Principal Investigators

Institute of Metabolism and System Research Principal Investigators

Dr Ildem Akerman

Dr Ildem Akerman

Birmingham Fellow, Diabetes UK RD Lawrence Fellow
Birmingham Fellow

Dr. Akerman is interested in answering fundamental questions about gene regulation in diseased and healthy pancreatic beta cells through integrated use of molecular, genomic, computational and systems biology. In particular, her aim is to understand how various types of noncoding DNA elements interact to establish gene expression in the pancreatic beta cell.

Member of the 2017/18 Birmingham ...

Dr John Allotey

Dr John Allotey

Lecturer in Epidemiology and Women’s Health

John Allotey is a lecturer in epidemiology and women’s health at the WHO Collaborating Centre for Global Women's Health within the Institute of Metabolism and Systems Research. He has almost a decade of experience in academic clinical research, primarily in the field of maternal health. His research interests lie in the development, evaluation and implementation of prognostic models, and ...

Professor Wiebke Arlt

Professor Wiebke Arlt

William Withering Chair of Medicine
Director of the Institute of Metabolism and Systems Research

Wiebke’s research investigates the role of steroids in health and disease, both in common disease with increased metabolic risk (polycystic ovary syndrome, fatty liver disease, adrenal incidentaloma) and rare adrenal and gonadal disorders.

Professor Davide Calebiro

Professor Davide Calebiro

Professor of Molecular Endocrinology
Wellcome Trust Senior Research Fellow

Davide Calebiro is a Professor of Molecular Endocrinology and Wellcome Trust Senior Research Fellow at the Institute of Metabolism and Systems Research (IMSR) and the Centre of Membrane Proteins and Receptors (COMPARE) of the University of Birmingham.

He leads a multidisciplinary research team comprising biologists, chemists, physicists, engineers and computer scientists focusing on the basic ...

Professor Arri Coomarasamy

Professor Arri Coomarasamy

Professor of Gynaecology and Reproductive Medicine
Director of the Tommy's National Centre for Miscarriage Research
Joint Director of the WHO Collaborating Centre for Global Women’s Health

Professor Coomarasamy is the Director of Tommy’s National Centre for Miscarriage Care and Research. His research interests are in fertility, early pregnancy and global women’s health.

Dr Gabriela Da Silva Xavier

Dr Gabriela Da Silva Xavier

Senior Lecturer in Cellular Metabolism
Medical and Dental Sciences Post-Graduate Research Quality Assurance Lead
IMSR Lead for Equality, Diversity & Inclusion and IMSR Deputy Lead for Postgraduate Research

Gaby is Senior Lecturer in Cellular Metabolism and a Senior Fellow of the Higher Education Academy.  She has an interest in energy homeostasis, particularly in fuel sensing mechanisms that may play a role in diabetes and obesity.

Dr Rima K. Dhillon-Smith

Dr Rima K. Dhillon-Smith

Clinical Lecturer in Early Pregnancy and Reproductive Medicine

Dr Rima Dhillon-Smith is a clinical lecturer based at the  Birmingham Women’s and Children’s Hospital NHS Foundation Trust. She combines her academic work with clinical duties as a registrar in Obstetrics and Gynaecology.  Rima’s main research interests lie in reproductive endocrinology, subfertility, paediatric gynaecology and early pregnancy.  She is a key ...

Dr Sarah Dimeloe

Dr Sarah Dimeloe

Birmingham Fellow
European Commission Marie Sklodowska Curie Fellow
Leukemia UK John Goldman Fellow

Sarah Dimeloe is a Birmingham Fellow working across the Institutes of Immunology and Immunotherapy (III), and Metabolism and Systems Research (IMSR).

Research in Sarah’s lab is focused on the metabolism of immune cells and how this underpins their role in health and disease.

Dr Dimeloe is a member of the 2017/18 Birmingham Fellows

Professor Andrew Ewer

Professor Andrew Ewer

Professor in Neonatal Medicine

Andy Ewer's research focuses on identification of serious illness in newborn babies, including cardiac defects, gastrointestinal disorders and sudden infant death. His work has lead to a worldwide uptake in screening for congenital heart disease.

Dr Paul Alexander Foster

Dr Paul Alexander Foster

Senior Lecturer in Cancer Endocrinology
IMSR Lead for Postgraduate Research
IMSR Senior Tutor

Paul leads the Steroid Metabolism in Cancer Research group at the University of Birmingham. He is an established research figure in the endocrinology and cancer fields. With over a decade of experience in both academic and industrial environments, he has extensive research knowledge on a wide-range of areas. He is an author on over 40 scientific peer-reviewed papers, covering endocrinology, ...

Dr Ioannis D Gallos

Dr Ioannis D Gallos

Senior Lecturer in Global Women's Health
Joint Director of WHO Collaborating Centre for Global Women's Health

Ioannis’ research work focusses on health issues affecting women and families living in resource-constrained settings, particularly targeting on ways to stop mothers dying from excessive bleeding during childbirth.

Every six minutes, a mother dies from losing too much blood while giving birth. The tragedy is that this is almost always preventable.

Oxytocin is the standard medicine for the ...

Professor Neil Gittoes

Professor Neil Gittoes

Consultant and Honorary Professor of Endocrinology

Professor Neil Gittoes has led the development of The Centre for Endocrinology Diabetes and Metabolism(CEDAM) through close partnership working between the University of Birmingham and a clinical services consortium across major teaching Trusts in Birmingham. Through closer integration and understanding, CEDAM has facilitated translational research in endocrinology, diabetes and metabolism and ...

Dr Caroline Gorvin

Dr Caroline Gorvin

IMSR Career Development Fellow

Caroline’s research is focussed on the trafficking and signalling of membrane proteins, and how their impairments contribute to endocrine and metabolic disease. She is currently establishing her research group investigating metabolic GPCRs and how they integrate hormonal signals to regulate appetite. 

Professor Janesh K. Gupta

Professor Janesh K. Gupta

Professor of Obstetrics and Gynaecology

Janesh Gupta is Professor of Obstetrics and Gynaecology working as an Honorary Consultant at Birmingham Women’s and Children’s Hospital.

Janesh has published over 175 research papers in scientific journals, book chapters, reviews and books and over 100 lectures and presentations to learned societies in the fields of fetal medicine, benign gynaecology (including abnormal uterine ...

Dr Rowan Hardy

Dr Rowan Hardy

Versus Arthritis Career Development Fellow

I am a Versus Arthritis Fellow with extensive experience in steroid metabolism and in vivo models of chronic inflammation. Patients with chronic inflammatory diseases develop systemic complications such as muscle wasting and bone loss, which contribute to disability and reduced life expectancy. My research group is examining the roles of myeloid and mesenchymal steroid metabolism and signalling ...

Professor Martin Hewison

Professor Martin Hewison

Professor of Molecular Endocrinology
IMSR Director of Education

Martin’s group investigates the role vitamin D  plays in human health beyond its effects on bone. They focus on vitamin D and immune function, and how this influences infectious diseases, pregnancy and autoimmune disease.

Professor David J. Hodson

Professor David J. Hodson

Professor of Cellular Metabolism, Professorial Research Fellow
IMSR Lead for Global Engagement

Research in Dave’s lab uses a combination of imaging, chemical biology and genetics to understand how subtle differences in the beta cell barcode may predispose to diabetes in rodents and man.

Dr Jan Idkowiak

Dr Jan Idkowiak

Academic Clinical Lecturer in Paediatric Endocrinology and Diabetes

Jan is an NIHR Clinical Lecturer in Paediatric Endocrinology, based at the IMSR and at the Department of Endocrinology at the Birmingham Children’s Hospital. His research focuses androgen metabolism. He is interested in inborn errors of steroid metabolism, in particular conditions affecting androgen generation. He combines clinical phenotyping and genetic analysis with in vitrofunctional ...

Dr Niki Karavitaki

Dr Niki Karavitaki

Senior Clinical Lecturer in Endocrinology
IMSR Lead for Continuous Professional Development

Niki Karavitaki is a Senior Clinical Lecturer in Endocrinology and Honorary Consultant Endocrinologist at the Queen Elizabeth Hospital Birmingham where she co-leads the Pituitary Service and Pituitary MDT.

Her research and clinical interests focus on hypothalamo-pituitary disease (particularly sellar and parasellar tumours and hypopituitarism) covering pathogenesis, management and long-term ...

Professor Mark David Kilby

Professor Mark David Kilby

Dame Hilda Lloyd Professor of Fetal Medicine

Mark Kilby’s research focusses on materno-fetal health, with areas of interest including steroids and the feto-placental unit, new technologies in prenatal diagnosis, fetal in utero therapy, monochorionic twins, and maternal immunotolerance and fetal immunity.

Dr Jackson C. Kirkman-Brown MBE

Dr Jackson C. Kirkman-Brown MBE

Reader in Human Reproductive Biology

Jackson’s research is about andrology and its application in the diagnosis and treatment of infertility, with direct impact on care and quality of life of the patients involved and the birth of the next generation. 

Professor Gareth G Lavery

Professor Gareth G Lavery

Professor of Molecular Metabolism
Wellcome Trust Senior Research Fellow
Theme Lead Metabolism & IMSR Deputy Director

The Molecular Metabolism Research Group led by Gareth Lavery investigates mechanisms by which nutrients and hormones manage the control of skeletal muscle metabolic energy pathways in normal and adaptive physiology.

Dr Christian Ludwig

Dr Christian Ludwig

Senior Lecturer in Metabolic Biophysics
IMSR Lead for Academic Integrity

Christian’s research is focused on developing novel experimental and analytical approaches to map metabolic pathway activities without assuming a particular metabolism model.

Dr Kendle Michelle Maslowski

Dr Kendle Michelle Maslowski

Birmingham Fellow
Cancer Research UK Career Establishment Award holder

Kendle is a Birmingham Fellow working across the Institutes of Immunology and Immunotherapy (III), and Metabolism and Systems Research (IMSR).

Research in Kendle’s lab is focussed on understanding innate immune pathways in intestinal epithelial cells and their roles in fighting infection and cancer development.

Professor Chris McCabe

Professor Chris McCabe

Professor of Molecular Endocrinology
Theme Lead Endocrinology & IMSR Deputy Director
IMSR and College of MDS Lead for Sustainability

Chris McCabe is Professor of Molecular Endocrinology at the University of Birmingham. He works on mechanisms of endocrine cancers, including thyroid, breast and head and neck tumour models. Specifically, the research of the McCabe group focuses on the action of the sodium iodide symporter NIS in thyroid tumours; assessment of the role of the proto-oncogenes PTTG and PBF in thyroid, breast, and ...

Dr Jonathan W. Mueller

Dr Jonathan W. Mueller

Lecturer in Endocrine Biochemistry
IMSR Deputy Lead for Equality, Diversity & Inclusion

Dr Mueller is interested in enzyme-catalysed reactions that modulate hormone function and act as biological switches. One of these transformations is the dynamic sulfation and de-sulfation of steroid hormones. Dr Mueller’s research group studies these sulfation pathways, using a variety of biochemical, bioanalytical and cell biological techniques.

Jon has authored more than 25 primary ...

Dr Cristina L. Ronchi

Dr Cristina L. Ronchi

Hoffenberg Clinician Scientist in Endocrine Oncology

Cristina Ronchi is an Endocrinologist and clinician scientist with long-standing expertise in endocrine tumors. Her research field mostly focuses on genetic studies and investigations of molecular markers involved in the pathogenesis and prognosis of adrenocortical neoplasia.  She is particularly active in research dissemination and collaborates with several world-leading groups around ...

Professor Alexandra J. Sinclair

Professor Alexandra J. Sinclair

Professor of Neurology

Alex’s group focuses on metabolic neurology: idiopathic intracranial hypertension, headache and cerebrospinal fluid (CSF) disorders. Our translational approach investigates disease pathogenesis and novel therapeutic targets which we then evaluate in our clinical studies.

 

Dr Vicki E. Smith

Dr Vicki E. Smith

Lecturer in Molecular Endocrinology, BBSRC New Investigator Award Holder

Vicki is interested in thyroid biology and the molecular pathogenesis of thyroid disease. Her research focuses on improving existing treatments and identifying novel therapies in thyroid cancer.

Dr Abd A Tahrani

Dr Abd A Tahrani

Senior Lecturer in Metabolic Endocrinology and Obesity Medicine

Abd Tahrani is a Senior Lecturer in Metabolic Endocrinology and Obesity Medicine at the University of Birmingham (UOB), and a Honorary Consultant Endocrinologist and Bariatric Physician and the lead for weight management research and diabetic neuropathy services at the University Hospitals Birmingham NHS Foundation Trust. Dr Tahrani is also the translational research lead at the Centre ...

Dr Jennifer Tamblyn

Dr Jennifer Tamblyn

Clinical Lecturer in Obstetrics and Gynaecology

Jennifer is a Clinical Lecturer in Obstetrics and Gynaecology at Birmingham Women’s & Children’s Hospital. Funded by a Wellbeing of Women Clinical Research Fellowship, Jennifer utilised her PhD to explore vitamin D metabolism in pregnancy, and the potential effects of vitamin D upon immune cell function within the maternal placenta at the University of Birmingham. To help answer ...

Dr Daniel A. Tennant

Dr Daniel A. Tennant

Reader in Metabolic Biochemistry

Dr. Daniel Tennant is a Reader in Metabolic Biochemistry in the Institute of Metabolism and Systems Research (IMSR), situated on the second floor of the Institute of Biomedical Research. He uses stable isotope tracers to investigate changes in the use of nutrients in conditions where oxygen is limiting (hypoxia), or in the presence of genetic mutations that induce a hypoxia-like response. Dan ...

Professor John Terry

Professor John Terry

Interdisciplinary Professorial Fellow
Director, Centre for Systems Modelling & Quantitative Biomedicine
Theme Lead Systems Modelling & IMSR Deputy Director

Professor John Terry is Interdisciplinary Professorial Fellow: a post he holds jointly across Mathematics, Computer Science and the Institute for Metabolism and Systems Research. John’s research transcends traditional discipline boundaries speaking to mathematics, computer science, physics, biology, biomedical and clinical sciences. John has substantially contributed to approaching 70 ...

Professor Shakila Thangaratinam

Professor Shakila Thangaratinam

Professor of Maternal and Perinatal Health
Joint Director of WHO Collaborating Centre for Global Women's Health
Theme Lead Maternal and Reproductive Health & IMSR Deputy Director

Shakila Thangaratinam is a professor of maternal and perinatal health at University of Birmingham. As Consultant Obstetrician she is involved in the care of high-risk mothers at Birmingham Women’s and Children’s NHS Foundation Trust.  

Professor Thangaratinam has established a strong portfolio of research in maternal ...

Professor Javier Zamora

Professor Javier Zamora

Professor of Biostatistics in Maternal and Perinatal Health

Professor Zamora has developed an academic career at the University of Madrid in the Biomathematics department as an Associate Professor of Biostatistics. He has been appointed as Non-Clinical Senior Lecturer of Perinatal statistics in BARC (Barts Research Centre for Women’s Health) in Queen Mary University of London.

Professor Zamora has an outstanding track record of delivering ...