pathogenesis of thyroid disease. Her research focuses on improving existing treatments and identifying novel therapies in thyroid cancer.

Dr Thomas P. J. Solomon

Dr Thomas P. J. Solomon

Senior Lecturer
European Commission Marie Curie Research Fellow

Our group’s work focusses on understanding the pathophysiological development of hyperglycaemia in type 2 diabetes and the role physical activity in its prevention and treatment.

Dr Abd A Tahrani

Dr Abd A Tahrani

NIHR Clinician Scientist

Abd Tahrani is a National Institute for Health Research (NIHR) Clinician Scientist at the University of Birmingham (UoB), and a Honorary Consultant Endocrinologist and the lead for weight management research and diabetic neuropathy services at Heart of England NHS Foundation Trust, Birmingham, UK.

He leads a multi-disciplinary research group that include scientists, clinicians and allied ...

Dr Daniel A. Tennant

Dr Daniel A. Tennant

Reader in Metabolic Biochemistry

Dan’s group investigates how cells respond to changes in oxygen tension in health and disease. In particular, we are interested in the metabolic perturbations induced by hypoxia, and how this drives disease processes.

Professor Peter Tino

Professor Peter Tino

Chair in Complex and Adaptive Systems

Peter Tiňo is Professor of Complex and Adaptive Systems at the School of Computer Science at the University of Birmingham. He is the author of over 160 research articles in the areas of dynamical systems, machine learning, natural computation and fractal geometry. Peter has been awarded three outstanding Journal Paper of the Year awards and the Head of School's Excellence in Teaching Award.

Professor Mark Viant

Professor Mark Viant

Professor of Metabolomics
Director of Phenome Centre Birmingham and NERC Biomolecular Analysis Facility - Metabolomics Node
Past President of the International Metabolomics Society

60 second video iconProfessor Mark Viant’s expertise lies in the field of metabolomics. His research spans from method development in analytical chemistry and bioinformatics through to the application of metabolomics to environmental toxicology.