Principal Investigators

Dr Akerman is interested in answering fundamental questions about gene regulation in diseased and healthy pancreatic beta cells through integrated use of molecular, genomic, computational and systems biology. In particular, her aim is to understand how various types of noncoding DNA elements interact to establish gene expression in the pancreatic beta cell.

Member of the 2017/18 Birmingham ...

John Allotey is a lecturer in epidemiology and women’s health at the WHO Collaborating Centre for Global Women's Health within the Institute of Metabolism and Systems Research. He has almost a decade of experience in academic clinical research, primarily in the field of maternal health. His research interests lie in the development, evaluation and implementation of prognostic models ...

Wiebke Arlt is the William Withering Chair of Medicine and Director of the Institute of Metabolism and Systems Research, IMSR, at the University of Birmingham.

She leads a large, multi-disciplinary research group, comprising biologists, biochemists, clinician scientists and computational biologists, investigating the role of steroids in health and disease, with a particular focus on the link ...

Davide Calebiro is a Professor of Molecular Endocrinology and Wellcome Trust Senior Research Fellow at the Institute of Metabolism and Systems Research (IMSR) and Co-Director of the Centre of Membrane Proteins and Receptors (COMPARE) of the Universities of Birmingham and Nottingham

He leads a multidisciplinary research team comprising biologists, chemists, physicists, engineers and computer ...

Professor Coomarasamy is the Director of Tommy’s National Centre for Miscarriage Care and Research. His research interests are in fertility, early pregnancy and global women’s health.

Gaby is an Associate Professor in Cellular Metabolism and a Senior Fellow of the Higher Education Academy.  She has an interest in energy homeostasis, particularly in fuel sensing mechanisms that may play a role in diabetes and obesity.

Adam's primary research focus is clinical trials in early pregnancy care, with a particular focus on miscarriage, infertility and global women’s health. As Associate Professor of Maternal Health Clinical Trials, he collaborates with the Birmingham Clinical Trials Unit to manage a portfolio of national and international clinical trials. He is also a senior consortium member of the Tommy' ...

Dr Rima Dhillon-Smith is a clinical lecturer based at the  Birmingham Women’s and Children’s Hospital NHS Foundation Trust. She combines her academic work with clinical duties as a registrar in Obstetrics and Gynaecology.  Rima’s main research interests lie in reproductive endocrinology, subfertility, paediatric gynaecology and early pregnancy.  She is a key ...

Sarah Dimeloe is a Birmingham Fellow working across the Institutes of Immunology and Immunotherapy (III), and Metabolism and Systems Research (IMSR).

Research in Sarah’s lab is focused on the metabolism of immune cells and how this underpins their role in health and disease.

Dr Dimeloe is a member of the 2017/18 Birmingham Fellows.

 

Andrew Ewer is Emeritus Professor of Neonatal Medicine based at Birmingham Women’s Hospital. 

Andrew has published research papers in scientific journals including Lancet, NEJM and Cochrane library, as well as reviews and an undergraduate problem-based learning book in the field of paediatrics and neonatology. He has received grants from NIHR Health Technology Assessment, NIH ...

Paul leads the Steroid Metabolism in Cancer Research group at the University of Birmingham. He is an established research figure in the endocrinology and cancer fields. With over a decade of experience in both academic and industrial environments, he has extensive research knowledge on a wide-range of areas. He is an author on over 40 scientific peer-reviewed papers, covering endocrinology, ...

Ioannis’ research work focusses on health issues affecting women and families living in resource-constrained settings, particularly targeting on ways to stop mothers dying from excessive bleeding during childbirth.

Every six minutes, a mother dies from losing too much blood while giving birth. The tragedy is that this is almost always preventable.

Oxytocin is the standard medicine for the ...

Caroline’s research is focussed on the trafficking and signalling of membrane proteins, and how their impairments contribute to endocrine and metabolic disease. She is currently establishing her research group investigating metabolic GPCRs and how they integrate hormonal signals to regulate appetite. 

Janesh Gupta is Professor of Obstetrics and Gynaecology working as an Honorary Consultant at Birmingham Women’s and Children’s Hospital.

Janesh has published over 175 research papers in scientific journals, book chapters, reviews and books and over 100 lectures and presentations to learned societies in the fields of fetal medicine, benign gynaecology (including abnormal uterine ...

I am a Versus Arthritis Fellow with extensive experience in steroid metabolism and in vivo models of chronic inflammation. Patients with chronic inflammatory diseases develop systemic complications such as muscle wasting and bone loss, which contribute to disability and reduced life expectancy. My research group is examining the roles of myeloid and mesenchymal steroid metabolism and signalling ...

Martin’s group investigates the role vitamin D  plays in human health beyond its effects on bone. They focus on vitamin D and immune function, and how this influences infectious diseases, pregnancy and autoimmune disease.

Research in Dave’s lab uses a combination of imaging, chemical biology and genetics to understand how subtle differences in the beta cell barcode may predispose to diabetes in rodents and man.

Jan is Associate Professor in Paediatric Endocrinology and Diabetes, based at the IMSR and at the Department of Endocrinology at the Birmingham Children’s Hospital. His research focuses androgen metabolism. He is interested in inborn errors of steroid metabolism, in particular conditions affecting androgen generation. He combines clinical phenotyping and genetic analysis with in vitro ...

Niki Karavitaki is Clinical Associate Professor in Endocrinology and Honorary Consultant Endocrinologist at the Queen Elizabeth Hospital Birmingham where she co-leads the Pituitary Service and Pituitary MDT.

Her research and clinical interests focus on hypothalamo-pituitary disease (particularly sellar and parasellar tumours and hypopituitarism) covering pathogenesis, management and long-term ...

Mark Kilby’s research focusses on materno-fetal health, with areas of interest including steroids and the feto-placental unit, new technologies in prenatal diagnosis, fetal in utero therapy, monochorionic twins, and maternal immunotolerance and fetal immunity.

Jackson’s research is about andrology and its application in the diagnosis and treatment of infertility, with direct impact on care and quality of life of the patients involved and the birth of the next generation. 

Christian’s research is focused on developing novel experimental and analytical approaches to map metabolic pathway activities without assuming a particular metabolism model.

Kendle is a Birmingham Fellow working across the Institutes of Immunology and Immunotherapy (III), and Metabolism and Systems Research (IMSR).

Research in Kendle’s lab is focussed on understanding innate immune pathways in intestinal epithelial cells and their roles in fighting infection and cancer development.

Chris McCabe is Professor of Molecular Endocrinology at the University of Birmingham. He works on mechanisms of endocrine cancers, including thyroid, breast and head and neck tumour models. Specifically, the research of the McCabe group focuses on the action of the sodium iodide symporter NIS in thyroid tumours; assessment of the role of the proto-oncogenes PTTG and PBF in thyroid, breast, and ...

Dr Mueller is interested in enzyme-catalysed reactions that modulate hormone function and act as biological switches. One of these transformations is the dynamic sulfation and de-sulfation of steroid hormones. Dr Mueller’s research group studies these sulfation pathways, using a variety of biochemical, bioanalytical and cell biological techniques.

Jon has authored more than 25 primary ...

Cristina Ronchi is an Endocrinologist and clinician scientist with long-standing expertise in endocrine tumors. Her research field mostly focuses on genetic studies and investigations of molecular markers involved in the pathogenesis and prognosis of adrenocortical neoplasia.  She is particularly active in research dissemination and collaborates with several world-leading groups around ...

 

 

Vicki is interested in thyroid biology and the molecular pathogenesis of thyroid disease. Her research focuses on improving existing treatments and identifying novel therapies in thyroid cancer.

Jennifer is an Honorary Clinical Lecturer at Birmingham Women’s & Children’s Hospital. Funded by a Wellbeing of Women Clinical Research Fellowship, Jennifer utilised her PhD to explore vitamin D metabolism in pregnancy, and the potential effects of vitamin D upon immune cell function within the maternal placenta at the University of Birmingham. To help answer these questions ...

Professor Daniel Tennant is a Professor of Biochemistry in the Institute of Metabolism and Systems Research (IMSR), situated on the second floor of the Institute of Biomedical Research. He uses stable isotope tracers to investigate changes in the use of nutrients in conditions where oxygen is limiting (hypoxia), or in the presence of genetic mutations that induce a hypoxia-like response. Dan ...

Professor John Terry is Interdisciplinary Professorial Fellow: a post he holds jointly across Mathematics, Computer Science and the Institute for Metabolism and Systems Research. John’s research transcends traditional discipline boundaries speaking to mathematics, computer science, physics, biology, biomedical and clinical sciences. John has substantially contributed to approaching 70 ...

Professor Shakila Thangaratinam is Dame Hilda Lloyd Chair of Maternal and Perinatal Health at the University of Birmingham, and leads the Maternal and Reproductive Health Theme (Jan 2020-). She is the co-Director of WHO Collaborating Centre for Global Women’s Health and academic lead for Women’s Health in Birmingham Health Partners. As Consultant Obstetrician she ...

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Professor Zamora has developed an academic career at the University of Madrid in the Biomathematics department as an Associate Professor of Biostatistics. He has been appointed as Non-Clinical Senior Lecturer of Perinatal statistics in BARC (Barts Research Centre for Women’s Health) in Queen Mary University of London.

Professor Zamora has an outstanding track record of delivering ...